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Sökning: WFRF:(Liehua Liu) > (2014) > Tidskriftsartikel

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1.	Liu, Liehua, et al. (författare) Dipeptidyl peptidase-4 (DPP-4): Localization and activity in human and rodent islets. 2014 Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 453:3, s. 398-404 Tidskriftsartikel (refereegranskat)abstract Dipeptidyl peptidase 4 (DPP-4) was recently found to be expressed in human and mouse islets with different expression patterns. However, whether species-dependent expression pattern is a generalized phenomenon and whether islet DPP-4 activity is regulated are not known. This study was conducted to investigate DPP-4 localization in several different species, and to examine the impact of glucose, incretin hormones, and insulin on islet DPP-4 activity. It was shown by immuofluorescent staining that there were two distinct species-specific expression patterns of islet DPP-4. The enzyme was expressed exclusively in α-cells in human and pig islets, but primarily in β-cells in mouse and rat islets. INS-1 832/13 cells also expressed DPP-4, and inhibition of DPP-4 enhanced insulin secretion in the presence of glucagon-like peptide-1 (GLP-1) in the cells. DPP-4 activity was remarkably robust when cultured with high glucose, incretin hormones, and insulin in mouse and human islets as well as INS-1 832/13 cells and islet DPP-4 activity and expression pattern was not altered in double incretin receptor knockout mice, compared to wild type mice. We conclude that islet DPP-4 is species-specifically expressed in α-cell and β-cell dominant patterns in several species and both patterns remained robust in enzyme activity during short-term metabolic challenge.
2.	Omar, Bilal, et al. (författare) Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes. 2014 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 57:9, s. 1876-1883 Tidskriftsartikel (refereegranskat)abstract Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4), which cleaves and inactivates glucagon-like peptide 1 (GLP-1), is a glucose-lowering strategy in type 2 diabetes. Since DPP-4 is a ubiquitously distributed enzyme, we examined whether it is expressed in islets and whether an islet effect to inhibit DPP-4 may result in stimulated insulin secretion.

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Typ av publikation: tidskriftsartikel (2)Ta bort avgränsningen

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Ahren, Bo (2); Omar, Bilal (2); Marchetti, Piero (2); Yamada, Yuchiro (1); Seino, Yutaka (1); Liu, Liehua (1); visa fler...; Liehua, Liu (1); visa färre...

Lärosäte: Lunds universitet (2)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Naturvetenskap (1); Medicin och hälsovetenskap (1)

År: 2014 (2)Ta bort avgränsningen

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