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Comparing tau statu...
Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET
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Tissot, C. (author)
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Therriault, J. (author)
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Kunach, P. (author)
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- Lessa Benedet, Andréa (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Pascoal, T. A. (author)
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Ashton, N. J. (author)
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Servaes, S. (author)
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Lussier, F. Z. (author)
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Chamoun, M. (author)
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Tudorascu, D. L. (author)
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Stevenson, J. (author)
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Rahmouni, N. (author)
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Poltronetti, N. M. (author)
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Pallen, V. (author)
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Bezgin, G. (author)
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Kang, M. S. (author)
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Mathotaarachchi, S. S. (author)
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Wang, Y. T. (author)
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Fernandez Arias, J. (author)
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Ferreira, P. C. L. (author)
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Ferrari-Souza, J. P. (author)
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Vanmechelen, E. (author)
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Blennow, K. (author)
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Zetterberg, H. (author)
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Gauthier, S. (author)
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Rosa-Neto, P. (author)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Ebiomedicine. - : Elsevier BV. - 2352-3964. ; 76
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http://www.thelancet...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: Tau in Alzheimer's disease (AD) is assessed via cerebrospinal fluid (CSF) and Positron emission tomography (PET). Novel methods to detect phosphorylated tau (pTau) in blood have been recently developed. We aim to investigate agreement of tau status as determined by [18F]MK6240 tau-PET, plasma pTau181 and pTau231. Methods: We assessed cognitively unimpaired young, cognitively unimpaired, mild cognitive impairment and AD individuals with [18F]MK6240, plasma pTau181, pTau 231, [18F]AZD4694 amyloid-PET and MRI. A subset underwent CSF assessment. We conducted ROC curves to obtain cut-off values for plasma pTau epitopes. Individuals were categorized as positive or negative in all biomarkers. We then compared the distribution among concordant and discordant groups in relation to diagnosis, Aβ status, APOEε4 status, [18F]AZD4694 global SUVR, hippocampal volume and CSF pTau181. Findings: The threshold for positivity was 15.085 pg/mL for plasma pTau181 and 17.652 pg/mL for plasma pTau231. Most individuals had concordant statuses, however, 18% of plasma181/PET, 26% of plasma231/PET and 25% of the pTau231/pTau181 were discordant. Positivity to at least one biomarker was often accompanied by diagnosis of cognitive impairment, Aβ positivity, APOEε4 carriership, higher levels of [18F]AZD4694 global SUVR, hippocampal atrophy and CSF pTau181. Interpretation: Plasma pTau181, pTau231 and [18F]MK6240 seem to reflect different stages of tau progression. Plasma biomarkers can be useful in the context of diagnostic information and clinical trials, to evaluate the disease stage. Moreover, they seem to confidently evaluate tau-PET positivity. Funding: Moreover, this study was supported by Weston Brain Institute, Canadian Institute of Health Research and Fonds de Recherche du Québec. © 2022 The Authors
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Plasma
- Positron emission tomography
- Tau
- amyloid beta protein
- apolipoprotein E
- apolipoprotein E4
- biological marker
- florquinitau f 18
- phosphorylated tau 181
- phosphorylated tau 231
- tau protein
- unclassified drug
- adult
- Alzheimer disease
- amygdala
- area under the curve
- Article
- biofluid analysis
- blood sampling
- brain size
- cerebrospinal fluid
- cerebrospinal fluid analysis
- Clinical Dementia Rating
- cohort analysis
- comparative study
- controlled study
- diagnostic test accuracy study
- education
- female
- hippocampus
- human
- human tissue
- hypothalamus
- major clinical study
- male
- mild cognitive impairment
- Mini Mental State Examination
- molecular evolution
- nuclear magnetic resonance imaging
- phenotype
- prevalence
- protein blood level
- protein phosphorylation
- receiver operating characteristic
- risk assessment
- sensitivity and specificity
- standardized uptake value ratio
- threshold limit value
- white matter
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Tissot, C.
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Therriault, J.
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Kunach, P.
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Lessa Benedet, A ...
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Pascoal, T. A.
-
Ashton, N. J.
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show more...
-
Karikari, Thomas
-
Servaes, S.
-
Lussier, F. Z.
-
Chamoun, M.
-
Tudorascu, D. L.
-
Stevenson, J.
-
Rahmouni, N.
-
Poltronetti, N. ...
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Pallen, V.
-
Bezgin, G.
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Kang, M. S.
-
Mathotaarachchi, ...
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Wang, Y. T.
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Fernandez Arias, ...
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Ferreira, P. C. ...
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Ferrari-Souza, J ...
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Vanmechelen, E.
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Blennow, K.
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Zetterberg, H.
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Gauthier, S.
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Rosa-Neto, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Ebiomedicine
- By the university
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University of Gothenburg