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1.	Berglund, A, et al. (author) Selection of chemotherapy by ex vivo assessment of tumor sensitivity to cytotoxic drugs: results of a clinical trial 2002 In: Medical oncology (Northwood, London, England). - 1357-0560. ; 19, s. 151- Journal article (peer-reviewed)
2.	Csoka, Katalin, et al. (author) In vitro determination of cytotoxic drug response in ovarian carcinoma using the fluorometric microculture cytotoxicity assay (FMCA). 1997 In: Int J Cancer. ; 72, s. 1008- Journal article (peer-reviewed)
3.	Jonsson, Elin, et al. (author) In vivo activity of CHS 828 on hollow-fibre cultures of primary humantumour cells from patients. 2001 In: Cancer Lett. ; 162, s. 193- Journal article (peer-reviewed)
4.	Mahteme, Haile, et al. (author) Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis 2008 In: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 34:5, s. 547-552 Journal article (peer-reviewed)abstract AIMS: To investigate if the pattern of cytotoxic drug sensitivity in vitro in patient samples of peritoneal carcinomatosis (PC) is supportive to the current standardized approach for drug selection for perioperative intraperitoneal chemotherapy (IPC). METHODS: The cytotoxic effect of cisplatin, oxaliplatin, irinotecan, 5-fluorouracil, mitomycin-C, doxorubicin and melphalan was investigated in vitro on tumour cells from 223 patient tumour samples of different PC origins. RESULTS: Considerable differences in cytotoxic drug sensitivity between tumour types of the PC entity and within each tumour type were observed. Cisplatin showed high cross-resistance with oxaliplatin but low cross-resistance with doxorubicin and irinotecan. No cross-resistance was found between irinotecan and doxorubicin. The dose-response relationships for melphalan and irinotecan in individual samples showed great variability. CONCLUSIONS: The activity in vitro of cytotoxic drugs commonly used in IPC for PC is very heterogeneous. Efforts for individualizing drug selection for PC patients undergoing IPC seem justified.

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Type of publication: journal article (4)Undo refine

Type of content: peer-reviewed (4)

Author/Editor: Larsson, Rolf (4); Nygren, Peter (4); Tholander, B (4)Undo refine; de la Torre, M (2); Bergh, J (1); Karlsson, MO (1); show more...; Glimelius, Bengt (1); Påhlman, Lars (1); Glimelius, B (1); Berglund, A. (1); Hagberg, H (1); Oberg, K (1); Kristensen, J (1); von Heideman, Anne (1); ASTROM, G (1); Graf, Wilhelm (1); Mahteme, Haile (1); Grundmark, Birgitta (1); Brodin, O (1); Fjallskog, ML (1); von Heideman, A (1); Paro, G (1); Gerdin, E (1); Csoka, Katalin (1); Friberg, LE (1); Jonsson, Elin (1); Binderup, L (1); Hassan, Saadia B. (1); show less...

University: Uppsala University (4); Karolinska Institutet (2)

Language: English (4)

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