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Sökning: WFRF:(Linder Stig) > Sveriges Lantbruksuniversitet

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1.
  • Fryknäs, Mårten, et al. (författare)
  • Iron chelators target both proliferating and quiescent cancer cells
  • 2016
  • Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • Poorly vascularized areas of solid tumors contain quiescent cell populations that are resistant to cell cycle-active cancer drugs. The compound VLX600 was recently identified to target quiescent tumor cells and to inhibit mitochondrial respiration. We here performed gene expression analysis in order to characterize the cellular response to VLX600. The compound-specific signature of VLX600 revealed a striking similarity to signatures generated by compounds known to chelate iron. Validation experiments including addition of ferrous and ferric iron in excess, EXAFS measurements, and structure activity relationship analyses showed that VLX600 chelates iron and supported the hypothesis that the biological effects of this compound is due to iron chelation. Compounds that chelate iron possess anti-cancer activity, an effect largely attributed to inhibition of ribonucleotide reductase in proliferating cells. Here we show that iron chelators decrease mitochondrial energy production, an effect poorly tolerated by metabolically stressed tumor cells. These pleiotropic features make iron chelators an attractive option for the treatment of solid tumors containing heterogeneous populations of proliferating and quiescent cells.
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2.
  • Nordin, Annika, et al. (författare)
  • Science for trade-offs between conflicting interests in future forests
  • 2011
  • Ingår i: Forests. - : MDPI. - 1999-4907 .- 1999-4907. ; 2:3, s. 631-636
  • Tidskriftsartikel (refereegranskat)abstract
    • Forests deliver multiple ecosystem services to society. Management of forests must be able to deal with trade-offs when the delivery of different ecosystem services comes in conflict with each other. The research program Future Forests (http://www.futureforests.se) attempts to form a scientific basis for managing such trade-offs between conflicting interests in northern boreal forests. Some key characteristics of the research program are interdisciplinary and participatory research and a clear communication agenda for stakeholders. This paper gives a brief overview of the underlying ideas behind the program, and an introduction to the papers published in this Special Issue.
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