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- Anderlind, Eva, et al.
(författare)
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Will haptic feedback speed up medical imaging? An application to radiation treatment planning
- 2008
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Ingår i: Acta Oncologica. - OSLO, Norge : Taylor & Francis. - 0284-186X .- 1651-226X. ; 47:1, s. 32-37
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Tidskriftsartikel (refereegranskat)abstract
- Haptic technology enables us to incorporate the sense of touch into computer applications, providing an additional input/output channel. The purpose of this study was to examine if haptic feedback can help physicians and other practitioners to interact with medical imaging and treatment planning systems. A haptic application for outlining target areas (a key task in radiation therapy treatment planning) was implemented and then evaluated via a controlled experiment with ten subjects. Even though the sample size was small, and the application only a prototype, results showed that haptic feedback can significantly increase (p0.05) the speed of outlining target volumes and organs at risk. No significant differences were found regarding precision or perceived usability. This promising result warrants further development of a full haptic application for this task. Improvements to the usability of the application as well as to the forces generated have been implemented and an experiment with more subjects is planned.
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- Aspholm-Hurtig, Marina, et al.
(författare)
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Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
- 2004
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5683, s. 519-22
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Tidskriftsartikel (refereegranskat)abstract
- Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.
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| 4. |
- Augusto, Ohara, et al.
(författare)
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Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research
- 2019
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Ingår i: Free Radical Biology & Medicine. - : ELSEVIER SCIENCE INC. - 0891-5849 .- 1873-4596. ; 135, s. 210-215
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Forskningsöversikt (refereegranskat)abstract
- Peroxynitrite, ONOO-, formed in tissues that are simultaneously generating NO center dot and O-2(center dot-), is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO2 via formation of an unstable adduct, ONOOC(O)O-, that undergoes O-O bond homolysis to produce NO2 center dot and CO3 center dot- radicals, whose yields are equal at about 0.33 with respect to the ONOO- reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these [Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31: 721-730; 2018] claims that ONOOC(O)O- is stable, predicts a yield of NO2 center dot/CO3 center dot- of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect.
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| 6. |
- Elmstedt, Nina, et al.
(författare)
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Temporal frequency requirements for tissue velocity imaging of the fetal heart
- 2011
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Ingår i: Ultrasound in Obstetrics and Gynecology. - : Wiley. - 0960-7692 .- 1469-0705. ; 38:4, s. 413-417
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Tidskriftsartikel (refereegranskat)abstract
- Objectives The high velocity and short duration of myocardial motion requires a high sampling rate to obtain adequate temporal resolution; this issue becomes even more important when taking into consideration the high fetal heart rate. In this study we have established optimal sampling requirements for assessing the duration of various cardiac cycle events and myocardial velocities of the fetal heart using color-coded tissue velocity imaging (TVI). Methods Recordings from 30 fetuses were acquired at an initial frame rate of 180-273 frames/s. All TVI recordings were performed from an apical four-chamber view and stored as cineloops of five to 10 consecutive cardiac cycles for subsequent offline analysis using software enabling a reduction in frame rate. Different components of the myocardial velocity curve, obtained from the basal part of the ventricular septum, were measured at the initial frame rate and compared with their equivalents at gradually decreased frame rates. Results As acquisition frame rate was reduced, there was a marked increase in deviation from the initial values, resulting in an underestimation of all systolic and diastolic velocities. For the measured durations, there was a clear tendency to underestimate isovolumetric contraction and relaxation, and a clear tendency to overestimate ventricular ejection and diastolic E-wave and A-wave. An acceptable <= 5% deviation from the value obtained at the highest frame rate corresponded to measurements obtained at above 150-200 frames/s. Conclusions A high sampling rate of at least 200 frames/s is necessary for adequate reconstruction of TVI data for the fetal heart. Frame rates that are too low result in considerable loss of temporal and velocity information.
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| 7. |
- Geschwind, Lars, 1970-, et al.
(författare)
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The Changing Roles of Academic Leaders : Decision-Making, Power, and Performance
- 2019. - 1
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Ingår i: Reforms, Organizational Change and Performance in Higher Education. - Cham : Palgrave Macmillan. - 9783030117382 - 9783030117375 ; , s. 181-210
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Bokkapitel (refereegranskat)abstract
- Major reforms in the Nordic countries have increased the formal autonomy of higher education institutions (HEIs) to make decisions over their own activities, both academic core tasks and managerial/administrative activities. The issue addressed in this chapter is how these changes have affected the role of the academic leader. Across the four countries, we see clear signs of change regarding academic leadership comprising a mix of institutional logics in the interviews: the professional, collegial traditional academic leadership, which is based on rotating systems, election among peers, and collegial decision-making, has been complemented with, and in some places replaced by, a managerial logic with top-down order-giving, performance measurement and appointed managers as a new academic profession. Another related general trend is the greater focus on individual managers. The analysis also shows that Denmark and Finland are the countries that lead the way when it comes to increasing the formal authority of managers. The introduction of appointed managers rather than elected ones has altered the way HEIs operate in these two countries. However, as this chapter has shed light on, management reform has not been implemented in the same depth and with the same pace across and within universities.
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| 10. |
- Pulkkinen, Kirsi, et al.
(författare)
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Does It Really Matter? Assessing the Performance Effects of Changes in Leadership and Management Structures in Nordic Higher Education
- 2019. - 1
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Ingår i: Reforms, Organizational Change and Performance in Higher Education<em></em>. - Cham : Palgrave Macmillan. ; , s. 3-36
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Bokkapitel (refereegranskat)abstract
- Universities are public organisations, which operate in a highly institutionalised environment. They are heavily dependent on public resources. As such, universities are susceptible to shifts in governance arrangements but are also far from being passive recipients of reform agendas. They face demands from multiple internal constituencies (academics, administrators, students, managers) and from a variety of external stakeholders. This chapter explores the interplay between governance arrangements resulting from policy shifts and university dynamics. It sets the stage for the book, asking the following research questions: (1) what characterises changes in governance regimes in Nordic universities in the last decade and a half, and (2) what effects have these changes had in the evolution of higher education systems? The chapter takes a comparative approach and identifies similarities and differences across the Nordic countries. This chapter serves as a frame of reference for the book and includes a common methods and data section.
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