| 1. |
- Wysocki, Maciej, 1969, et al.
(författare)
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Anisotropic and tension-compression asymmetric model for composites consolidation
- 2010
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Ingår i: Composites. Part A, Applied science and manufacturing. - : Elsevier BV. - 1359-835X .- 1878-5840. ; 41:2, s. 284-294
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Tidskriftsartikel (refereegranskat)abstract
- A constitutive model for anisotropic and tension-compression asymmetric response of a fibrous preform is developed and solved using a FE software. Applicability of the method to complex geometries is demonstrated by analysis the consolidation of an axisymmetric filament wound pressure vessel made from commingled yarns. Three different winding patterns are considered. In conclusions, the consolidation of the whole vessel, except at the opening, is prevented by the loading mode, where the pressure is applied on the interior. To succeed in manufacturing of this type of pressure vessel, use of an oversized preform that allows extension in the fibre direction is suggested.
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| 2. |
- Wysocki, Maciej, et al.
(författare)
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Modelling the consolidation of partially impregnated prepregs
- 2009
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Ingår i: 17th International Conference on Composite Materials, ICCM-17; Edinburgh; United Kingdom; 27 July 2009 through 31 July 2009.
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Konferensbidrag (refereegranskat)abstract
- A finite element model is developed to solve consolidation problems for composites manufacturing. The model is developed from a generic two-phase continuum theory allowing for coupling between the solid and fluid responses. The code is applied to a case study consisting of consolidation of a hat stringer to evaluate nonlinear effects.
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| 3. |
- Larsson, Mikael, et al.
(författare)
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Comprehensive study regarding greenhouse gas emission from iron ore based production at the integrated steel plant SSAB Tunnplåt AB
- 2006
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Ingår i: International Journal of Green Energy. - : Informa UK Limited. - 1543-5075 .- 1543-5083. ; 3:2, s. 171-183
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Tidskriftsartikel (refereegranskat)abstract
- During the years 2001-2002, a comprehensive study regarding CO2 emissions related to the steel production for the integrated steel making production route, was carried out. The study was financed by SSAB and carried out by a research group with members from SSAB, MEFOS and LTV. The aim was to study the emissions from the existing system and how these could be influenced by process changes and by process modifications. The calculations were made using a global spreadsheet model for calculating the CO2 emissions, developed from an existing energy and process integration model of the same system. The calculated cases included the existing BF/BOF route as well as integration of other processes, e.g., an electric arc furnace, DR processes, COREX and a new future smelting reduction process concept (Sidcomet). All new existing alternative ore based process technologies would increase the specific CO2 emission from the system. A technology transfer to scrap based metallurgy would significantly decrease the emission level, but is not feasible for SSAB, due to the future product mix and the structure of scrap availability. In a 5-20 year perspective, the existing steel making process route with the use of magnetite ore for pellet production has the lowest specific CO2 emission. In a long-term perspective, 20-50 years, alternative process routes, e.g., based on H2 and DRI, could be of interest. Studies on such changes are, however, big projects and should be carried out as joint European and/or international efforts
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| 4. |
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| 5. |
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| 6. |
- Govender, Rydvikha, 1989, et al.
(författare)
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Therapy for the individual: Towards patient integration into the manufacturing and provision of pharmaceuticals
- 2020
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Ingår i: European Journal of Pharmaceutics and Biopharmaceutics. - : Elsevier BV. - 1873-3441 .- 0939-6411. ; 149, s. 58-76
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Forskningsöversikt (refereegranskat)abstract
- Individualized therapy with pharmaceutical products aims to elicit predictable and optimized treatment responses from specific patients. Doing so requires production platforms and technology capable of tailoring products to individual patient needs. However, despite recent manufacturing innovations and key technologies on the rise, e.g. continuous manufacturing and additive manufacturing (3D printing), the prevailing production paradigm employed in the pharmaceutical industry is mass production. Although mass production is efficient and cost-effective, it is typically based on a ‘one-size-fits-all’ product concept and lacks the flexibility and agility required to fully meet the needs of the individual patient. Indeed, we present data that confirm a suspected major imbalance between the recent medical evolution underpinning personalized/precision medicine and the recent advances in the associated manufacturing technologies. In this context we target the needs of the individual as a main driver for pharmaceutical products which support individualized therapy. We particularly address that a wider integration of critical patient dimensions into the manufacture and provision of pharmaceutical products is pivotal for enabling a patient-centric and efficient mass customization-based production paradigm. Here, we present a critical review of the area and its inherent challenges which aims to clarify key design requirements for establishing mass customization opportunities. Through primary sources of scientific information for individualized therapies, patient needs are captured, analysed, and conceptualized. This summarized set of key drivers provides the basis for a proposed patient-centric framework of requirements for use in design of product and production platforms for mass customization. The extent to which emerging pharmaceutical manufacturing technologies satisfy key individual patient needs is explored through a high-level assessment against the proposed patient-centric framework, with special attention paid to oral dosage forms. Altogether this holistic review and position paper, with its constituent steps, reveals major gaps in the evolution of Product-Process-Production approaches and solutions required for producing affordable individualized/personalized pharmaceuticals that respond to the needs and demands of the individual patient. Lastly, in a brief commentary and outlook, we suggest key research directions for closing gaps and addressing manufacturing technology challenges. We also articulate the importance of tackling them in a holistic, integrated way, together with challenges in product individualization and personalization.
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| 7. |
- Andersson, Niklas, et al.
(författare)
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Calibration of a polyethylene plant for grade change optimisations
- 2011
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Ingår i: 21ST European Symposium on Computer Aided Process Engineering. - 1570-7946. - 9780444538956 ; 29, s. 673-677
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Konferensbidrag (refereegranskat)abstract
- A polyethylene plant model coded in Modelica and based on a nonlinear MPC model currently used at Borealis AB is considered for calibration. A case study of model calibration at steady-state for four different operating points are analysed, both when looking at one operating point separately, but also to calibrate several simultaneously. Both model parameters and reactor inputs are calibrated for true plant measurement data. To solve the parameter estimation problem, the JModelica.org platform is used, offering tools to express and solve calibration problems. Calibration was obtained with narrow confidence intervals and shows a potential to improve the model accuracy by changing the parameter values. The results will be used for dynamic optimisations of grade changes.
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| 8. |
- Hård af Segerstad, Per, 1977, et al.
(författare)
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Micro-mechanical model of a viscoplastic open-cell foam
- 2005
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Ingår i: Computational Plasticity VIII - Fundamentals and applications, D.R.J. Owen, E. Onate, and B. Suarez, CIMNE, Barcelona. ; , s. 755-758
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Konferensbidrag (refereegranskat)
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| 9. |
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| 10. |
- Larsson, Per-Ola, et al.
(författare)
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Modelica Based Grade Change Optimization for a Polyethylene Reactor
- 2010
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Konferensbidrag (refereegranskat)abstract
- This paper presents a dynamic optimization procedure of grade changes of polyethylene production. The optimization is built upon a novel modular Modelica library containing e.g., non-linear DAE models for polyethylene reactors based on models currently used in nonlinear MPC of industrial reactors at Borealis AB. Using Optimica, which extends the Modelica language with constructs for optimization problems, and JModelica.org, a novel framework to translate such optimization problems into NLP problems, grade transition ptimization problems can be solved. The solution procedure and a transition xample with optimal inputs and outputs are given in the paper showing promising results.
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