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- Kivipelto, Miia, et al.
(författare)
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The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) : Study design and progress
- 2013
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 9:6, s. 657-665
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Tidskriftsartikel (refereegranskat)abstract
- Background: Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland. Materials: Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-intervention studies. Inclusion criteria are CAIDE Dementia Risk Score >= 6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures. Results: Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle related factors are present, creating a window of opportunity for prevention. The intervention will be completed during 2014. Conclusions: The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing intervention strategies to prevent or delay the onset of cognitive impairment and dementia.
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| 2. |
- Lehtisalo, Jenni, et al.
(författare)
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Dietary changes and cognition over 2 years within a multidomain intervention trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
- 2019
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 15:3, s. 410-417
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age.Methods: We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60-77 years) who were randomized to intensive multidomain intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed.Results: Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the intervention group (P = .008; P = .051 for groups combined).Discussion: Dietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.
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| 3. |
- Lindström, Dag, 1960-, et al.
(författare)
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Urban Order and Street Regulation in Seventeenth-Century Sweden
- 2008
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Ingår i: Journal of Early Modern History. - 1385-3783 .- 1570-0658. ; 12:3-4, s. 257-287
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Tidskriftsartikel (refereegranskat)abstract
- This article examines how, in the early modern towns of Stockholm and Åbo, royal interests, town planning, street building and maintenance, and street behavior related to ideas and ideals of urban order. Town laws and ordinances, royal letters and some town court records are employed to tell a story of royal interest in well-ordered, impressive, successful towns; various street plans for the capital and the smaller provincial towns; and the varying execution of renewal plans. It is evident that the capital was to reflect the royal person and the state and that streets and street behaviour were important in this regard. But in towns outside the capital, especially in concrete street maintenance, the centrality of streets does not clearly emerge. The burghers in towns operated as individuals—there was no bottom-up or top-down plan or supervision.
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| 5. |
- Lindström, Riitta
(författare)
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A system for modelling groundwater contamination in water supply areas - chloride contamination from road de-icing as an example
- 2006
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Ingår i: Nordic Hydrology. - 0029-1277 .- 1996-9694. ; 37:1, s. 41-51
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Tidskriftsartikel (refereegranskat)abstract
- A system for modelling groundwater contamination in water supply areas is presented, consisting of the flow and transport models, MACRO for the unsaturated zone and MOC for the groundwater zone, coupled to the geographical information system, IDRISI. A graphical user interface links the different parts of the system. The system was applied to a water supply area located close to a major road south of Stockholm. Chloride was used as an indicator in determining the risk for groundwater contamination from the road. The future chloride concentration in the aquifer was predicted and the effects of different pumping rates on the chemistry of the water supply well were tested. Modelling results showed that the chloride concentration in the aquifer will increase substantially due to road de-icing and that it will take decades to lower the chloride concentration down to the original background values after an end to the use of de-icing salt. The system may serve as a valuable tool in a planning context. Potential groundwater contamination scenarios can be simulated, and alternative groundwater management strategies can be evaluated.
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| 6. |
- Lindström, Riitta, 1957-
(författare)
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Groundwater vulnerability assessment using process-based models
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The focus of this thesis is on groundwater vulnerability assessment by process-based simulation models and data acquisition for these assessments. A modelling system for intrinsic groundwater vulnerability assessment in water supply areas was developed, consisting of flow- and transport models for the unsaturated zone and the groundwater zone, coupled to a geographical informa-tion system. The system was applied to a water supply area located close to a major road south of Stockholm. Chloride was used as an indicator in determining the vulnerability for groundwater contamination from the road. The approach was useful to illustrate the dynamic change of chlo-ride concentrations both during the stage of continuous application and after the applications was terminated. A structure and content of a database for flow and transport modelling, based on hydrogeological environments, was outlined. An existing hydrogeological parameter database, HPAR at the Geological Survey of Sweden (SGU), was examined as a potential source of data for the new database. Values for some important parameters needed for groundwater modelling, such as hydraulic conductivity and effective porosity, were lacking in the three municipal HPAR databases that were studied. It was suggested that these data should be added, together with information on the hydrogeological environments, for all geographical positions of interest. Without such minimum information, the efficient use of modelling tools could not be expected. Typical profiles of three common Swedish hydrogeological environments (sand deposits, glacial till and clay covered areas) were used to represent generic input data to model simulations in the unsaturated zone so that the importance of soil, vegetation type and groundwater levels on turn-over times of conservative contaminants transported by natural recharge could be examined. The same profiles were used to predict the penetration depth of accidental liquid spills that occur at the land surface level. In the case of contaminant transport by natural recharge, water storage in the soil profile and vegetation type played an important role for turnover times. For liquid spills, the hydraulic con-ductivity was found to be of major importance, while the water retention properties were of less importance. Modelling, together with available data sources, were successfully used to demon-strate the vulnerability of different environmental conditions.
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