| 1. |
- Teigland, Robin, et al.
(författare)
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Investigating the Uppsala Biotech Cluster : Baseline Results from the 2004 Uppsala Biotech Cluster Survey
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Just 65 kilometers to the north of Stockholm, Sweden, the Uppsala region has beenincreasingly receiving worldwide recognition during the past five years as a strongand dynamic cluster in the field of biotechnology. In 2003, Vinnova and theVinnväxt Program awarded Uppsala BIO – the Life Science Initiative a package offinancial support for a period of ten years to further support the region’sdevelopment and competitiveness. Uppsala BIO contracted CIND to facilitate inthis process, and one of CIND’s first activities was to conduct the 2004 UppsalaBiotech Cluster Survey. This survey was designed to gain an understanding of thecurrent “state of affairs” in the Uppsala biotech cluster, and selected survey resultsare presented in this report.
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| 2. |
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| 3. |
- Forslund, Anders, et al.
(författare)
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Flykting- och anhöriginvandrades etablering på den svenska arbetsmarknaden, IFAU Rapport 2017:14
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Vi beskriver arbetsmarknadsetablering och integration i Sverige på kort och lång sikt för invandrare från länder utanför västvärlden. Analysen omfattar huvudsakligen flykting- och anhöriginvandring under perioden 1990–2014. Mönstren för första kontakter med och etablering på arbetsmarknaden varierar med konjunkturläget, ursprungsland och med andra bakgrundsfaktorer. Men det huvudsakliga budskapet är att inträdesprocessen är långsam och att sysselsättning och inkomster av arbete även på lång sikt är lägre för invandrade relativt genomsnittet i arbetskraften i stort. Mönstren är på sikt påtagligt stabila för personer som kommit under olika tidsperioder och förutsättningar. Antalet jobb före det ”första riktiga” arbetsmarknadsinträdet är begränsat, och den första arbetsgivarkontakten är för många en väg till en mer stabil anställning. De första jobben återfinns jämförelsevis ofta i små låglöneföretag, som över tid koncentrerats mer till tjänstesektorn. Vi diskuterar också tänkbara effekter av olika politiska reformer och insatser.
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| 4. |
- Lindqvist, Johan, 1985-
(författare)
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Cellular and Molecular Mechanisms Underlying Congenital Myopathy-related Weakness
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Congenital myopathies are a rare and heterogeneous group of diseases. They are primarily characterised by skeletal muscle weakness and disease-specific pathological features. They harshly limit ordinary life and in severe cases, these myopathies are associated with early death of the affected individuals. The congenital myopathies investigated in this thesis are nemaline myopathy and myofibrillar myopathy. These diseases are usually caused by missense mutations in genes encoding myofibrillar proteins, but the exact mechanisms by which the point mutations in these proteins cause the overall weakness remain mysterious. Hence, in this thesis two different nemaline myopathy-causing actin mutations and one myofibrillar myopathy-causing myosin-mutation found in both human patients and mouse models were used to investigate the cascades of molecular and cellular events leading to weakness.I performed a broad range of functional and structural experiments including skinned muscle fibre mechanics, small-angle X-ray scattering as well as immunoblotting and histochemical techniques. Interestingly, according to my results, point mutations in myosin and actin differently modify myosin binding to actin, cross-bridge formation and muscle fibre force production revealing divergent mechanisms, that is, gain versus loss of function (papers I, II and IV). In addition, one point mutation in actin appears to have muscle-specific effects. The presence of that mutant protein in respiratory muscles, i.e. diaphragm, has indeed more damaging consequences on myofibrillar structure than in limb muscles complexifying the pathophysiological mechanisms (paper II).As numerous atrophic muscle fibres can be seen in congenital myopathies, I also considered this phenomenon as a contributing factor to weakness and characterised the underlying causes in presence of one actin mutation. My results highlighted a direct muscle-specific up-regulation of the ubiquitin-proteasome system (paper III).All together, my research work demonstrates that mutation- and muscle-specific mechanisms trigger the muscle weakness in congenital myopathies. This gives important insights into the pathophysiology of congenital myopathies and will undoubtedly help in designing future therapies.
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| 5. |
- Lindqvist, Janne, 1969-, et al.
(författare)
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Temaintroduktion: Aristoteles Retoriken
- 2014
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Ingår i: Rhetorica Scandinavica. - 1397-0534 .- 2002-7974. ; :68, s. 6-7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Lindqvist, Niclas
(författare)
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Neurotrophic Factor Receptors in the Normal and Injured Visual System : Focus on Retinal Ganglion Cells
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons.With the intention to gain knowledge about systems that can be used to decrease RGC death after ONT, we have studied growth factor receptors belonging to the tyrosine kinase family of receptors (RTK), known to mediate important cell survival signals. We found that the RTK Ret and its coreceptor GFRα1 were expressed by RGCs, and to test the above-mentioned hypothesis, we intraocularly administered glial cell-line derived factor, which activates a Ret-GFRα1 complex, and found transiently mediated RGC survival after ONT.To identify new, potential neurotrophic factor receptors expressed by RGCs, with the aim to improve RGC survival after ONT, we developed a method for the molecular analysis of acutely isolated RGCs. The method involves retrograde neuronal tracing, mechanical retinal layer-separation, and isolation of individual RGCs under UV-light for RT-PCR analysis. Using this method, in combination with degenerate PCR directed towards the tyrosine kinase domain, several RTKs were identified. Axl, Sky, VEGFR-2, VEGFR-3, CSF-1R, and PDGF-βR are expressed by adult RGCs, and considered to be receptors with potential neurotrophic activity. Other results have shown that RGCs may require depolarization or increase in intracellular cAMP levels in order to fully respond to exogenously added trophic factors. We found that melanocortin receptors (MCRs) were expressed by RGCs, and MCRs can mediate elevation of intracellular AMP. We observed that α-MSH induced neurite outgrowth from embryonic retinal cells, indicating that MCR ligands have direct effects on retinal cells. RTKs and their ligands may be involved in endogenous systems for neuronal repair within the visual system. BDNF, NT-3, FGF2, and HGFR all increased in the retina after ONT and may be a part of an activated system for neuronal repair locally within the retina.Adult axotomized RGCs die by apoptosis, therefore we examined the regulation of apoptotic genes after ONT. Bim and Bax increased in the retina after ONT, and may promote death of axotomized RGCs, whereas the increase in Bcl-2 may contribute to limit RGC apoptosis after ONT.All in all, this thesis provides insights into the expression and regulation of molecules involved in the death and survival of RGCs. The results have revealed a number of potential neurotrophic receptors expressed by RGCs, and both identified RTKs and MCRs will serve as new targets in therapeutic approaches aiming at counteraction of RGC death after injury.
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| 9. |
- Lindqvist, Ulla, et al.
(författare)
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[11C]Hyaluronan uptake with positron emission tomography in liver disease
- 2000
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Ingår i: European Journal of Clinical Investigation. - : Wiley. - 0014-2972 .- 1365-2362. ; 30:7, s. 600-607
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundA hyaluronan-loading test has been developed for assessment of hyaluronan kinetics and applied in patients with liver and joint diseases. This test describes the metabolic process of hyaluronan but cannot define the specific contribution of different organs. A method for labelling of hyaluronan with the short-lived positron-emitting radionuclide 11C has been published and in this study applied in healthy subjects and liver diseases.Materials and methodsPositron emission tomography (PET) was used for the regional assessment and quantification of [11C]hyaluronan uptake in three healthy subjects, four patients with alcoholic liver cirrhosis, one with alcoholic hepatitis and one with liver steatosis. After intravenous administration of 60 MBq of 11C-labelled hyaluronan, a 55-min PET scan was performed over the liver and plasma radioactivity was analysed. Rate constants describing the transport of the [11C]hyaluronan tracer from plasma to the liver were calculated.ResultsHigh uptake was observed in the liver combined with a rapid elimination of tracer from plasma. The liver uptake rate (k1) was significantly lower in patients (0.018 min−1) than in healthy subjects (0.043 min−1, P = 0.002). The rate constants seem to be related to the severity of the disease as defined by the Child–Pugh score.ConclusionsThe study suggests that PET with [11C]hyaluronan could be an accurate method by which to assess liver dysfunction, in conditions where endothelial cell function is impaired. The possibility of quantification over extended portions of the body also opens up possibilities to explore regional differences in liver function and to assess other elimination routes of hyaluronan.
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| 10. |
- Åslund, Olof, et al.
(författare)
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Labour market entry of non-labour migrants – Swedish evidence, IFAU Working paper 2017:15
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We describe the short- and long-term patterns of labour market entry and integration among Non-Western, predominantly non-labour, immigrants to Sweden. Our main sample considers the 1990-2014 period. The patterns of time to first contact and labour market entry vary with business cycle conditions, country of origin and other background characteristics. But the main message is the remarkable stability of a relatively slow entry process and long-term outcomes below those of the average worker. The number of jobs before the “first real job” (entry) is limited and the first employer contact is for many a port to a more stable position. First jobs are comparatively often found in small, low-wage firms, which over time have become increasingly present in service industries. Our discussion of policy experiences suggests several margins and factors affecting the labour market outcomes of recent migrants, but also indicates that no single reform or measure is likely to in itself radically change the patterns.
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