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- Ding, Yang, et al.
(författare)
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Artificial intelligence-assisted point-of-care testing system for ultrafast and quantitative detection of drug-resistant bacteria
- 2024
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Ingår i: SMARTMAT. - : WILEY. - 2766-8525. ; 5:3
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Tidskriftsartikel (refereegranskat)abstract
- As one of the major causes of antimicrobial resistance, beta-lactamase develops rapidly among bacteria. Detection of beta-lactamase in an efficient and low-cost point-of-care testing (POCT) way is urgently needed. However, due to the volatile environmental factors, the quantitative measurement of current POCT is often inaccurate. Herein, we demonstrate an artificial intelligence (AI)-assisted mobile health system that consists of a paper-based beta-lactamase fluorogenic probe analytical device and a smartphone-based AI cloud. An ultrafast broad-spectrum fluorogenic probe (B1) that could respond to beta-lactamase within 20 s was first synthesized, and the detection limit was determined to be 0.13 nmol/L. Meanwhile, a three-dimensional microfluidic paper-based analytical device was fabricated for integration of B1. Also, a smartphone-based AI cloud was developed to correct errors automatically and output results intelligently. This smart system could calibrate the temperature and pH in the beta-lactamase level detection in complex samples and mice infected with various bacteria, which shows the problem-solving ability in interdisciplinary research, and demonstrates potential clinical benefits.
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- Jonnalagadda, Krisha Praveen, 1988-, et al.
(författare)
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Comparison of Damage Evolution During Thermal Cycling in a High Purity Nano and Conventional Thermal Barrier Coating
- 2017
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Ingår i: Surface & Coatings Technology. - : Elsevier. - 0257-8972 .- 1879-3347. ; 332, s. 47-56
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Tidskriftsartikel (refereegranskat)abstract
- Thermal barrier coatings (TBCs), consisting of a ceramic top coat and a metallic bond coat, offer resistance against high temperature degradation of turbine components. Cyclic oxidation of the bond coat, thermal stresses due to their thermal mismatches during cyclic operations, and sintering of the top coat are considered to be the common ways by which thermal barrier coatings fail. To reduce sintering, a nano structured high purity yttria stabilized zirconia (YSZ) was developed. The focus of this work is to compare the damage development of such high purity nano YSZ TBC during thermal cycling with a conventional YSZ TBC. Thermal cyclic fatigue (TCF) tests were conducted on both the TBC systems between 100 °C and 1100 °C with a 1 h hold time at 1100 °C. TCF test results showed that conventional YSZ TBC exhibited much higher life compared to the high purity nano YSZ TBC. The difference in the lifetime is explained by the use of microstructural investigations, crack length measurements along the cross-section and the difference in the elastic modulus. Furthermore, stress intensity factors were calculated in order to understand the difference(s) in the damage development between the two TBC systems.
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- Jonnalagadda, Krishna Praveen, 1988-, et al.
(författare)
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Influence of Top Coat and Bond Coat Pre-Oxidation on the Corrosion Resistance of Thermal Barrier Coatings in the Presence of SO2
- 2018
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Ingår i: PROCEEDINGS OF THE ASME TURBO EXPO: TURBOMACHINERY TECHNICAL CONFERENCE AND EXPOSITION, 2018, VOL 6. - : AMER SOC MECHANICAL ENGINEERS. - 9780791851128
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Konferensbidrag (refereegranskat)abstract
- Thermal barrier coatings (TBCs) degradation due to corrosion is one of the commonly observed failure types in land-based gas turbines due to the usage of low grade fuels. Sulfur in its gaseous form, as SO2, can attack the TBC system and result in the degradation of both the coating and the turbine component. The present study aims to understand the difference in the corrosion induced damage caused by SO2 gas mixture in different coating architectures. Corrosion tests were conducted at 780 degrees C in a tube furnace for a period of 168h. The inlet test gas had a composition of 1SO(2)-0.1CO-20CO(2)-N-2 (bal.) in vol. %. The coating architectures consisted of 1) an overlay coating, 2) a single-side bond coat TBC, 3) an all-side bond coat TBC, 4) an all-side bond coat TBC subjected to pre-oxidation prior to the corrosion tests. The results from the corrosion tests showed that the damage was the most severe for the overlay followed by single-side bond coat TBC. Between the other two systems, the TBC subjected to pre-oxidation had relatively lower corrosion damage. The corrosion damage started from the edges for the overlay and single-side bond coat TBC and as well as through the penetration of the gas through the coating. For the coatings with bond coat on all sides, the edge damage appeared to be considerably reduced and the damage is predominantly through the gas infiltration.
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- Lee, Samantha Lin Chiou, et al.
(författare)
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Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
- 2009
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:46, s. 19485-19490
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Tidskriftsartikel (refereegranskat)abstract
- Mechanisms underlying pathological angiogenesis in relation to hypoxia in tumor invasion and metastasis remain elusive. Here, we have developed a zebrafish tumor model that allows us to study the role of pathological angiogenesis under normoxia and hypoxia in arbitrating early events of the metastatic cascade at the single cell level. Under normoxia, implantation of a murine T241 fibrosarcoma into the perivitelline cavity of developing embryos of transgenic fli1:EGFP zebrafish did not result in significant dissemination, invasion, and metastasis. In marked contrast, under hypoxia substantial tumor cells disseminated from primary sites, invaded into neighboring tissues, and metastasized to distal parts of the fish body. Similarly, expression of the hypoxia-regulated angiogenic factor, vascular endothelial growth factor (VEGF) to a high level resulted in tumor cell dissemination and metastasis, which correlated with increased tumor neovascularization. Inhibition of VEGF receptor signaling pathways by sunitinib or VEGFR2 morpholinos virtually completely ablated VEGF-induced tumor cell dissemination and metastasis. To the best of our knowledge, hypoxia- and VEGF-induced pathological angiogenesis in promoting tumor dissemination, invasion, and metastasis has not been described perviously at the single cell level. Our findings also shed light on molecular mechanisms of beneficial effects of clinically available anti-VEGF drugs for cancer therapy.
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- Li, Fenghong, et al.
(författare)
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Modified Surface Electronic and Magnetic Properties of La(0.6)Sr(0.4)MnO(3) Thin Films for Spintronics Applications
- 2011
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Ingår i: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 115:34, s. 16947-16953
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Tidskriftsartikel (refereegranskat)abstract
- We present the surface electronic and magnetic properties of half-metal La(0.6)Sr(0.4)MnO(3) (LSMO) thin film modified by a simple cleaning procedure, the so-called SC1 (5 H(2)O, 1 NH(4)OH, I H(2)O(2)), at 85 degrees C for 10-40 min in ambient atmosphere. In this study, photoemission spectroscopy (XPS/UPS), X-ray absorption spectroscopy (XAS), and X-ray magnetic circular dichroism (XMCD) are used to characterize these properties of the manganites. Thanks to SC1 treatment, the work function of LSMO changes from 4.0-4.1 to 4.8-4.9 eV obtained from UPS measurements, while its surface roughness changes from 0.268 to 0.796 nm in AFM images. Combined 0 1s, Mn 2p, Sr 3d, La 4d, and Mn 3s core-level XPS spectroscopy investigations suggest that Mn and Sr contents decrease at the surface and the Mn value becomes 3.7 due to SC1 treament. Mn L-edge XAS spectra of LSMO thin film demonstrate that SC1 treatment results in a removal of Mn(2+) and an increase of the Mn(4+) concentration. OK-edge XAS spectra further prove an enhancement of hybridization between O 2p orbitals and e(g)down arrow, of Mn 3d induced by more Mn(4+). XMCD results show that SC1 treatment does not induce any drastic changes of magnetic properties of the LSMO thin film surface.
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- Xin, Tongzheng, et al.
(författare)
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Phase transformations in an ultralight BCC Mg alloy during anisothermal ageing
- 2022
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Ingår i: Acta Materialia. - : PERGAMON-ELSEVIER SCIENCE LTD. - 1359-6454 .- 1873-2453. ; 239
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Tidskriftsartikel (refereegranskat)abstract
- Mg-Li-Al alloys with a body-centred cubic (BCC) structure can exhibit exceptional specific strengths in combination with excellent ductility and corrosion resistance. In general, the strength of these alloys is very sensitive to the processing temperature due to the occurrence of various phase transformations. Although different phases have been identified in these alloys, their corresponding transformation mechanisms and unique role played in controlling the mechanical properties have never been studied in depth. In this work, we identified the phase transformation sequence by in-situ synchrotron X-ray diffraction. Moreover, we investigated the evolution of precipitation and their morphology using transmission and scanning electron microscopy, together with simulations based on the phase field modelling and first-principles calculations. Phase transformation sequence of Al-rich zone?->?theta (D0(3)(-)Mg(3)Al)?->?AlLi was confirmed during anisothermal ageing. A braided structure resulting from spinodal decomposition was found to be the optimized microstructure for achieving the peak strength. Nanocrystalline alpha-Mg phase at the interface between theta and the matrix was identified as the main reason for softening in the alloy. The core-shell model for theta?->?AlLi transformation is observed and verified. Our findings deepen the understanding of BCC Mg-Li-Al alloys and pave a pathway to develop new generation of ultralight alloys with stronger strength and better stability. (C) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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