SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lawrence C) "

Sökning: WFRF:(Lawrence C)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Tidskriftsartikel (refereegranskat)
  •  
2.
  • Forskningsöversikt (refereegranskat)
  •  
3.
  • Campbell, PJ, et al. (författare)
  • Pan-cancer analysis of whole genomes
  • 2020
  • Ingår i: Nature. - : Nature Publishing Group. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
  • Tidskriftsartikel (refereegranskat)
  •  
4.
  •  
5.
  • Tidskriftsartikel (refereegranskat)
  •  
6.
  • Tidskriftsartikel (refereegranskat)
  •  
7.
  • Graff, M., et al. (författare)
  • Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
  • 2017
  • Ingår i: PLoS Genet. - : Public library service. - 1553-7404 .- 1553-7390. ; 13:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
  •  
8.
  • Weinstein, J. N., et al. (författare)
  • The cancer genome atlas pan-cancer analysis project
  • 2013
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
  • Tidskriftsartikel (refereegranskat)abstract
    • The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.
  •  
9.
  • Hudson, Lawrence N., et al. (författare)
  • The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
  • 2017
  • Ingår i: Ecology and Evolution. - : Wiley-Blackwell. - 2045-7758 .- 2045-7758. ; 7:1, s. 145-188
  • Tidskriftsartikel (refereegranskat)abstract
    • The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
  •  
10.
  • Speliotes, Elizabeth K., et al. (författare)
  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
  • 2010
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1546-1718 .- 1061-4036. ; 42:11, s. 53-937
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (264)
konferensbidrag (11)
forskningsöversikt (11)
bokkapitel (5)
annan publikation (1)
doktorsavhandling (1)
visa fler...
visa färre...
Typ av innehåll
refereegranskat (279)
övrigt vetenskapligt (14)
Författare/redaktör
Gudmundsson, Jón E. (38)
Lawrence, C. R. (38)
Burigana, C. (38)
Kurki-Suonio, H. (38)
Frailis, M. (37)
Zonca, A. (37)
visa fler...
Aumont, J. (37)
Baccigalupi, C. (37)
Banday, A. J. (37)
Barreiro, R. B. (37)
Bartolo, N. (37)
Benabed, K. (37)
Bersanelli, M. (37)
Bielewicz, P. (37)
Bouchet, F. R. (37)
Calabrese, E. (37)
Crill, B. P. (37)
Cuttaia, F. (37)
de Bernardis, P. (37)
de Zotti, G. (37)
Diego, J. M. (37)
Ducout, A. (37)
Dupac, X. (37)
Elsner, F. (37)
Ensslin, T. A. (37)
Finelli, F. (37)
Galeotta, S. (37)
Ganga, K. (37)
Gruppuso, A. (37)
Herranz, D. (37)
Jaffe, A. H. (37)
Keihanen, E. (37)
Keskitalo, R. (37)
Lamarre, J. -M. (37)
Lasenby, A. (37)
Lattanzi, M. (37)
Levrier, F. (37)
Lilje, P. B. (37)
Lopez-Caniego, M. (37)
Macias-Perez, J. F. (37)
Maggio, G. (37)
Martinez-Gonzalez, E ... (37)
Matarrese, S. (37)
Migliaccio, M. (37)
Morgante, G. (37)
Paoletti, D. (37)
Piacentini, F. (37)
Rachen, J. P. (37)
Reinecke, M. (37)
Remazeilles, M. (37)
visa färre...
Lärosäte
Lunds universitet (81)
Uppsala universitet (73)
Stockholms universitet (70)
Karolinska Institutet (66)
Göteborgs universitet (37)
Umeå universitet (32)
visa fler...
Chalmers tekniska högskola (9)
Kungliga Tekniska Högskolan (8)
Linnéuniversitetet (4)
Linköpings universitet (3)
Örebro universitet (2)
Sveriges Lantbruksuniversitet (2)
Luleå tekniska universitet (1)
Jönköping University (1)
Malmö universitet (1)
Mittuniversitetet (1)
Högskolan i Skövde (1)
Högskolan i Halmstad (1)
RISE (1)
Blekinge Tekniska Högskola (1)
Naturhistoriska riksmuseet (1)
visa färre...
Språk
Engelska (292)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (125)
Medicin och hälsovetenskap (121)
Lantbruksvetenskap (4)
Samhällsvetenskap (4)
Humaniora (3)
Teknik (2)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy