SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lind Bengt) "

Sökning: WFRF:(Lind Bengt)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Alevronta, Eleftheria, et al. (författare)
  • Dose-response relationships for an atomized symptom of fecal incontinence after gynecological radiotherapy.
  • 2013
  • Ingår i: Acta oncologica (Stockholm, Sweden). - 1651-226X. ; 52:4, s. 719-26
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose. The aim of this study was to investigate what bowel organ and delivered dose levels are most relevant for the development of 'emptying of all stools into clothing without forewarning' so that the related dose-responses could be derived as an aid in avoiding this distressing symptom in the future. Material and methods. Of the 77 gynecological cancer survivors treated with radiotherapy (RT) for gynecological cancer, 13 developed the symptom. The survivors were treated between 1991 and 2003. The anal-sphincter region, the rectum, the sigmoid and the small intestines were all delineated and the dose-volume histograms were exported for each patient. The dose-volume parameters were estimated fitting the data to the Relative Seriality (RS), the Lyman and the generalized Equivalent Uniform Dose (gEUD) model. Results. The dose-response parameters for all three models and four organs at risk (OARs) were estimated. The data from the sigmoid fits the studied models best: D50 was 58.8 and 59.5 Gy (RS, Lyman), γ50 was 1.60 and 1.57 (RS, Lyman), s was 0.32, n was 0.13 and a was 7.7 (RS, Lyman, gEUD). The estimated volume parameters indicate that the investigated OARs behave serially for this endpoint. Our results for the three models studied indicate that they have the same predictive power (similar LL values) for the symptom as a function of the dose for all investigated OARs. Conclusions. In our study, the anal-sphincter region and sigmoid fit our data best, but all OARs were found to have steep dose-responses for 'emptying of all stools into clothing without forewarning' and thus, the outcome can be predicted with an NTCP model. In addition, the dose to the four studied OARs may be considered when minimizing the risk of the symptom.
  •  
2.
  •  
3.
  •  
4.
  • Eriksdotter-Jönhagen, Maria, et al. (författare)
  • Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.
  • 2012
  • Ingår i: Dementia and geriatric cognitive disorders. - 1421-9824. ; 33:1, s. 18-28
  • Tidskriftsartikel (refereegranskat)abstract
    • Degeneration of cholinergic neurons in the basal forebrain correlates with cognitive decline in patients with Alzheimer's disease (AD). Targeted delivery of exogenous nerve growth factor (NGF) has emerged as a potential AD therapy due to its regenerative effects on the basal forebrain cholinergic neurons in AD animal models. Here we report the results of a first-in-man study of encapsulated cell (EC) biodelivery of NGF to the basal forebrain of AD patients with the primary objective to explore safety and tolerability.
  •  
5.
  • Eyjolfsdottir, Helga, et al. (författare)
  • Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients application of a second-generation encapsulated cell biodelivery device
  • 2016
  • Ingår i: Alzheimer's Research & Therapy. - 1758-9193. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background: Targeted delivery of nerve growth factor (NGF) has emerged as a potential therapy for Alzheimer's disease (AD) due to its regenerative effects on basal forebrain cholinergic neurons. This hypothesis has been tested in patients with AD using encapsulated cell biodelivery of NGF (NGF-ECB) in a first-in-human study. We report our results from a third-dose cohort of patients receiving second-generation NGF-ECB implants with improved NGF secretion. Methods: Four patients with mild to moderate AD were recruited to participate in an open-label, phase Ib dose escalation study with a 6-month duration. Each patient underwent stereotactic implant surgery with four NGF-ECB implants targeted at the cholinergic basal forebrain. The NGF secretion of the second-generation implants was improved by using the Sleeping Beauty transposon gene expression technology and an improved three-dimensional internal scaffolding, resulting in production of about 10 ng NGF/device/day. Results: All patients underwent successful implant procedures without complications, and all patients completed the study, including implant removal after 6 months. Upon removal, 13 of 16 implants released NGF, 8 implants released NGF at the same rate or higher than before the implant procedure, and 3 implants failed to release detectable amounts of NGF. Of 16 adverse events, none was NGF-, or implant-related. Changes from baseline values of cholinergic markers in cerebrospinal fluid (CSF) correlated with cortical nicotinic receptor expression and Mini Mental State Examination score. Levels of neurofilament light chain (NFL) protein increased in CSF after NGF-ECB implant, while glial fibrillary acidic protein (GFAP) remained stable. Conclusions: The data derived from this patient cohort demonstrate the safety and tolerability of sustained NGF release by a second-generation NGF-ECB implant to the basal forebrain, with uneventful surgical implant and removal of NGF-ECB implants in a new dosing cohort of four patients with AD.</p>
  •  
6.
  • Akner, Gunnar, 1953-, et al. (författare)
  • Vi står gärna bakom en utfallsbaserad vård
  • 2017
  • Ingår i: Dagens Samhälle. - 1652-6511.
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • <p>Jörgen Nordenström försöker få det till att vår kritik av värdebaserad vård egentligen handlar om att vi vill ha mer resurser. Han har helt missuppfattat oss, skriver 26 specialistläkare i en replik.</p>
  •  
7.
  •  
8.
  • Alevronta, Eleftheria, et al. (författare)
  • Dose-response relationships for an atomized symptom of fecal incontinence after gynecological radiotherapy.
  • 2013
  • Ingår i: Acta Oncologica. - Taylor & Francis. - 0284-186X .- 1651-226X. ; 52:4, s. 719-26
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>PURPOSE:</strong> The aim of this study was to investigate what bowel organ and delivered dose levels are most relevant for the development of 'emptying of all stools into clothing without forewarning' so that the related dose-responses could be derived as an aid in avoiding this distressing symptom in the future.</p><p><strong>MATERIAL AND METHODS:</strong> Of the 77 gynecological cancer survivors treated with radiotherapy (RT) for gynecological cancer, 13 developed the symptom. The survivors were treated between 1991 and 2003. The anal-sphincter region, the rectum, the sigmoid and the small intestines were all delineated and the dose-volume histograms were exported for each patient. The dose-volume parameters were estimated fitting the data to the Relative Seriality (RS), the Lyman and the generalized Equivalent Uniform Dose (gEUD) model.</p><p><strong>RESULTS:</strong> The dose-response parameters for all three models and four organs at risk (OARs) were estimated. The data from the sigmoid fits the studied models best: D50 was 58.8 and 59.5 Gy (RS, Lyman), γ50 was 1.60 and 1.57 (RS, Lyman), s was 0.32, n was 0.13 and a was 7.7 (RS, Lyman, gEUD). The estimated volume parameters indicate that the investigated OARs behave serially for this endpoint. Our results for the three models studied indicate that they have the same predictive power (similar LL values) for the symptom as a function of the dose for all investigated OARs.</p><p><strong>CONCLUSIONS:</strong> In our study, the anal-sphincter region and sigmoid fit our data best, but all OARs were found to have steep dose-responses for 'emptying of all stools into clothing without forewarning' and thus, the outcome can be predicted with an NTCP model. In addition, the dose to the four studied OARs may be considered when minimizing the risk of the symptom.</p>
  •  
9.
  • Alevronta, Eleftheria, et al. (författare)
  • Time-dependent dose-response relation for absence of vaginal elasticity after gynecological radiation therapy
  • 2016
  • Ingår i: Radiotherapy and Oncology. - ELSEVIER IRELAND LTD. - 0167-8140 .- 1879-0887. ; 120:3, s. 537-541
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background and purpose: To investigate the dose-response relation between the dose to the vagina and the patient-reported symptom absence of vaginal elasticity and how time to follow-up influences this relation. Material and methods: The study included 78 long-term gynecological cancer survivors treated between 1991 and 2003 with external beam radiation therapy. Of those, 24 experienced absence of vaginal elasticity. A normal tissue complication model is introduced that takes into account the influence of time to follow-up on the dose-response relation and the patients age. The best estimates of the dose-response parameters were calculated using Probit, Probit-Relative Seriality (RS) and Probit-time models. Log likelihood (LL) values and the Akaike Information Criterion (AIC) were used to evaluate the model fit. Results: The dose-response parameters for absence of vaginal elasticity according to the Probit and Probit-time models with the 68% Confidence Intervals (CI) were: LL = 39.8, D-50 = 49.7 (47.2-52.4) Gy, gamma(50) =1.40 (1.12-1.70) and LL = 37.4, D-50 = 46.9 (43.5-50.9) Gy, gamma(50) = 1.81 (1.17-2.51) respectively. Conclusions: The proposed model, which describes the influence of time to follow-up on the dose response relation, fits our data best. Our data indicate that the steepness of the dose-response curve of the dose to the vagina and the symptom absence of vaginal elasticity increases with time to follow-up, while D-50 decreases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.</p>
  •  
10.
  • Belin, Andrea Carmine, et al. (författare)
  • Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's disease.
  • 2007
  • Ingår i: Neuroscience letters. - 0304-3940. ; 420:3, s. 257-62
  • Tidskriftsartikel (refereegranskat)abstract
    • Mitochondrial (mt) dysfunction has been implicated in Alzheimer's (AD) and Parkinson's disease (PD). Mitochondrial transcription factor A (TFAM) is needed for mtDNA maintenance, regulating mtDNA copy number and is absolutely required for transcriptional initiation at mtDNA promoters. Two genetic variants in TFAM have been reported to be associated with AD in a Caucasian case-control material collected from Germany, Switzerland and Italy. One of these variants was reported to show a tendency for association with AD in a pooled Scottish and Swedish case-control material and the other variant was reported to be associated with AD in a recent meta-analysis. We investigated these two genetic variants, rs1937 and rs2306604, in an AD and a PD case-control material, both from Sweden and found significant genotypic as well as allelic association to marker rs2306604 in the AD case-control material (P=0.05 and P=0.03, respectively), where the A-allele appears to increase risk for developing AD. No association was observed for marker rs1937. We did not find any association in the PD case-control material for either of the two markers. The distribution of the two-locus haplotype frequencies (based on rs1937 and rs2306604) did not differ significantly between affected individuals and controls in the two sample sets. However, the global P-value for haplotypic association testing indicated borderline association in the AD sample set. Our data suggests that the rs2306604 A-allele could be a moderate risk factor for AD, which is supported by the recent meta-analysis.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (31)
Typ av publikation
tidskriftsartikel (224)
konferensbidrag (22)
doktorsavhandling (13)
rapport (9)
annan publikation (5)
bokkapitel (4)
visa fler...
bok (3)
visa färre...
Typ av innehåll
refereegranskat (237)
övrigt vetenskapligt (74)
populärvet., debatt m.m. (6)
Författare/redaktör
Lind, Lars, (85)
Lind, Bengt K, (39)
Sandblad, Bengt, (31)
Sennblad, Bengt, (30)
Strawbridge, Rona J. (30)
Hamsten, Anders (28)
visa fler...
Lind, Bengt (28)
Leander, Karin, (27)
Froguel, Philippe, (26)
de Faire, Ulf (26)
Jackson, Anne U. (26)
Collins, Francis S. (26)
Gigante, Bruna, (26)
Vessby, Bengt, (25)
Langenberg, Claudia (25)
Luan, Jian'an (25)
Mavroidis, Panayioti ... (24)
Kuusisto, Johanna, (24)
Laakso, Markku, (24)
Prokopenko, Inga (24)
Ingelsson, Erik (23)
Bergman, Richard N. (23)
Pedersen, Nancy L (22)
Scott, Robert A (22)
Salomaa, Veikko (22)
Chines, Peter S. (22)
Yengo, Loïc, (21)
Stancáková, Alena, (21)
Esko, Tonu (21)
Eriksson, Johan G. (21)
Metspalu, Andres (21)
Kanoni, Stavroula (21)
Lobbens, Stéphane, (20)
Lyssenko, Valeriya, (20)
Wareham, Nicholas J (20)
Boehnke, Michael (20)
Gustafsson, Stefan (20)
Stringham, Heather M ... (20)
Loos, Ruth J. F. (20)
Liu, Ching-Ti (20)
Mahajan, Anubha (20)
Bonnycastle, Lori L. (20)
McCarthy, Mark I (19)
Gieger, Christian (19)
Barroso, Inês (19)
Morris, Andrew P. (19)
Tuomilehto, Jaakko (19)
Lind, Bengt, 1948-, (19)
Morris, Andrew D (19)
Rauramaa, Rainer (19)
visa färre...
Lärosäte
Uppsala universitet (109)
Stockholms universitet (46)
Göteborgs universitet (30)
Lunds universitet (24)
Karolinska Institutet (21)
Kungliga Tekniska Högskolan (19)
visa fler...
Umeå universitet (17)
Linköpings universitet (16)
Högskolan i Jönköping (4)
Linnéuniversitetet (4)
Mälardalens högskola (3)
Högskolan Kristianstad (2)
Högskolan Väst (2)
Högskolan i Gävle (2)
Högskolan Dalarna (2)
Naturvårdsverket (1)
Mittuniversitetet (1)
Chalmers tekniska högskola (1)
visa färre...
Språk
Engelska (246)
Svenska (20)
Odefinierat språk (6)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (182)
Naturvetenskap (43)
Samhällsvetenskap (14)
Teknik (3)
Lantbruksvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy