| 1. |
- Cao, Hao, 1988-, et al.
(författare)
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Developmental bisphenol A diglycidyl ether (BADGE) exposure causes cell over-proliferation in Drosophila
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Since the estrogenic activity of bisphenol A had been reported, the industry started to find a proper replacement. Bisphenol A diglycidyl ether (BADGE) is one of the derivatives of BPA which is used widely in epoxy resin manufactory. Recently, some studies have demonstrated the adverse effects of BADGE on reproduction and development. However, the knowledge of BADGE is still scarce. Because of its hydrolytic property, BADGE is usually detected at a low level in commodities and the influences seem to be underestimated. In our study, we use the whole transcriptome sequencing to assess the effects of developmental BADGE exposure on Drosophila melanogaster. Notably, the genes related to cell proliferation are significantly affected by BADGE exposure. More detailed, a group of mitotic genes, including string (stg, human CDC25A), Cyclin B (CycB, human CCNB1), Cyclin E (CycE, human CCNE1), and pan gu (png, human NEK11), are detectable overexpressed. Phenotypically, we observe that BADGE induces severe hemocytes over-proliferation in the 3rd instar larvae, but does not cause morphological damage of the larval lymph gland and blood circulation. In conclusion, we provide evidence to show the carcinogenic potential of BADGE and raise the concern of better understanding of xenobiotics.
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| 2. |
- Hermansson, Ruth S., et al.
(författare)
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Incidence of oncogenic HPV and HPV-related dysplasia five years after a negative HPV test by self-sampling in elderly women
- 2022
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Ingår i: Infectious Agents and Cancer. - : Springer Nature. - 1750-9378. ; 17:42
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Cervical cancer prevention for older women can be challenging since there are no specific guidelines for this group. This study aimed to determine the incidence of oncogenic HPV and HPV-related dysplasia in elderly women 5 years after being HPV negative.Methods: Invited women participated five years earlier in a study where self-sampling for HPV testing was applied, at this time, they were all HPV negative. The women were now, five years later invited to perform self-sampling for HPV testing. Women with a positive result performed a repeat HPV test. Those with a positive repeat HPV test were examined by colposcopy, biopsy and cytology.Results: Of the 804 invited women, 634 (76.9%) agreed to participate in the study and a self-sampling kit was sent to them. Of these, 99.6% (632/634) sent a sample to the HPV laboratory. The participation rate in each age group was 93.3% at age 65, 74.0% at age 70, 80.7% at age 75 and 64.6% at age 80. Overall 18 women (2.8%, 95% CI 3.2 to 6.0) were HPV positive in the first test and 8 (1.3%, 95% CI 0.6 to 2.6) in the second test. Sampling for the second test was done on average 5.4 months after the first test. Fifty per cent (4/8) of the women with a positive repeat test had dysplasia in histology.Conclusions: The incidence of HPV in previously HPV-negative elderly women was low. Among women who were HPV positive in a repeat test, there was a high prevalence of low grade dysplasia.
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| 3. |
- Vik, Hanne Hagtvedt, et al.
(författare)
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Histories of Human Rights in the Nordic Countries
- 2018
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Ingår i: Nordic Journal of Human Rights. - : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. - 1891-8131 .- 1891-814X. ; 36:3, s. 189-201
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Tidskriftsartikel (refereegranskat)abstract
- Do the Nordics warrant the label 'global good Samaritans' in human rights promotion? Is the Nordic welfare state a close to perfect realisation of human rights norms? Alternatively, do Nordic international and domestic human rights policies constitute a peculiar 'Nordic human rights paradox' where norms are supported internationally while not being implemented at home? In what is the first collection of articles on Nordic human rights history, we take issue with previous scholarship, finding it often to be unsubstantiated and lacking a basis in historical contexts and relevant source materials. This also includes the stream of historical studies in the past decade, where, until recently, the Nordic countries have represented something of a blind spot. However, the lack of prior interest in the region means there are several promising avenues for historical investigations of both the Nordic countries in human rights history and the role of human rights in the history of the region.
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| 4. |
- Williams, Michael J., et al.
(författare)
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Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila
- 2020
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Ingår i: Environmental Science and Pollution Research. - : SPRINGER HEIDELBERG. - 0944-1344 .- 1614-7499. ; 27:20, s. 25261-25270
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Tidskriftsartikel (refereegranskat)abstract
- Bisphenol A diglycidyl ether (BADGE), a derivative of bisphenol A (BPA), is widely used in the manufacture of epoxy resins as well as a coating on food containers. Recent studies have demonstrated the adverse effects of BADGE on reproduction and development in rodents and amphibians, but how BADGE affects biological activity is not understood. To gain a better understanding of the biological effects of BADGE exposure during development, we used the model organism Drosophila melanogaster and performed whole transcriptome sequencing. Interestingly, when Drosophila are raised on food containing BADGE, genes having significantly increased transcript numbers are enriched for those involved in regulating cell proliferation, including DNA replication and cell cycle control. Furthermore, raising larvae on BADGE-containing food induces hemocyte (blood cell) over-proliferation. This effect can be stimulated with even lower concentrations of BADGE if the hemocytes are already primed for cell proliferation by the expression of dominant active Ras GTPase. We conclude that chronic exposure to the xenobiotic BADGE throughout development can induce cell proliferation.
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