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Sökning: WFRF:(Li Ming) > Högskolan i Halmstad

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  • 2019
  • Tidskriftsartikel (refereegranskat)
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2.
  • Shen, Weixing, et al. (författare)
  • Protective effects of Wang-Bi tablet on bone destruction in collagen-induced arthritis by regulating osteoclast-osteoblast functions.
  • 2019
  • Ingår i: Journal of Ethnopharmacology. - : Elsevier BV. - 0378-8741 .- 1872-7573. ; 238
  • Tidskriftsartikel (refereegranskat)abstract
    • ETHNOPHARMACOLOGICAL RELEVANCE: Wang-bi tablet (WB) consists of 17 traditional Chinese medicines and has been used for treating rheumatoid arthritis (RA) in China for many years, however, its pharmacologic mechanism is not clear.AIM OF STUDY: The aim of this study was to investigate the therapeutic effect of WB on collagen-induced mouse arthritis and explored the underlying mechanism.MATERIALS AND METHODS: DBA/1 mice were used to establish a type II collagen-induced arthritis (CIA) model. From the day of arthritis onset, mice were treated daily by gavage with either total glucosides of paeony (TGP, 0.37  g/kg/d) or WB at a lower (1.11  g/kg/d, WBL) or higher dose of (3.33  g/kg/d, WBH) for 8 weeks. The severity of arthritis, levels of cytokines and the activation of signaling pathways were determined.RESULTS: Our results revealed that WB treatment effectively alleviated inflammatory symptoms and prevented bone erosions and joint destructions. It obviously decreased the serum concentration of pro-inflammatory cytokines TNF-α, IL-6 and IL-17α, while increased the concentration of anti-inflammatory cytokine IL-10. Interestingly, the proportion of splenic Treg cells were increased significantly. In vitro experiments showed that WB inhibited the differentiation of osteoclasts. Consistently, the mRNA levels of tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CtsK), and the activation of NF-κB and JAK-STAT3 signaling pathways in the paws of CIA mice were inhibited by WB treatment. On the other hand, up-regulation of osteogenic genes Runx2, Osterix mRNA, and activation of Wnt/β-catenin signaling pathway along with a decreased receptor activator of nuclear factor κB ligand (RANKL) expression were found in WB treated mice.CONCLUSION: Our results suggest that the therapeutic effect of Wang-bi tablet could be attributed to its inhibitory activity on NF-κB and STAT3 signaling pathway-mediated osteoclast differentiation, and its enhancement on Wnt/β-catenin signaling pathway-mediated osteoblast functions.
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4.
  • Zhang, Ke, et al. (författare)
  • Optimal energy exchange schemes in smart grid networks : A contract theoretic approach
  • 2016
  • Ingår i: 2016 IEEE/CIC International Conference on Communications in China (ICCC). - Piscataway, NJ : IEEE. - 9781509021437 - 9781509021444
  • Konferensbidrag (refereegranskat)abstract
    • Vehicle-to-Grid (V2G) is a promising paradigm to alleviate energy supply and demand imbalance of the grid. To further improve the power transmission efficiency, in this paper, we propose a cloudlet-based Vehicle-to-Vehicle (V2V) energy exchange framework. In the framework, the Energy Switch Center (ESC) serves as a trading broker, which purchases electricity from discharging vehicles and then resells it to the charging ones without energy transmission on the grid. The energy trading process is modeled in a contract theoretic approach. We derive the optimal feasible contracts which maximize the profit of the ESC. Furthermore, we systematically study the practical scenario where both the charging demand and renewable energy supplement are random variables, and propose a practical optimal contract-based electricity purchase scheme. Simulation results show that the proposed scheme can efficiently increase the profit of the ESC than the other mechanisms. © 2016 IEEE.
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