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Träfflista för sökning "WFRF:(Li Peng) ;lar1:(lnu)"

Sökning: WFRF:(Li Peng) > Linnéuniversitetet

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1.
  • Li, Jing, et al. (författare)
  • Teaching algebraic equations with variation in Chinese classroom
  • 2011
  • Ingår i: Early Algebraization. - Berlin, Heidelberg : Springer. - 9783642177347 ; , s. 529-556
  • Bokkapitel (refereegranskat)abstract
    • This chapter gives a detailed analysis of how teaching with variation is helpful for students’ learning of algebraic equations by using typical teaching episodes in grade seven in China. Also, it provides a demonstration showing how variation is used as an effective way of teaching through the discussion after the analysis.
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2.
  • Peng, Aihui, et al. (författare)
  • Swedish and Chinese teachers' views on what constitutes a good mathematical test task : A pilot study
  • 2015
  • Ingår i: Proceedings of CERME 9. - : European Society for Research in Mathematics Education. ; , s. 1738-1744
  • Konferensbidrag (refereegranskat)abstract
    • Mathematical tasks in tests are central to students’ learning.Research shows that there is a significant gap between mathematical tasks in national tests and teacher-made tests.In this pilot study we examineeighteenSwedish and Chinese teachers’ viewsonwhat constitutes of a good mathematicaltesttaskat thelowersecondary school level. E-Mail Interviewing is conducted by presenting sevenmathematical tasks from national tests inSweden and China, respectively. The preliminary results show that Swedish and Chinese teachers hold some common viewsonthecharacteristics of good mathematical test tasks, but they also show different viewson the cognitively demanding tasks. Implications of the results and the methodology informed by the pilot study are discussed.
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3.
  • Snyder, Gretchen L., et al. (författare)
  • Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats
  • 2016
  • Ingår i: Psychopharmacology. - : Springer Science and Business Media LLC. - 0033-3158 .- 1432-2072. ; 233:17, s. 3113-3124
  • Tidskriftsartikel (refereegranskat)abstract
    • Rationale: Therapeutic agents for memory enhancement in psychiatric disorders, such as schizophrenia, are urgently needed.Objective: The aim of this study is to characterize the preclinical profile of ITI-214, a potent inhibitor of phosphodiesterase 1 (PDE1).Methods: ITI-214 was assayed for inhibition of PDE1 versus other PDE enzyme families using recombinant human PDE enzymes and for off-target binding to 70 substrates (General SEP II diversity panel; Caliper Life Sciences). Effects of ITI-214 (0.1–10 mg/kg, po) on memory performance were assayed in rats using the novel object recognition (NOR) paradigm, with drug given at specified time points prior to or following exposure to objects in an open field. ITI-214 was evaluated for potential drug-drug interaction with risperidone in rats using conditioned avoidance response (CAR) and pharmacokinetic assessments.Results: ITI-214 inhibited PDE1A (Ki = 33 pmol) with >1000-fold selectivity for the nearest other PDE family (PDE4D) and displayed minimal off-target binding interactions in a 70-substrate selectivity profile. By using specific timing of oral ITI-214 administration, it was demonstrated in the NOR that ITI-214 is able to enhance acquisition, consolidation, and retrieval memory processes. All memory effects were in the absence of effects on exploratory behavior. ITI-214 did not disrupt the risperidone pharmacokinetic profile or effects in CAR.Conclusions: ITI-214 improved the memory processes of acquisition, consolidation, and retrieval across a broad dose range (0.1–10 mg/kg, po) without disrupting the antipsychotic-like activity of a clinical antipsychotic medication, specifically risperidone. Clinical development of ITI-214 is currently in progress.
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