Sökning: WFRF:(Leboyer Marion)
> (2000-2004)
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Serotonin transport...
Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder
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Betancur, Catalina (författare)
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Marylis, Corbex (författare)
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Cécile, Spielewoy (författare)
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Anne, Phillipe (författare)
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Laplanche, Jean-Louis (författare)
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Jean-Marie, Launay (författare)
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- Gillberg, Christopher, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
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Mouren-Simeoni, Marie-Christine (författare)
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Hamon, Michel (författare)
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Bruno, Giros (författare)
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Nosten-Bertrand, Marika (författare)
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Leboyer, Marion (författare)
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visa färre...
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(creator_code:org_t)
- 2006-12-12
- 2002
- Engelska.
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 7:1, s. 67-71
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Previous studies have provided conflicting evidence regarding the association of the serotonin transporter (5-HTT) gene with autism. Two polymorphisms have been identified in the human 5-HTT gene, a VNTR in intron 21 and a functional deletion/insertion in the promoter region (5-HTTLPR) with short and long variants.2 Positive associations of the 5-HTTLPR polymorphism with autism have been reported by two family-based studies, but one found preferential transmission of the short allele3 and the other of the long allele.4 Two subsequent studies failed to find evidence of transmission disequilibrium at the 5-HTTLPR locus.5,6 These conflicting results could be due to heterogeneity of clinical samples with regard to serotonin (5-HT) blood levels, which have been found to be elevated in some autistic subjects.7–9 Thus, we examined the association of the 5-HTTLPR and VNTR polymorphisms of the 5-HTT gene with autism, and we investigated the relationship between 5-HTT variants and whole-blood 5-HT. The transmission/disequilibrium test (TDT) revealed no linkage disequilibrium at either loci in a sample of 96 families comprising 43 trios and 53 sib pairs. Furthermore, no significant relationship between 5-HT blood levels and 5-HTT gene polymorphisms was found. Our results suggest that the 5-HTT gene is unlikely to play a major role as a susceptibility factor in autism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Alleles
- Autistic Disorder
- Blood
- Genetics
- Blood Platelets
- Metabolism
- Carrier Proteins
- Genetics
- Physiology
- Child
- Child
- Preschool
- Female
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Haplotypes
- Genetics
- Humans
- Introns
- Genetics
- Linkage Disequilibrium
- Male
- Membrane Glycoproteins
- Genetics
- Physiology
- Membrane Transport Proteins
- Minisatellite Repeats
- Mutagenesis
- Insertional
- Nerve Tissue Proteins
- Polymorphism
- Genetic
- Risk Factors
- Sequence Deletion
- Serotonin
- Blood
- Serotonin Plasma Membrane Transport Proteins
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Betancur, Catali ...
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Marylis, Corbex
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Cécile, Spielewo ...
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Anne, Phillipe
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Laplanche, Jean- ...
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Jean-Marie, Laun ...
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Gillberg, Christ ...
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Mouren-Simeoni, ...
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Hamon, Michel
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Bruno, Giros
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Nosten-Bertrand, ...
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Leboyer, Marion
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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Molecular Psychi ...
- Av lärosätet
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Göteborgs universitet