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Temporal trends of ...
Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
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- Lindehammer, Sabina (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Dept. of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
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- Larsson, Karin (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Pediatrics, Kristianstad Hospital, Kristianstad, Sweden
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- Örtqvist, E. (author)
- Karolinska Institutet
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- Carlsson, Annelie (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Dept. of Pediatrics, Malmö, Sweden,Department of Clinical Sciences, Unit of Pediatrics, University Hospital, Lund University, Malmö, Sweden
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- Cederwall, E. (author)
- Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden,Dept. of Pediatrics, Karlskrona, Sweden
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- Cilio, Corrado (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Dept. of Pediatrics, Jönköping, Sweden,Department of Clinical Sciences, Cellular Autoimmunity Unit, University Hospital, Lund University, Malmö, Sweden
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- Sjöblad, Sture (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Dept. of Pediatrics, Lund, Sweden,Department of Clinical Sciences, Unit of Pediatrics, University Hospital, Lund University, Malmö, Sweden
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- Jönsson, B. A. (author)
- Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden,Dept. of Pediatrics, Örebro, Sweden
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- Larsson, Helena (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Clinical Sciences, Unit of Pediatrics, University Hospital, Lund University, Malmö, Sweden
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- Lynch, Kristian (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
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- Neiderud, Jan (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Dept. of Pediatrics, Helsingborg, Sweden,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
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- Nilsson, Anna (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
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Sjöblad, S. (author)
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden; Department of Medicine, University of Washington, Seattle, WA, USA
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- Aili, M. (author)
- Dept. of Pediatrics, Halmstad, Sweden
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- Bååth, L. E. (author)
- Dept. of Pediatrics, Östersund, Sweden,Dept. of Pediatrics, Mölndal, Sweden
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- Carlsson, E. (author)
- Dept. of Pediatrics, Kalmar, Sweden
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- Edenwall, H. (author)
- Dept. of Pediatrics, Karlskrona, Sweden,Dept. of Pediatrics, Umeå, Sweden
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- Forsander, Gun, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Granstro, B. W. (author)
- Dept. of Pediatrics, Gällivare, Sweden
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- Gustavsson, I. (author)
- Dept. of Pediatrics, Skellefteå, Sweden
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- Hanås, R. (author)
- Dept. of Pediatrics, Uddevalla, Sweden
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- Hellenberg, L. (author)
- Dept. of Pediatrics, Nyköping, Sweden
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- Hellgren, H. (author)
- Dept. of Pediatrics, Lidköping, Sweden,Dept. of Pediatrics, Hudiksvall, Sweden
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- Holmberg, E. (author)
- Dept. of Pediatrics, Umeå, Sweden
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- Hörnell, H. (author)
- Dept. of Pediatrics, Hudiksvall, Sweden
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- Ivarsson, Sten-A. (author)
- Dept. of Pediatrics, Malmö, Sweden
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- Johansson, C. (author)
- Dept. of Pediatrics, Jönköping, Sweden
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- Jonsell, G. (author)
- Dept. of Pediatrics, Karlstad, Sweden
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- Kockum, K. (author)
- Dept. of Pediatrics, Ystad, Sweden,Dept. of Pediatrics, Skilstuna, Sweden,Dept. of Pediatrics, Danderyd, Sweden
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- Lindblad, Birgitta Ejdervik, 1955- (author)
- Dept. of Pediatrics, Mölndal, Sweden,Swedish Childhood Diabetes Study Group
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- Lindh, A. (author)
- Dept. of Pediatrics, Borås, Sweden
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- Ludvigsson, Jonas F., 1969- (author)
- Dept. of Pediatrics, Linköping, Sweden,Swedish Childhood Diabetes Study Group
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- Myrdal, U. (author)
- Dept. of Pediatrics, Västerås, Sweden
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- Neiderud, J. (author)
- Dept. of Pediatrics, Helsingborg, Sweden
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- Segnestam, K. (author)
- Dept. of Pediatrics, Skilstuna, Sweden
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- Sjöblad, S. (author)
- Dept. of Pediatrics, Lund, Sweden
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- Skogsberg, L. (author)
- Dept. of Pediatrics, Boden, Sweden
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- Strömberg, L. (author)
- Dept. of Pediatrics, Norrköping, Sweden
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- Ståhle, U. (author)
- Dept. of Pediatrics, Ängelholm, Sweden
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- Thalme, B. (author)
- Dept. of Pediatrics, Huddinge, Sweden
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- Tullus, K. (author)
- Dept. of Pediatrics, Danderyd, Sweden
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- Tuvemo, Torsten (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson
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- Wallensteen, M. (author)
- Dept. of Pediatrics, Stockholm, Sweden
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- Westphal, Otto, 1935 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Åman, Jan, 1948- (author)
- Örebro universitet,Hälsoakademin,Swedish Childhood Diabetes Study Group
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- Lindblad, Bengt (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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(creator_code:org_t)
- 2008-09-04
- 2008
- English.
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In: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-5
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- HLA-DQ
- Genotype
- Temporal trends
- Age at diagnosis
- Autoimmune disease
- MEDICINE
- MEDICIN
- Internal medicine
- Diabetology
- Invärtesmedicin
- HLA-DQ
- Genotype
- Temporal trends
- Age at diagnosis
- Autoimmune disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lindehammer, Sab ...
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Larsson, Karin
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Örtqvist, E.
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Carlsson, Anneli ...
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Cederwall, E.
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Cilio, Corrado
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show more...
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Sjöblad, Sture
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Jönsson, B. A.
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Larsson, Helena
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Lynch, Kristian
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Neiderud, Jan
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Nilsson, Anna
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Sjöblad, S.
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Lernmark, Åke
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Aili, M.
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Bååth, L. E.
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Carlsson, E.
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Edenwall, H.
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Forsander, Gun, ...
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Granstro, B. W.
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Gustavsson, I.
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Hanås, R.
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Hellenberg, L.
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Hellgren, H.
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Holmberg, E.
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Hörnell, H.
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Ivarsson, Sten-A ...
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Johansson, C.
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Jonsell, G.
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Kockum, K.
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Lindblad, Birgit ...
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Lindh, A.
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Ludvigsson, Jona ...
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Myrdal, U.
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Neiderud, J.
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Segnestam, K.
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Skogsberg, L.
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Strömberg, L.
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Ståhle, U.
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Thalme, B.
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Tullus, K.
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Tuvemo, Torsten
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Wallensteen, M.
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Westphal, Otto, ...
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Åman, Jan, 1948-
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Lindblad, Bengt
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Acta Diabetologi ...
- By the university
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Uppsala University
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Örebro University
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Lund University
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Linköping University
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Karolinska Institutet
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University of Gothenburg