SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Lindblad Per 1953 )
 

Sökning: WFRF:(Lindblad Per 1953 ) > Forsti A > VHL down-regulation...

VHL down-regulation and differential localization as mechanisms in tumorigenesis

Shiao, Y. H. (författare)
Forsti, A. (författare)
Egevad, L. (författare)
Karolinska Institutet
visa fler...
Anderson, L. M. (författare)
Lindblad, Per, 1953- (författare)
Hemminki, K. (författare)
visa färre...
 (creator_code:org_t)
Malden, USA : Blackwell Publishing, 2003
2003
Engelska.
Ingår i: Kidney International. - Malden, USA : Blackwell Publishing. - 0085-2538 .- 1523-1755. ; 64:5, s. 1671-1674
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: The von Hippel-Lindau (VHL) gene has been widely analyzed in many tumors. Early studies in animal tumors suggest that changes in VHL protein level and localization may be also important in tumorigenesis. In this study, we determined the role of VHL protein in human renal cell carcinomas. METHODS: Seventy-five human renal cell carcinomas, predominantly of clear cell type (60 of 75), were examined for VHL protein by immunohistochemistry. The level and pattern of protein expression were then compared to VHL mutations and tumor characteristics.Results: An apparent decline of VHL level (positive in <50% of tumor cells) was observed in 49 (65%) tumors, a change more frequent than VHL mutations (28 of 75) (37%). In tumors, VHL was localized to the cytoplasm and/or the cell membrane. The occurrence of a predominantly membranous signal was significantly associated with missense mutations (9 of 14 tumors with missense mutations versus 14 of 61 tumors with no or nonmissense mutations, P = 0.0025) and tumor stage (23 of 60 tumors with stage TI versus 0 of 15 tumors with TII and TIII, P = 0.0034).Conclusion: This study provides the first evidence of the role of VHL protein level and intracellular localization in tumorigenesis in humans.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Antibodies
Carcinoma
Renal Cell/*metabolism/pathology
Down-Regulation
Genotype
Humans
Kidney Neoplasms/*metabolism/pathology
*Mutation
Missense
Neoplasm Staging
Phenotype
Tumor Suppressor Proteins/*genetics/immunology/*metabolism
Ubiquitin-Protein Ligases/*genetics/immunology/*metabolism
Von Hippel-Lindau Tumor Suppressor Protein

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy