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Reduced CSF CART in...
Reduced CSF CART in dementia with Lewy bodies.
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- Schultz, Kristofer (author)
- Lund University,Lunds universitet,Translationell neuroendokrinologi,Forskargrupper vid Lunds universitet,Translational Neuroendocrinology,Lund University Research Groups
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- Wiehager, Sara (author)
- Lund University,Lunds universitet,Translationell neuroendokrinologi,Forskargrupper vid Lunds universitet,Translational Neuroendocrinology,Lund University Research Groups
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- Nilsson, Karin (author)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Nielsen, Jørgen E (author)
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Lindquist, Suzanne G (author)
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Hjermind, Lena E (author)
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Andersen, Birgitte B (author)
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- Wallin, Anders, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Nilsson, Christer (author)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Petersén, Åsa (author)
- Lund University,Lunds universitet,Translationell neuroendokrinologi,Forskargrupper vid Lunds universitet,Translational Neuroendocrinology,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Neuroscience letters. - : Elsevier BV. - 0304-3940. ; 453:2, s. 104-6
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Abstract
Subject headings
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- Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Aged
- Alzheimer Disease
- cerebrospinal fluid
- diagnosis
- Amyloid beta-Protein
- cerebrospinal fluid
- Analysis of Variance
- Female
- Humans
- Lewy Body Disease
- cerebrospinal fluid
- diagnosis
- Male
- Nerve Tissue Proteins
- cerebrospinal fluid
- Peptide Fragments
- cerebrospinal fluid
- Radioimmunoassay
- tau Proteins
- cerebrospinal fluid
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schultz, Kristof ...
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Wiehager, Sara
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Nilsson, Karin
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Nielsen, Jørgen ...
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Lindquist, Suzan ...
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Hjermind, Lena E
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Andersen, Birgit ...
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Wallin, Anders, ...
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Nilsson, Christe ...
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Petersén, Åsa
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuroscience let ...
- By the university
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University of Gothenburg
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Lund University