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Sökning: WFRF:(Liehua Liu)

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  • Liu, Liehua, et al. (författare)
  • Dipeptidyl peptidase-4 (DPP-4): Localization and activity in human and rodent islets.
  • 2014
  • Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier. - 1090-2104. ; 453:3, s. 398-404
  • Tidskriftsartikel (refereegranskat)abstract
    • Dipeptidyl peptidase 4 (DPP-4) was recently found to be expressed in human and mouse islets with different expression patterns. However, whether species-dependent expression pattern is a generalized phenomenon and whether islet DPP-4 activity is regulated are not known. This study was conducted to investigate DPP-4 localization in several different species, and to examine the impact of glucose, incretin hormones, and insulin on islet DPP-4 activity. It was shown by immuofluorescent staining that there were two distinct species-specific expression patterns of islet DPP-4. The enzyme was expressed exclusively in α-cells in human and pig islets, but primarily in β-cells in mouse and rat islets. INS-1 832/13 cells also expressed DPP-4, and inhibition of DPP-4 enhanced insulin secretion in the presence of glucagon-like peptide-1 (GLP-1) in the cells. DPP-4 activity was remarkably robust when cultured with high glucose, incretin hormones, and insulin in mouse and human islets as well as INS-1 832/13 cells and islet DPP-4 activity and expression pattern was not altered in double incretin receptor knockout mice, compared to wild type mice. We conclude that islet DPP-4 is species-specifically expressed in α-cell and β-cell dominant patterns in several species and both patterns remained robust in enzyme activity during short-term metabolic challenge.
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Ahrén, Bo (2)
Omar, Bilal (2)
Marchetti, Piero (2)
Yamada, Yuchiro (1)
Seino, Yutaka (1)
Liu, Liehua (1)
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Liehua, Liu (1)
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