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- Jensen, Eva, et al.
(författare)
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Changes in hemostasis during pediatric heart surgery: impact of a biocompatible heparin-coated perfusion system.
- 2004
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Ingår i: The Annals of thoracic surgery. - : Elsevier BV. - 0003-4975. ; 77:3, s. 962-7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: This study describes the response in hemostasis during open-heart surgery with cardiopulmonary bypass (CPB) in children (<== 10 kg) and tests the hypothesis that the use of a biocompatible perfusion system, in comparison with a conventional system, causes less hemostatic activation. METHODS: Prospective, randomized, controlled clinical study. Forty consecutive children <== 10 kg were included and divided into two groups: group bioc. (n = 19) treated with a fully heparin-coated system, centrifugal pump, and a closed circuit, and group conv. (n = 21) treated with an uncoated system, roller pump, and a hard shell venous reservoir. Concentrations of plasma thrombin-antithrombin (TAT), D-dimer, tissue plasminogen activator antigen (t-PA ag), and the complex consisting of tissue plasminogen activator and its inhibitor plasminogen activator inhibitor-1 (t-PA-PAI-1) were measured. RESULTS: The biochemical variables measured increased significantly in both groups during the study period. There was less activation of fibrinolysis during cardiopulmonary bypass (t-PA ag: p = 0.009) in patients treated with the biocompatible perfusion system than in patients treated with the conventional system. A trend in favor of the biocompatible system based on the D-dimer and TAT data (p = 0.07 for both measurements) was observed but no significant intergroup differences regarding these variables or t-PA-PAI-1 were found. CONCLUSIONS: Open-heart surgery with cardiopulmonary bypass in children (<== 10 kg) causes transient activation of the coagulation and fibrinolytic systems. This study demonstrates that the use of a biocompatible perfusion system results in a lower extent of activation of fibrinolysis during CPB than the use of a conventional system.
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- Larsson, Lars, 1945, et al.
(författare)
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Principi di Yacht Design (in Italian)
- 2022
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Principles of Yacht Design has established itself as the standard book on the subject for practising designers, naval architecture students, discerning boat owners as well as the boatbuilding industry as a whole. The fifth edition is completely revised and expanded. It examines every aspect of the process of yacht and powerboat design. The new edition includes new findings from recent research in aero and hydrodynamics, as well as covering the most recent changes to building standards. The authors have used a newly built 41-foot performance cruiser to demonstrate the practical application of yacht design theory. This new edition includes photos of the building process and detailed explanations.
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- Larsson, Lars, 1945, et al.
(författare)
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Principles of Yacht Design (4th ed.)
- 2013
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- The first edition of the Principles of Yacht Design was published in 1994. Since then there have been two new editions, and the book has been translated into German, Japanese and Korean. A special edition is published in the United States. The book has thus been very well received, and in this fourth edition we have kept the structure and the main contents of the previous editions. The basic idea is to cover all aspects of yacht design, from the specification, through the hydro- and aerodynamic design, structural assessment and layout, to the final evaluation. Emphasis is placed on concept descriptions, but formulae, separated from the text, are included in sufficient depth for a complete design of a new yacht. An important feature of the book is the example yacht, used throughout the book to exemplify the use of the formulae. This is where the present edition differs most from the previous ones. A completely new modern performance cruiser, the YD–41 has replaced the original YD-40, designed for the first edition. This has called for a revision of most of the figures and important parts of the text. In connection with the new design, the statistics found in the design chapters have been completely revised, and are now based on yachts designed during the past ten years. The primary designer of the new yacht is Michal Orych, who is now welcomed as the third author of the book.Since the first edition there have been regular updates particularly in two areas: hydrodynamic formulas based on the Delft systematic yacht hull series (DSYHS), and ISO standards for the safety and structural integrity of sailing yachts. The authors are indebted to Dr Lex Keuning, the manager of DSHYS, for his advice in this matter. The ISO 12217-2 seaworthiness standard was developed under the chairmanship of Andrew Blyth, and the ISO scantlings standard 12215 under the late Fritz Hartz and more recently Gregoire Dolto. Thanks are due to all of them for their support, and for their permission to use unpublished parts of the standards. In the present edition, new resistance formulae are presented from DSHYS, and the ISO 12215 standard has been updated with respect to rudders and appendages.Since the first edition there has been a dramatic development in Computational Fluid Dynamics (CFD), and this is reflected in the present edition, where a considerably expanded section in the last chapter is devoted to this exciting technique.
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