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Sökning: WFRF:(Lindholt Jes) > Uppsala universitet

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  • Bergqvist, David, et al. (författare)
  • Antimicrobial treatment to impair expansion of abdominal aortic aneurysm (AAA) : a systematic review of the clinical evidence
  • 2013
  • Ingår i: Current vascular pharmacology. - : Bentham Science Publishers Ltd.. - 1875-6212 .- 1570-1611. ; 11:3, s. 288-292
  • Forskningsöversikt (refereegranskat)abstract
    • Antimicrobial treatment to attenuate expansion of abdominal aortic aneurysm has been suggested, especially with the focus on Chlamydophila. In this systematic literature review only four randomized trials were identified. In two small studies there is an indication of an effect of roxithromycin. In conclusion, however, more studies are needed, and they must be properly sized based on power calculations as well as antimicrobially relevant. Such trials are on the way both in Europe and the US, the results being awaited with interest.
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  • Jones, Gregory T., et al. (författare)
  • Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
  • 2017
  • Ingår i: Circulation Research. - 0009-7330 .- 1524-4571. ; 120:2, s. 341-
  • Tidskriftsartikel (refereegranskat)abstract
    • Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies. Methods and Results: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. Conclusions: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
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  • Resultat 1-10 av 11
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tidskriftsartikel (9)
forskningsöversikt (2)
Typ av innehåll
refereegranskat (11)
Författare/redaktör
De Borst, Gert J (9)
Lindholt, Jes S (9)
Chakfé, Nabil (8)
Björck, Martin (7)
Wanhainen, Anders (7)
Kolh, Philippe (7)
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Kakkos, Stavros K. (7)
Tulamo, Riikka (7)
Vermassen, Frank (6)
Twine, Christopher P (5)
Dias, Nuno V. (4)
Dick, Florian (4)
Coscas, Raphaël (4)
Trimarchi, Santi (4)
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Ricco, Jean-Baptiste (3)
Mani, Kevin, 1975- (3)
de Ceniga, Melina Ve ... (3)
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van den Berg, Jos C. (3)
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Cohnert, Tina (2)
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Debus, Sebastian (2)
Venermo, Maarit (2)
Kakkos, Stavros (2)
Lindholt, Jes (2)
Antoniou, George A. (2)
Mees, Barend M.E. (2)
Szeberin, Zoltan (2)
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Uppsala universitet  (11)Ta bort avgränsningen
Umeå universitet (3)
Lunds universitet (2)
Karolinska Institutet (2)
Göteborgs universitet (1)
Örebro universitet (1)
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