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- García-Avilés, Jose Alberto, et al.
(författare)
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Gamification and Newsgames as Narrative Innovations in Journalism
- 2022
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Ingår i: Total Journalism. - Cham : Springer. - 9783030880279 - 9783030880286 ; , s. 53-67
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Bokkapitel (refereegranskat)abstract
- This chapter explores how innovative narratives, supported by a combination of playful approaches and technological convergence, provide a reconfiguration of digital news storytelling. Newsgames integrate two opposing logics: the culture of journalism, based on truthfulness and credibility, and the culture of games, characterized by the creation of imaginary worlds, persuasion and mechanics. We analyse The Ocean Game (2019) and The Amazon Race (2019), which use different procedural strategies. We examine the development of gamification in journalistic storytelling, which uses game elements to enhance the user experience. The relationship that gamified news products establish with the audience illuminates changes in the rhetorical and structural dynamics between the news organization, the media workers, and the users. Thus, innovation in journalistic narrative through gamification and newsgames might translate into effective ways of producing content that combines rigour in substance with attractiveness in form, while preserving journalistic quality and incorporating the playful elements of games.
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- Saving, Jenny
(författare)
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Treatment of distal radius fractures : clinical outcome, regional variation and health economics
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A distal radius fracture (DRF) remains the most common fracture encountered in health care. DRFs have traditionally been treated with a plaster or surgically with percutaneous methods. Since the end of the 20th century, when internal fixation with a volar locking plate (VLP) was introduced, the incidence of DRF surgery in general and of plating in particular have increased markedly. The change in practice took place despite the lack of evidence of the superiority of VLPs over percutaneous methods for adult patients and over non-operative treatment for elderly patients. The aim of this thesis was to compare clinical outcome between treatment methods and to describe regional variation in surgical treatment of DRFs in Sweden. Study I was a descriptive study using registry data from 22 378 individuals in the Swedish national patient registry from 2010 to 2013. There was a large variation in surgical treatment regimens for DRFs among the 21 health care regions, not explained by age or gender. Proportions of internal fixation varied from 41% to 95%, pin fixation varied from 2% to 44% and external fixation (EF) varied from 1% to 19%. Study II and IV constituted a three-year follow-up of 118 and 113 patients respectively, 50-74 years old with an unstable dorsally displaced DRF, from a previously published randomized controlled trial of 140 patients, allocated to VLP or EF. Patient-reported outcome measures (PROMs) as well as grip-strength, range of motion, occurrence of osteoarthritis and complication rates presented in Study II, were similar in both groups. The VLP group displayed a higher mean total cost and less gained quality of life adjusted life-years (QALYs) compared with the EF group, indicating in Study IV that VLP is not cost-effective in comparison to EF. Study III was a randomized controlled trial, allocating 140 patients, 70 years or older, with an unstable dorsally displaced DRF to VLP or non-operative treatment. At 12 months 119 patients were evaluated and PROMs, grip-strength, volar flexion and radiographs were significantly better for the VLP group. Complication rates were similar. In conclusion, surgical treatment regimens for DRFs vary widely among health care regions in Sweden and when comparing treatment outcomes; for elderly patients VLP fixation seems to yield superior clinical results compared with non-operative treatment, but for patients aged 50-74 years, VLP fixation does not seem to yield superior clinical results and does not seem to be cost-effective as compared with EF in a three-year perspective.
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- Zetterström, Henrik
(författare)
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Dokumentation
- 2005. - 2
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Ingår i: Anestesi. - : Liber. ; , s. 330-340
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Boixeda, P, et al.
(författare)
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Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies. : Perspectivas de futuro en láseres, nuevas tecnologías y nanotecnología en dermatología.
- 2015
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Ingår i: Actas dermo-sifiliograficas. - : Elsevier BV. - 1578-2190 .- 0001-7310. ; 106:3
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Tidskriftsartikel (refereegranskat)abstract
- We review novel technologies with diagnostic and therapeutic applications in dermatology. Among the diagnostic techniques that promise to become part of dermatologic practice in the future are optical coherence tomography, multiphoton laser scanning microscopy, Raman spectroscopy, thermography, and 7-T magnetic resonance imaging. Advances in therapy include novel light-based treatments, such as those applying lasers to new targets and in new wavelengths. Devices for home therapy are also appearing. We comment on the therapeutic uses of plasma, ultrasound, radiofrequency energy, total reflection amplification of spontaneous emission of radiation, light stimulation, and transepidermal drug delivery. Finally, we mention some basic developments in nanotechnology with prospects for future application in dermatology.
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- Michaels, Thomas C.T., et al.
(författare)
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Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
- 2020
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Ingår i: Nature Chemistry. - : Springer Science and Business Media LLC. - 1755-4330 .- 1755-4349. ; 12:5, s. 445-451
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Tidskriftsartikel (refereegranskat)abstract
- Oligomeric species populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental molecular pathways that control their dynamics have yet to be elucidated. By developing a general approach that combines theory, experiment and simulation, we reveal, in molecular detail, the mechanisms of Aβ42 oligomer dynamics during amyloid fibril formation. Even though all mature amyloid fibrils must originate as oligomers, we found that most Aβ42 oligomers dissociate into their monomeric precursors without forming new fibrils. Only a minority of oligomers converts into fibrillar structures. Moreover, the heterogeneous ensemble of oligomeric species interconverts on timescales comparable to those of aggregation. Our results identify fundamentally new steps that could be targeted by therapeutic interventions designed to combat protein misfolding diseases. [Figure not available: see fulltext.].
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