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- Larsson, Lars, et al.
(författare)
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Archaeo-faunal aspects of bog finds from Hassleberga, southern Scania, Sweden
- 2002
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Ingår i: Recent studies in the Final Palaeolithic of the European plain. - 0107-2854. - 9788788415124 ; 39, s. 61-74
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Konferensbidrag (refereegranskat)abstract
- In recent years, small bogs at Hassleberga in southwestern Scania have been turned into crayfish ponds after the removal of the organic sediments. Bones and antlers were noticed in the excavated material and have been systematically collected. The finds include reindeer of both sexes and of different ages. Bones of wild horse, elk, arctic hare and arctic fox were also identified. Radiometric dating shows that the bones from these species were accumulated in the small bogs during the period from late Allerod to late Younger Dryas. It is of special interest that modifications interpreted as being caused by humans have been identified on bones from reindeer and horse. In contrast, artefact finds from any Late Palaeolithic settlement appear to be limited. Among the finds there is a piece of worked reindeer antler. A small number of flint artefacts show the characteristics of Late Palaeolithic tools. The finds at Hassleberga might provide evidence for a very special type of kill site used during the winter. When the ice melted in spring, the remains sank down to the bottom of the kettle holes. The location of Hassleberga gives us a hint of the landscape and its use by man during the Late Palaeolithic.
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- Magnell, Ola, et al.
(författare)
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Butchering of wild boar (Sus scrofa) in the Mesolithic
- 2003
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Ingår i: Mesolithic on the Move. Papers presented the Sixth International Conference on the Mesolithic in Europe, Stockholm 2000. - 1842170899 ; , s. 671-679
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Konferensbidrag (refereegranskat)abstract
- The butchering of wild boar during the Mesolithic in South Scandinavia has been studied through the analysis of cut marks on osteological remains from the sites Ageröd I:HC, Ringsjöholm, Tågerup and Bökeberg III in Scania, Sweden. The study reveals relatively high frequencies of cut marks from dismembering and filleting. The distribution of cut marks indicates a uniformity in the dismembering of wild boar, but it also reveals that two different techniques were used in the skinning of the mandible. A low frequency of dismembering marks on the bones from the lower extremities indicates a less intensive utilisation of the wild boar at Ageröd I:HC. The analysis reveals differences in both the frequency of dismembering marks and the number of black burned bones between sites from Scania, Sweden and Zealand, Denmark. The different age structures of the bones from wild boar recovered from the sites in Scania and Zealand indicate a differentiated processing of juvenile and adult wild boar during the Mesolithic in South Scandinavia.
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- Söderberg, Ola, et al.
(författare)
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Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay.
- 2008
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Ingår i: Methods. - : Elsevier BV. - 1046-2023 .- 1095-9130. ; 45:3, s. 227-32
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Tidskriftsartikel (refereegranskat)abstract
- The activity of proteins is typically regulated by secondary modifications and by interactions with other partners, resulting in the formation of protein complexes whose functions depend on the participating proteins. Accordingly, it is of central importance to monitor the presence of interaction complexes as well as their localization, thus providing information about the types of cells where the proteins are located and in what sub-cellular compartment these interactions occur. Several methods for visualizing protein interactions in situ have been developed during the last decade. These methods in most cases involve genetic constructs, and they have been successfully used in assays of living cell maintained in tissue culture, but they cannot easily be implemented in studies of clinical specimens. For such samples, affinity reagents like antibodies can be used to target the interacting proteins. In this review we will describe the in situ proximity ligation assays (in situ PLA), a method that is suitable for visualizing protein interactions in both tissue sections and in vitro cell lines, and we discuss research tasks when this or other method may be selected.
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- Söderberg, Ola, et al.
(författare)
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Direct observation of individual endogenous protein complexes in situ by proximity ligation
- 2006
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Ingår i: Nature Methods. - : Springer Science and Business Media LLC. - 1548-7091 .- 1548-7105. ; 3:12, s. 995-1000
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Tidskriftsartikel (refereegranskat)abstract
- Cellular processes can only be understood as the dynamic interplay of molecules. There is a need for techniques to monitor interactions of endogenous proteins directly in individual cells and tissues to reveal the cellular and molecular architecture and its responses to perturbations. Here we report our adaptation of the recently developed proximity ligation method to examine the subcellular localization of protein-protein interactions at single-molecule resolution. Proximity probes-oligonucleotides attached to antibodies against the two target proteins-guided the formation of circular DNA strands when bound in close proximity. The DNA circles in turn served as templates for localized rolling-circle amplification (RCA), allowing individual interacting pairs of protein molecules to be visualized and counted in human cell lines and clinical specimens. We used this method to show specific regulation of protein-protein interactions between endogenous Myc and Max oncogenic transcription factors in response to interferon-gamma (IFN-gamma) signaling and low-molecular-weight inhibitors.
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