| 1. |
- Akre [Fall], Katja, 1971-, et al.
(författare)
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Risk for gastric cancer after antibiotic prophylaxis in patients undergoing hip replacement
- 2000
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Ingår i: Cancer Research. - Birmingham, USA : American Asoociation for Cancer Research. - 0008-5472 .- 1538-7445. ; 60, s. 6376-
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Tidskriftsartikel (refereegranskat)abstract
- Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationwide case-control study nested in a cohort of 39,154 patients who underwent hip replacement surgery between 1965 and 1983. Such patients frequently receive prophylactic antibiotic treatment. During follow-up through 1989, we identified 189 incident cases of gastric cancer. For each case, three controls were selected from the cohort. Exposure data were abstracted from hospital records. Blood samples from a separate cohort undergoing hip replacement surgery were analyzed for anti-H. pylori IgG before and after surgery. Both long-term antibiotic treatment before surgery [odds ratio (OR), 0.3; 95% confidence interval (CI), 0.1-0.7] and prophylactic antibiotic treatment (OR, 0.7; 95% CI, 0.5-1.1) conferred a reduction in gastric cancer risk. The reduction appeared stronger after 5 years (OR, 0.6; 95% CI, 0.3-1.2) than during shorter follow-up after hip replacement (OR, 0.8; 95% CI, 0.4-1.7). There was an apparent decrease in risk with increasing body weight-adjusted doses of antibiotics (P = 0.13). However, the rate of H. pylori antibody disappearance was not strikingly higher in the cohort of patients undergoing hip replacement than in a control cohort. Our findings provide indirect support for the hypothesis that treatment with antibiotics at a relatively advanced age reduces the risk of gastric cancer.
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| 2. |
- Borg, Tomas, 1963-, et al.
(författare)
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Development of a pelvic discomfort index to evaluate outcome following fixation for pelvic ring injury
- 2015
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Ingår i: Journal of Orthopaedic Surgery. - : Sage Publications. - 1022-5536 .- 2309-4990. ; 23:2, s. 146-149
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To develop a pelvic discomfort index (PDI) to evaluate outcome following fixation for pelvic ring injury.METHODS: 29 female and 44 male consecutive patients (mean age, 36 years) underwent internal fixation for pelvic ring injury of type B1 (n=10), B2 (n=22), B3 (n=15), C1 (n=18), C2 (n=5), and C3 (n=3), based on the AO/OTA classification. At postoperative 6, 12, and 24 months, patients were asked to assess their discomfort in the pelvis using a 14-item questionnaire. Three questions were open-ended, and responses were categorised by a single assessor. The remaining 11 questions were closed-ended and had 6 ordinal options from 'no discomfort' (score=0) to 'extremely severe discomfort' (score=5). The content validity and relevance of the 11 closed-ended questions was determined. The 14-item questionnaire was compared with the 36-item Short Form Health Survey (SF-36).RESULTS: Respectively at postoperative 6, 12, and 24 months, 78%, 71%, and 71% of the patients completed the 14-item questionnaire. Based on the factor analysis and responses to the open-ended questions, the number of items was reduced to 6 including pain, walking, mobility of the hips, loss of sensation in the legs, sexual life, and operation scar. Four factors could explain 96% of the total variance. The first factor involved the first 3 items (pain, walking, and hip motion) and addressed 'pelvis', whereas 3 factors involved the remaining items and each addressed peripheral neurology, sexual life, and operation scar. A PDI was developed using these 6 items. The PDI had high internal reliability (α=0.89), adequate content and criterion validity, and moderate correlation with the SF-36 total score or scores of physical function, bodily pain, and general health (r=0.50-0.77).CONCLUSION: The PDI provides valid, specific, and relevant information to assess outcome following fixation for pelvic ring injury.
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| 3. |
- Borg, Tomas, 1963-, et al.
(författare)
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Health-related quality of life and life satisfaction in patients following surgically treated pelvic ring fractures. A prospective observational study with two years follow-up
- 2010
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Ingår i: Injury. - : Elsevier. - 0020-1383 .- 1879-0267. ; 41:4, s. 400-404
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Pelvic ring fractures caused by high-energy trauma are severe injuries with well described radiological and clinical outcomes, whereas description from the patient's perspective is less well documented. The purpose of this study was to investigate patient-reported outcome following surgical treatment of pelvic fractures using quality of life instruments.METHODS: All 54 patients (28 male/26 female, ages 16-68) with pelvic fractures referred to our institution for surgical treatment 2003-2005 were prospectively included. The most common trauma was motor vehicle accident (44%). Additional injuries were seen in 74% and in 31% the ISS was >or=16. There were 31 B and 23 C type fractures. Patients were followed for two years using two validated questionnaires, SF-36 and LiSat-11, the latter an instrument consisting of 11 questions for evaluation of satisfaction with different aspects of life.RESULTS: 45 patients could be followed according to the study protocol for two years while 2 were untraceable and 1 died from unrelated causes. Of 6 nonresponders, 5 were unable due to psychiatric disorder. At two years pelvic fracture patients scored lower than the reference population in both physical and mental domains (SF-36). Highest mean score, 68, was in the domain Social Function (norm 89) while lowest mean score, 38, was in the domain Role Physical (norm 86). The mean score closest to the normative was for general health with 61 for patients and 78 for the normative group. In LiSat-11 pelvic fracture patients scored lower than the reference population in all areas. Satisfaction with life as a whole was 31% compared with 60% in the normative group.CONCLUSIONS: Two years after surgical treatment of pelvic ring fractures, patients reported substantially lower quality of life for both physical and mental domains, when compared with a reference population, even when radiological and clinical outcomes were considered favourable.
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| 4. |
- Borg, Tomas, et al.
(författare)
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Quality of Life After Operative Fixation of Displaced Acetabular Fractures
- 2012
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Ingår i: Journal of Orthopaedic Trauma. - : Lippincott Williams & Wilkins. - 0890-5339 .- 1531-2291. ; 26:8, s. 445-450
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this study was to determine quality of life (QoL) changes over time after internal fixation of acetabular fractures.Design: This pertains to a prospective cohort study, which was single centered.Setting: The study was conducted at the University Hospital.Patients: One hundred thirty-six patients (108 men, 28 women), age 17-83 years operated for an acetabular fracture during 2004-2008 were prospectively included and followed up for 2 years.Main Outcome Measures: QoL was evaluated via Short Form-36 (SF-36) and Life Satisfaction-11 at 6, 12, and 24 months. Radiographs were evaluated according to Matta at 2 years.Results: The most frequent fracture types were posterior wall (n31), associated anterior-posterior hemitransverse (n34), and associated both column (n29). One hundred twenty-nine patients could be assessed at 2 years, 4 did not respond, and 3 had died. The patients scored lower than norms in all 8 SF-36 domains with improvement over time for Physical Function (P < 0.0001) and Role Physical (P < 0.0001). The patients with postop reduction 0-1 mm scored better (P < 0.001-0.039) in 7 domains, all except vitality (P = 0.07), when compared with patients with residual displacement of >= 2 mm. Life satisfaction did not change with time and showed lower scores than normative in 9 of 11 items. Nineteen patients had undergone total hip replacement, and the strongest predictor was acetabular or femoral head impaction.Conclusions: QoL in surgically treated patients with displaced acetabular fracture keeps improving in physical SF-36 domains over a 2-year period although still lower than norms, and anatomical reduction results in better QoL outcome in most dimensions.
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| 5. |
- Borg, Tomas, et al.
(författare)
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Quality of life in patients operated for pelvic fractures caused by suicide attempt by jumping
- 2010
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Ingår i: Scandinavian Journal of Surgery. - : Sage Publications. - 1457-4969 .- 1799-7267. ; 99:3, s. 180-186
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Tidskriftsartikel (refereegranskat)abstract
- Background and Aims: Jumping from great height is an aggressive method of suicide attempt where the frequent combination of psychiatric disorder and somatic injuries makes treatment difficult. Our aim was to evaluate survival rate and get patient-reported outcome in patients operated for a pelvic or acetabular fracture sustained when jumping from a height as a suicide attempt. Patients and Methods: During the period 2003-2004, 12 patients (11 women) of whom eight were below 30 years of age, were prospectively included. At two years HRQoL (Health-Related Quality of Life) questionnaires (SF-36 and LiSat-11) were used to describe outcome, and at four years a structured psychiatric interview SCID-I (Structured Clinical Interview for DSM-IV Axis I Disorders) was done. Results: At four years all patients were alive. One patient had made a new suicide attempt. Eight patients gave adequate reply on SF-36 and LiSat-11 at two years. In all domains patients scored lower than a norm group with the relatively lowest values in physical domains. Younger patients assessed life as better when compared with middle aged patients. Conclusions: This study showed a very low recurrence rate into suicidal behaviour in a group of jumpers and all patients were alive at four years after a suicidal attempt by jumping. The high proportion of psychiatric disorder in these patients highlights the need for a combined treatment effort between orthopaedic and psychiatric expertise.
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| 6. |
- Borg, Tomas, et al.
(författare)
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Questionnaire to assess treatment outcomes of acetabular fractures
- 2012
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Ingår i: Journal of Orthopaedic Surgery. - : SAGE Publications. - 1022-5536 .- 2309-4990. ; 20:1, s. 55-60
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSETo construct a questionnaire to assess outcomes in patients who underwent internal fixation for acetabular fractures.METHODS27 female and 100 male consecutive patients (mean age, 50 years) who underwent internal fixation for acetabular fractures were included. Patients were asked to report their outcomes at months 6, 12, and 24 using a questionnaire. The initial questionnaire was constructed by an expert group. There were 11 closed questions, each came with 6 responses from ?no discomfort? to ?very severe discomfort?. Three open questions were added to cover topics that were not included. The content validity and relevance of the 11 closed questions was determined using factor analysis to determine the number of factors involved. Factorability of the correlation matrix was measured via the Bartlett test of sphericity and Kaiser-Meyer- Olkin (KMO) measure of sampling sufficiency. Factor loadings of <0.50 were considered acceptable for factor representation. Reliability in terms of internal consistency was expressed as Cronbach alpha coefficients. The responses to the 3 open questions were analysed and categorised by a single assessor.RESULTS120 (94%) of the patients completed at least one questionnaire, and 92 (72%) completed all 3 questionnaires during the follow-up period. Based on responses to the 6-month questionnaire, responses to the 11 closed questions were significantly intercorrelated (Spearman 0.17-0.80). After factor analysis and analysis of responses to open questions, the number of questions was reduced to 6 and included questions related to pain, walking, hip motion, leg numbness, sexual life, and operation scar. Reliability of the questionnaire was estimated to alpha=0.89. Criterion validity was adequate with a high correlation with the Short Form 36 (r=0.56-0.80).CONCLUSIONPatients treated with acetabular fractures can be adequately assessed using the 6-item questionnaire and one global question concerning impact on activities of daily living.
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| 7. |
- Hernefalk, Björn, et al.
(författare)
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Estimating pre-traumatic quality of life in patients with surgically treated acetabular fractures and pelvic ring injuries : Does timing matter?
- 2016
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Ingår i: Injury. - : Elsevier. - 0020-1383 .- 1879-0267. ; 47:2, s. 389-394
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: Evaluation of patient-assessed functional outcome in traumatic conditions has specific challenges. To obtain pre-traumatic data to allow for comparison during follow-up, retrospective assessments are needed. How such data is affected by posttraumatic time-point chosen for evaluation is unknown. The primary purpose of this study was to investigate how the time-point chosen for retrospective assessment of pre-traumatic quality of life (QoL) in patients with surgically treated acetabular fractures and pelvic ring injuries influenced the results. A secondary purpose was to examine the pre-traumatic QoL-profile in patients with these injuries.PATIENTS AND METHODS: 73 patients were included, where 50 had an acetabular fracture and 23 a pelvic ring injury. Pre-traumatic QoL was evaluated using the generic instruments SF-36 and EQ5D in conjunction with the condition-specific Pelvic Trauma Questionnaire (PTQ). Questionnaires were completed at three time points: 0, 1 and 2 months post-surgery.RESULTS: Number of responders were 73 patients at 0 months, 61 patients at 1 month and 53 patients at 2 months. 50 patients answered the questionnaires at all three time-points. A trend was observed with all instruments where patients estimated a better pre-traumatic status with narrower distributions when assessment was delayed. At 2 months, scores for 4 out of 8 SF-36 domains where significantly higher compared to 0 months. For EQ5D, EQ VAS improved at 1 and 2 months compared to month 0 results but no other significant differences between time-points were found. Results from the PTQ demonstrated no significant differences over time. Pre-traumatic quality of life was high and for SF-36 comparable to a population norm. A very low level of pre-existing discomfort from the pelvic region was reported through the PTQ.CONCLUSION: Patients with surgically treated acetabular fractures and pelvic ring injuries estimate a higher pre-traumatic functional status when assessment is carried out at 1 or 2 months post-surgery compared to perioperative measurements. The SF-36 seems to be more sensitive than the EQ5D in this respect. Pre-traumatic QoL in patients with surgically treated acetabular fractures and pelvic ring injuries is generally high and pre-existing discomfort from the pelvic region is uncommon.
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| 8. |
- Hernefalk, Björn, et al.
(författare)
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Patient-reported Outcome in Surgically Treated Pelvic Ring Injuries at 5 Years Post-surgery
- 2021
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Ingår i: Scandinavian Journal of Surgery. - : Sage Publications. - 1457-4969 .- 1799-7267. ; 110:1, s. 86-92
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: Long-term prospective data on patient-reported outcome after surgical treatment of pelvic ring injuries are scarce. This study aimed at describing results at 5 years post-surgery using validated outcome measures.PATIENTS AND METHODS: Patients admitted for surgical treatment of pelvic ring injuries were prospectively included and asked to report their outcome at 1, 2 and 5 years post-surgery using two patient-reported outcome measures: the generic Short-Form 36 and the condition-specific pelvic discomfort index. Data were evaluated using mixed-effects linear models.RESULTS: There were 108 patients (68 males and 40 females), mean age 38 years. Injury type according to the AO/OTA-classification was B-type in 68 patients and C-type in 40 patients. No domain of the Short-Form 36 reached norm values at 5 years post-surgery. Females reported a worse outcome than males concerning general health (p < 0.01) at 5 years. Recovery of physical function (p < 0.01), mental health (p = 0.04), and pain (p = 0.01) was observed for males at 5 years compared to earlier assessments, while females on the contrary described more pain at this time-point (p = 0.03). Mean pelvic discomfort index at 5 years was 27, indicating moderate residual pelvic discomfort overall. Males reported less pelvic discomfort than females at 5 years (p = 0.02) and improved when compared to results at 2 years (p = 0.02), while females did not. Influence of age, fracture type, and presence of associated injuries on patient-reported outcome was limited.CONCLUSION: Surgically treated pelvic ring injuries are associated with long-standing negative effects on patient-reported outcome. Males report a better outcome than females at 5 years post-surgery.
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| 9. |
- Larsson, Sune, et al.
(författare)
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Augmentation of Tibial Plateau Fractures with Calcium Phosphate Cement : A Randomized Study Using Radiostereometry
- 2004
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Konferensbidrag (refereegranskat)abstract
- Purpose: One problem with tibial plateau fractures that involve a depressed articular fragment is the difficulty of maintaining reduction until healing. The conventional method is to fill the subchondral void with autologous bone transplant followed by restricted weightbearing for 8 to 12 weeks. Recently, biomaterials have been introduced that might overcome several problems associated with bone transplant. The purpose of this study was to evaluate an injectible calcium-phosphate cement when used as a bone graft substitute in lateral tibial plateau fractures, with special emphasis on the stability of the elevated articular fragment.Methods: Twenty-four patients with a lateral tibial plateau fracture type 41-B2 or 41-B3 (OTA classification) were included. The authors operated on all patients. Conventional metal fixation was used to fix the fracture following elevation of the articular fragment. The subchondral void was filled with injectable calcium-phosphate cement (Norian SRS, Synthes) or conventional iliac bone graft according to randomization during surgery. There were 12 patients in each group with an average age of 50 and 52 years, respectively. During surgery, tantalum markers were inserted for subsequent radio stereometry (RSA) (RSA Biomedical Innovation, Umeå, Sweden), a radiologic technique that enables measurement of movement along and around three orthogonal axes with a precision of less than 0.5 mm and 0.7°. Continuous passive motion was begun immediately after surgery. Weightbearing was restricted to 20 kg for 6 weeks in the SRS group and for 12 weeks in the control group. Radio stereometry was performed before weightbearing and at 1, 6, and 12 weeks and at 6 and 12 months. Conventional radiographs were used for assessment of reduction and healing. Clinical evaluation (Lysholm score and a visual analog scale score of 0 to 10 for pain) was conducted by a physiotherapist. For assessment of compliance with regard to weightbearing, patients were examined with F Scan (Tecscan, Inc., Boston, Massachusetts, USA) at each time point.Results: No patients were lost but two were excluded from the RSA evaluation due to technical problems. All fractures healed. There was one deep infection (SRS). At 6 weeks, average weightbearing was 22 kg in the SRS group and 19 kg among the controls (NS); at 12 weeks, 66 kg vs. 28 kg (P <0.001); and at 6 and 12 months, on average, between 66 and 72 kg with no difference between groups. Pain during activity was lower in the SRS group at 1 week (P <0.01), 6 weeks (P <0.004), 3 months (P <0.005), and at 6 months (P <0.02), with no difference at 1 year. The Lysholm knee score was better at 6 weeks (P <0.01), 12 weeks (P <0.002), and 6 months (P <0.02) in the SRS group, and there was no significant difference at 1 year. Radio stereometry revealed movement of the articular fragment in all patients. The total translation was, on average, 1.41 mm in the SRS group and 3.88 mm in the controls (P <0.001). In both groups the most significant movement occurred during the first 6 weeks, and there was no significant movement of the articular fragment from 6 to 12 months, indicating stable healing. The most typical pattern of movement was subsidence along the vertical axis or rotation in the transversal axis (forward tilt) or both, and as toe-out rotation around the vertical axis. One patient from the SRS group had a migration exceeding 3 mm, and two controls had a migration exceeding 5 mm.Conclusion/Significance: Injectable calcium-phosphate cement provided a more stable fixation of the elevated articular fragment in lateral tibial plateau fractures when compared with conventional bone graft, despite the fact that cement-augmented patients were allowed earlier weightbearing. Patients treated with cement also had less pain during the entire course of healing when compared with controls. Bone graft substitutes can offer new perspectives for treatment of fractures involving metaphyseal defects, without the side effects associated with bone grafting.
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| 10. |
- Yang, Yishen, 1984-
(författare)
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On Rank-invariant Methods for Ordinal Data
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Data from rating scale assessments have rank-invariant properties only, which means that the data represent an ordering, but lack of standardized magnitude, inter-categorical distances, and linearity. Even though the judgments often are coded by natural numbers they are not really metric. The aim of this thesis is to further develop the nonparametric rank-based Svensson methods for paired ordinal data that are based on the rank-invariant properties only.The thesis consists of five papers. In Paper I the asymptotic properties of the measure of systematic disagreement in paired ordinal data, the Relative Position (RP), and the difference in RP between groups were studied. Based on the findings of asymptotic normality, two tests for analyses of change within group and between groups were proposed. In Paper II the asymptotic properties of rank-based measures, e.g. the Svensson’s measures of systematic disagreement and of additional individual variability were discussed, and a numerical method for approximation was suggested. In Paper III the asymptotic properties of the measures for paired ordinal data, discussed in Paper II, were verified by simulations. Furthermore, the Spearman rank-order correlation coefficient (rs) and the Svensson’s augmented rank-order agreement coefficient (ra) were compared. By demonstrating how they differ and why they differ, it is emphasized that they measure different things. In Paper IV the proposed test in Paper I for comparing two groups of systematic changes in paired ordinal data was compared with other nonparametric tests for group changes, both regarding different approaches of categorising changes. The simulation reveals that the proposed test works better for small and unbalanced samples. Paper V demonstrates that rank invariant approaches can also be used in analysis of ordinal data from multi-item scales, which is an appealing and appropriate alternative to calculating sum scores.
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