| 1. |
- Eriksson, Ove, et al.
(författare)
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Historical Ecology of Scandinavian Infield Systems
- 2021
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 13:2
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Tidskriftsartikel (refereegranskat)abstract
- Infield systems originated during the early Iron Age and existed until the 19th century, although passing many transitions and changes. The core features of infield systems were enclosed infields with hay-meadows and crop fields, and unenclosed outland mainly used for livestock grazing. We examine the transitions and changes of domesticated landscapes with infield systems using the framework of human niche construction, focusing on reciprocal causation affecting change in both culture and environment. A first major transition occurred during the early Middle Ages, as a combined effect of a growing elite society and an increased availability of iron promoted expansion of villages with partly communal infields. A second major transition occurred during the 18th and 19th centuries, due to a then recognized inefficiency of agricultural production, leading to land reforms. In outlands, there was a continuous expansion of management throughout the whole period. Even though external factors had significant impacts as well, human niche construction affected a range of cultural and environmental features regarding the management and structure of domesticated landscapes with infield systems. Thus, niche construction theory is a useful framework for understanding the historical ecology of infield systems.
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| 2. |
- Gaulton, Kyle J, et al.
(författare)
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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
- 2015
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:12, s. 1415-1415
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Tidskriftsartikel (refereegranskat)abstract
- We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
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| 3. |
- Lindholm, Mathias, et al.
(författare)
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Local bias adjustment, duration-weighted probabilities, and automatic construction of tariff cells
- 2023
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Ingår i: Scandinavian Actuarial Journal. - : Informa UK Limited. - 0346-1238 .- 1651-2030. ; 2023:10, s. 946-973
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Tidskriftsartikel (refereegranskat)abstract
- We study non-life insurance pricing and present a general procedure for constructing a distribution-free locally unbiased predictor of the risk premium based on any initially suggested predictor. The resulting predictor is piecewise constant, corresponding to a partition of the covariate space, and by construction auto-calibrated. Two key issues are the appropriate partitioning of the covariate space and the handling of randomly varying durations, acknowledging possible early termination of contracts. A basic idea in the present paper is to partition the predictions from the initial predictor, which as a by-product defines a partition of the covariate space. Two different approaches to create partitions are discussed in detail using (i) duration-weighted equal-probability binning, and (ii) binning by duration-weighted regression trees. Given a partitioning procedure, the size of the partition to be used is obtained using cross-validation. In this way we obtain an automatic data-driven tariffication procedure, where the number of tariff cells corresponds to the size of the partition. We illustrate the procedure based on both simulated and real insurance data, using both simple GLMs and GBMs as initial predictors. The resulting tariffs are shown to have a rather small number of tariff cells while maintaining or improving the predictive performance compared to the initial predictors.
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| 4. |
- Lindskog, Cecilia, et al.
(författare)
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The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling
- 2015
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- Background: To understand cardiac and skeletal muscle function, it is important to define and explore their molecular constituents and also to identify similarities and differences in the gene expression in these two different striated muscle tissues. Here, we have investigated the genes and proteins with elevated expression in cardiac and skeletal muscle in relation to all other major human tissues and organs using a global transcriptomics analysis complemented with antibody-based profiling to localize the corresponding proteins on a single cell level. Results: Our study identified a comprehensive list of genes expressed in cardiac and skeletal muscle. The genes with elevated expression were further stratified according to their global expression pattern across the human body as well as their precise localization in the muscle tissues. The functions of the proteins encoded by the elevated genes are well in line with the physiological functions of cardiac and skeletal muscle, such as contraction, ion transport, regulation of membrane potential and actomyosin structure organization. A large fraction of the transcripts in both cardiac and skeletal muscle correspond to mitochondrial proteins involved in energy metabolism, which demonstrates the extreme specialization of these muscle tissues to provide energy for contraction. Conclusions: Our results provide a comprehensive list of genes and proteins elevated in striated muscles. A number of proteins not previously characterized in cardiac and skeletal muscle were identified and localized to specific cellular subcompartments. These proteins represent an interesting starting point for further functional analysis of their role in muscle biology and disease.
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| 5. |
- Linell, Per, et al.
(författare)
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Multi-unit questions in institutional interactions : Sequential organizations and communicative functions
- 2003
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Ingår i: Text. ; 23:4, s. 539-571
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Tidskriftsartikel (refereegranskat)abstract
- This article deals with multi-unit questioning turns used in different genres of institutional interactions. Analyzing in detail a corpus of about 400 multiunit questions from health care interactions, court trials, police interrogations, and social welfare office talks from Sweden and Finland (all in the Swedish language), a number of sequential patterns are established. Some of these sequential organizations revolve around the interplay between declarative and interrogative units. Several interrogatives in a series usually narrow down questions, for example, by suggesting candidate answers to the initial more general questions. However, many multi-unit questioning turns are concluded with an appended generalizing question. The communicative functions of these different question delivery structures are summarized. We argue that the theory must be sensitive to differences between communicative activity types. However, on the general level, we propose that designing a multi-unit question is an attempt at solving a complex communicative task, which typically involves several, possibly mutually conflicting, demands on the speaker. For example, in court trials, the avoidance of leading questions must be balanced against the need for precise answers. At the same time, the use of an appended generalizing unit might be formulated to secure anything that could count as an acceptable response.
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