Search: WFRF:(Leboyer Marion)
> (2000-2004)
> Penet Christiane >
Analysis of ten can...
Analysis of ten candidate genes in autism by association and linkage
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Philippe, Anne (author)
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Guilloud-Bataille, Michel (author)
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Martinez, Maria (author)
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- Gillberg, Christopher, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
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- Råstam, Maria, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
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Sponheim, Eili (author)
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Coleman, Mary (author)
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Zappella, Michele (author)
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Aschauer, Harald (author)
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Penet, Christiane (author)
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Feingold, Josué (author)
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Brice, Alexis (author)
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Leboyer, Marion (author)
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(creator_code:org_t)
- 2002-01-08
- 2002
- English.
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In: American Journal of Medical Genetics. - : Wiley. - 0148-7299. ; 114:2, s. 125-128
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family sample has good power for detecting a linkage disequilibrium of 0.80. Thus, these genes are unlikely to play a major role in the families studied, but further studies in a much larger sample would be needed to highlight weaker genetic effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alleles
- Autistic Disorder
- Genetics
- Chromosome Mapping
- DNA
- Genetics
- Family Health
- Female
- Genetic Predisposition to Disease
- Genetics
- Genotype
- Humans
- Linkage Disequilibrium
- Male
- Microsatellite Repeats
- Monoamine Oxidase
- Genetics
- Nuclear Family
- Receptors
- Dopamine
- Genetics
- Tyrosine 3-Monooxygenase
- Genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Philippe, Anne
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Guilloud-Bataill ...
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Martinez, Maria
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Gillberg, Christ ...
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Råstam, Maria, 1 ...
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Sponheim, Eili
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show more...
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Coleman, Mary
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Zappella, Michel ...
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Aschauer, Harald
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Penet, Christian ...
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Feingold, Josué
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Brice, Alexis
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Leboyer, Marion
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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American Journal ...
- By the university
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University of Gothenburg