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Studies on the Inte...
Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate
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- Lundberg, Dan, 1975 (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Lafitte, Géraldine (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Ljusberg, Helena (författare)
- Lund University,Lunds universitet,LU Innovation,Sektionen Forskning, samverkan och innovation,Universitetsförvaltningen,Universitetets ledning och förvaltning,Research, Collaboration and Innovation,Central Administration,University Management and Central Administration
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Lennernas, P. (författare)
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- Thuresson, Krister (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- Informa UK Limited, 2009
- 2009
- Engelska.
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Ingår i: Journal of Dispersion Science and Technology. - : Informa UK Limited. - 1532-2351 .- 0193-2691. ; 30:6, s. 920-928
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://research.cha...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- phase-behavior
- ussing chamber
- mixed micelles
- counterion binding
- in-vitro
- drug-delivery systems
- self-emulsifying drug-delivery system
- microemulsion
- diffusion
- cationic amphiphile
- light-scattering
- mucin
- gastrointestinal mucus
- Bioavailability
- nonionic surfactant
- self-emulsifying drug-delivery system
- mucin
- microemulsion
- Bioavailability
- cationic amphiphile
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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