SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lind Lars) srt2:(2015-2019);srt2:(2019);pers:(Magnusson Patrik K E)"

Sökning: WFRF:(Lind Lars) > (2015-2019) > (2019) > Magnusson Patrik K E

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Sundström, Johan, Professor, 1971-, et al. (författare)
  • Risk factors for subarachnoid haemorrhage : a nationwide cohort of 950 000 adults
  • 2019
  • Ingår i: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 48:6, s. 2018-2025
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Subarachnoid haemorrhage (SAH) is a devastating disease, with high mortality rate and substantial disability among survivors. Its causes are poorly understood. We aimed to investigate risk factors for SAH using a novel nationwide cohort consortium.METHODS: We obtained individual participant data of 949 683 persons (330 334 women) between 25 and 90 years old, with no history of SAH at baseline, from 21 population-based cohorts. Outcomes were obtained from the Swedish Patient and Causes of Death Registries.RESULTS: During 13 704 959 person-years of follow-up, 2659 cases of first-ever fatal or non-fatal SAH occurred, with an age-standardized incidence rate of 9.0 [95% confidence interval (CI) (7.4-10.6)/100 000 person-years] in men and 13.8 [(11.4-16.2)/100 000 person-years] in women. The incidence rate increased exponentially with higher age. In multivariable-adjusted Poisson models, marked sex interactions for current smoking and body mass index (BMI) were observed. Current smoking conferred a rate ratio (RR) of 2.24 (95% CI 1.95-2.57) in women and 1.62 (1.47-1.79) in men. One standard deviation higher BMI was associated with an RR of 0.86 (0.81-0.92) in women and 1.02 (0.96-1.08) in men. Higher blood pressure and lower education level were also associated with higher risk of SAH.CONCLUSIONS: The risk of SAH is 45% higher in women than in men, with substantial sex differences in risk factor strengths. In particular, a markedly stronger adverse effect of smoking in women may motivate targeted public health initiatives.
  •  
2.
  • Wuttke, Matthias, et al. (författare)
  • A catalog of genetic loci associated with kidney function from analyses of a million individuals
  • 2019
  • Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Lind, Lars (2)
Olsson, Håkan (1)
Andersson, Martin (1)
Engström, Gunnar (1)
Ärnlöv, Johan, 1970- (1)
Björck, Martin (1)
visa fler...
Janson, Christer (1)
Wanhainen, Anders (1)
Nilsson, Peter (1)
Salomaa, Veikko (1)
Perola, Markus (1)
Torén, Kjell, 1952 (1)
Olafsson, Isleifur (1)
Ingelsson, Martin (1)
Raitakari, Olli T (1)
Eriksson, Marie, Pro ... (1)
Forsberg, Bertil (1)
Melander, Olle (1)
Wolk, Alicja (1)
Brenner, Hermann (1)
Loeffler, Markus (1)
Ouwehand, Willem H. (1)
Soranzo, Nicole (1)
Rosengren, Annika, 1 ... (1)
Campbell, Harry (1)
Rudan, Igor (1)
Freedman, Barry I. (1)
Langefeld, Carl D. (1)
Jonas, Jost B. (1)
Marz, Winfried (1)
Lager, Anton (1)
Hallqvist, Johan, 19 ... (1)
Sundström, Johan, Pr ... (1)
Larsson, Susanna C. (1)
Schottker, Ben (1)
Alfredsson, Lars (1)
Almgren, Peter (1)
Kuusisto, Johanna (1)
Laakso, Markku (1)
Magnusson, Cecilia (1)
Järvholm, Bengt (1)
Ahluwalia, Tarunveer ... (1)
Schulz, Christina Al ... (1)
Orho-Melander, Marju (1)
Rossing, Peter (1)
Ridker, Paul M. (1)
Chasman, Daniel I. (1)
Demirkan, Ayse (1)
Ikram, M. Arfan (1)
Amin, Najaf (1)
visa färre...
Lärosäte
Uppsala universitet (2)
Lunds universitet (2)
Karolinska Institutet (2)
Göteborgs universitet (1)
Umeå universitet (1)
Jönköping University (1)
visa fler...
Mittuniversitetet (1)
Högskolan Dalarna (1)
visa färre...
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
År
2019 (2)Ta bort avgränsningen

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy