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Left ventricular re...
Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention
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- Andersson, Jonas (author)
- Umeå universitet,Medicin
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- Mellberg, Caroline (author)
- Umeå universitet,Medicin
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- Otten, Julia (author)
- Umeå universitet,Medicin
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- Ryberg, Mats (author)
- Umeå universitet,Medicin
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- Rinnström, Daniel (author)
- Umeå universitet,Kardiologi
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- Larsson, Christel, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science
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- Lindahl, Bernt (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Hauksson, Jon (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,d Department of Radiography and Biomedical Science, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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- Johansson, Bengt (author)
- Umeå universitet,Kardiologi
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- Olsson, Tommy (author)
- Umeå universitet,Medicin
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 216, s. 92-96
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women. Methods: Sixty-eight healthy postmenopausal women with body mass index [BMI] >= 27 kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24 months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24 months. Results: Despite mean weight losses of 4.9 (1.0) kg (NNR) and 7.8 (1.1) kg (PD), the MTG content did not change over time (p = 0.98 in the NNR and p = 0.11 in the PD group at 24 months). Reduced left ventricular mass was observed in both diet groups over 24 months. Blood pressure was reduced at 6 months, but returned to baseline levels at 24 months. End diastolic volume, stroke volume, and cardiac output decreased over time. No differences between diet groups were observed. Conclusions: Diet intervention and moderate weight loss over 24 months improved LV remodelling but did not alter MTG levels in overweight/obese postmenopausal women. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Cardiac Magnetic Resonance (CMR) imaging
- Diet
- Metabolic heart disease
- Obesity
- Weight reduction
- obese postmenopausal women
- paleolithic-type diet
- triglyceride content
- resonance-spectroscopy
- caloric restriction
- diabetes-mellitus
- bariatric surgery
- weight-loss
- heart
- steatosis
- Cardiovascular System & Cardiology
- Cardiac Magnetic Resonance (CMR) imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Andersson, Jonas
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Mellberg, Caroli ...
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Otten, Julia
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Ryberg, Mats
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Rinnström, Danie ...
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Larsson, Christe ...
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Lindahl, Bernt
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Hauksson, Jon
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Johansson, Bengt
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Olsson, Tommy
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg
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Umeå University