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| 2. |
- Bergman, Jan, et al.
(författare)
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Reactions of 1,2-bis(1H-indol-2-yl)ethane : Formation of indolo[2,3-c]carbazole and cyclohept[1,2-b : 5,4-b ']bisindole derivatives
- 2000
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Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 56:13, s. 1911-1916
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Tidskriftsartikel (refereegranskat)abstract
- 1,2-Bis(1H-indol-2-yl)ethane (9) has been prepared and converted into indolo[2,3-c]carbazole (8) using palladium acetate in refluxing acetic acid. Reaction of 9 with CoF3 in hot TFA led to isolation of cyclohept[1,2-b:5,4-b']bisindole derivatives 11 and 12, which could be elaborated into further derivatives. Treatment of 9 with orthoesters, aldehydes and ketones under acidic conditions afforded additional bisindoles containing a seven-membered ring.
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| 3. |
- Raina, D. B., et al.
(författare)
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Bone mineral as a drug-seeking moiety and a waste dump a Review
- 2020
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Ingår i: Bone and Joint Research. - 2046-3758. ; 9:10, s. 709-718
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Forskningsöversikt (refereegranskat)abstract
- Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health.
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| 4. |
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| 5. |
- Bergman, Jan, et al.
(författare)
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Synthesis of indolocarbazole quinones; potent aryl hydrocarbon receptor ligands
- 2002
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Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 58:7, s. 1443-1452
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Tidskriftsartikel (refereegranskat)abstract
- Syntheses of indolo[2,3-b]carbazole-6,12-dione and the isomeric indolo[3,2-b]carbazole-6,12-dione, an extremely efficient inducer of the aryl hydrocarbon (Ah) receptor are described. Initial oxidation of the parent indolo[3,2-b]carbazole followed by several different ring-closing strategies produced the latter compound. Entries into syntheses of unsymmetrical 6,12-disubstituted indolo[2,3-b]carbazoles are also described.
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| 7. |
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| 8. |
- Lewold, S, et al.
(författare)
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Overall cancer incidence not increased after prosthetic knee replacement : 14,551 patients followed for 66,622 person-years
- 1996
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Ingår i: International Journal of Cancer. - 0020-7136. ; 68:1, s. 3-30
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Tidskriftsartikel (refereegranskat)abstract
- It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.
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| 9. |
- Lidgren, L, et al.
(författare)
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Automatic fermentation control based on a real-time in situ SIRE (R) biosensor regulated glucose feed
- 2006
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Ingår i: Biosensors & Bioelectronics. - : Elsevier BV. - 1873-4235 .- 0956-5663. ; 21:10, s. 2010-2013
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Tidskriftsartikel (refereegranskat)abstract
- Monitoring and regulation of fermentations is of a paramount industrial and academic importance in order to keep conditions optimal during the entire process. Established techniques employed today include HPLC and spectrophotometry, which both have the disadvantage that broth samples have to be drawn from the fermentor and that they often require sample pre-treatment. The objectives of this study was to design and evaluate a software controlled automatic real-time SIRE (R) biosensor connected to a glucose feed solution pump for in situ based monitoring and regulation of the glucose concentration during a yeast fermentation process. The maximal frequency for the measuring-regulation cycles was 30/h. A 10 mM mean glucose concentration level was successfully maintained within +/- 0.013 mM during 60 min fermentations at various concentrations of yeast (10, 20, 40 and 80 g/l). The on/off-regulator used caused some expected fluctuations (oscillations) of the glucose concentration around the mean value (0.12 mM at 10 g/l, +/- 0.26 mM at 20 g/l, +/- 0.51 mM at 40 g/l, and +/- 0.99 mM at 80 g/l). A 7-h fermentation process (10 mM glucose and 20 g/l yeast) was successfully monitored and regulated. The obtained measuring data were found to be 8.5-22.9% lower than data obtained with a commercially available spectrophotometric kit. The difference increased linearly (-0.26 mM/h), during the fermentation process and indicated that some clogging of the in situ positioned probe occurred. The speed and the automatisation adaptability of the presented device suggest advantages compared to established techniques.
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| 10. |
- Nilsson, M, et al.
(författare)
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Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute.
- 2004
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Ingår i: Journal of Bone and Joint Surgery: British Volume. - 2044-5377. ; 86:1, s. 120-125
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Tidskriftsartikel (refereegranskat)abstract
- An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces of the material and this may enhance bone ingrowth.
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