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- Dong, Yi-Min, et al.
(författare)
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Reply to Collins et al
- 2021
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press. - 1058-4838 .- 1537-6591. ; 73:3, s. 558-559
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
- Martinsson, I, et al.
(författare)
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Aβ/APP-induced hyperexcitability and dysregulation of homeostatic synaptic plasticity in models of Alzheimer’s disease
- 2022
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The proper function of the nervous system is dependent on the appropriate timing of neuronal firing. Synapses continually undergo rapid activity-dependent modifications that require feedback mechanisms to maintain network activity within a window in which communication is energy efficient and meaningful. Homeostatic synaptic plasticity (HSP) and homeostatic intrinsic plasticity (HIP) are such negative feedback mechanisms. Accumulating evidence implicates that Alzheimer’s disease (AD)-related amyloid precursor protein (APP) and its cleavage product amyloid-beta (Aβ) play a role in the regulation of neuronal network activity, and in particular HSP. AD features impaired neuronal activity with regional early hyper-activity and Aβ-dependent hyperexcitability has also been demonstrated in AD transgenic mice. We demonstrate similar hyper-activity in AD transgenic neurons in culture that have elevated levels of both human APP and Aβ. To examine the individual roles of APP and Aβ in promoting hyperexcitability we used an APP construct that does not generate Aβ, or elevated Aβ levels independently of APP. Increasing either APP or Aβ in wild type (WT) neurons leads to increased frequency and amplitude of calcium transients. Since HSP/HIP mechanisms normally maintain a setpoint of activity, we examined whether homeostatic synaptic/intrinsic plasticity was altered in AD transgenic neurons. Using methods known to induce HSP/HIP, we demonstrate that APP protein levels are regulated by chronic modulation of activity and show that AD transgenic neurons have an impaired response to global changes in activity. Further, AD transgenic compared to WT neurons failed to adjust the length of their axon initial segments (AIS), an adaptation known to alter excitability. Thus, we present evidence that both APP and Aβ influence neuronal activity and that mechanisms of HSP/HIP are disrupted in neuronal models of AD.Competing Interest StatementThe authors have declared no competing interest.
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| 4. |
- Shen, Jue, et al.
(författare)
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Interactive UHF/UWB RFID Tag for Mass Customization
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Mass customization (MC) under the context ofthe Internet of Things (IoT) is expected to reform traditionalmass manufacturing. To contribute to MC from information communication and user interaction aspects, this work proposes an Ultra-High Frequency (UHF) RFID tag with Impulse-Radio Ultra-Wide Band (IR UWB) transmitter and inkjet-printed Electrochromic (EC) display. First, compared to conventional UHF RFID tags, the proposed tag shows advantages of higher data rate while still keeping low power consumption. A modified communication protocol for such tag is proposed to decrease the response time in multi-tag accessing scenarios to less than 500 ms/1000 tags by the pipeline of IR UWB transmission of tag response and UHF RFID reception of reader acknowledgement and by reducingthe length of empty slots. Secondly, the tag is integrated with a flexible Electro-chromic (EC) display manufactured by inkjet-printing on the polyimide substrate. The tag with the display works as an automatically refreshed paper label which offers an intuitive human-to-device interface to improve the efficiency of the offline workers. To conquer material variation while make use of long retention time of the printed EC display, the threshold voltage of EC display is utilized and a feedback comparator is designed to start refreshing EC display based on the threshold voltage. For functional verification, a Silicon-on-Chip (SoC) is implementedin UMC 180 nm CMOS process. According to experimental results: 1) the IR UWB transmitter shows performances of 1.02 V pulse amplitude, 900 ps pulse duration and 18 pJ/pulse energy consumption; 2) the EC display driver with a feedback comparator automatically starts to refresh display when the image fades out, and reduces the power consumption for retaining image to 1.98 mW per 1 cm2 display size. The UHF/UWB RFID display tag integrated on polyimide substrate is conceptually demonstrated at the end of the paper.
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