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- Ayesa, S., et al.
(författare)
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CYSTEINE PROTEASE INHIBITORS
- 2011
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Patent (populärvet., debatt m.m.)abstract
- Compounds of the formula IwhereinR1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; orR2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl;R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl,R4 is Het, Carbocyclyl,optionally substituted as defined in the specification and pharmaceutically acceptable salts,hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.
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- Batalden, Paul B., et al.
(författare)
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Episode 7: The web I tend [podcast]
- 2022
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Annan publikation (populärvet., debatt m.m.)abstract
- Living with a long term condition that begins at birth involves so many unplanned needs. It invites a diverse set of resources to help. Putting them all together to support the flourishing of a person involves building and integrating new knowledge. If a condition is present from birth, everything changes as the child grows and develops. Cristin’s experience helping her son, Gabriel, invites us to understand the journey.
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