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- Winkler, TW, et al.
(författare)
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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
- 2022
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 580-
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Tidskriftsartikel (refereegranskat)abstract
- Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
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| 2. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 4. |
- Li, Jun, et al.
(författare)
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An efficient and reliable approach for quality-of-service-aware service composition
- 2014
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Ingår i: Information Sciences. - : Elsevier. - 0020-0255 .- 1872-6291. ; 269, s. 238-254
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Tidskriftsartikel (refereegranskat)abstract
- With the rapidly increasing number of independently developed Web services that provide similar functionalities with varied quality of service (QoS), service composition is considered as a problem in the selection of component services that are in accordance with users' QoS requirements; a practice known as the QoS-aware service composition problem. However, current solutions are unsuitable for most real-time decision-making service composition applications required to obtain a relatively optimal result within a reasonable amount of time. These services are also unreliable (or even risky) given the open service-oriented environment. In this paper, we address these problems and propose a novel heuristic algorithm for an efficient and reliable selection of trustworthy services in a service composition. The proposed algorithm consists of three steps. First, a trust-based selection method is used to filter untrustworthy component services. Second, convex hulls are constructed to reduce the search space in the process of service composition. Finally, a heuristic global optimization approach is used to obtain the near-optimal solution. The results demonstrate that our approach obtains a close-to-optimal and reliable solution within a reasonable computation time.
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