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Sökning: WFRF:(Lindström Tobias)

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1.
  • Agholme, Lotta, et al. (författare)
  • An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons
  • 2010
  • Ingår i: Journal of Alzheimer's Disease. - Ios Press. - 1387-2877 .- 1875-8908. ; 20:4, s. 1069-1082
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Neuroscience, including research on Alzheimers disease, is hampered by the lack of suitable in vitro models to study the human nervous system. To counteract this, many attempts to differentiate cell lines into more neuron-like cells have been performed, resulting in partial expression of neuronal features. Furthermore, it has been reported that neuroblastoma cell lines lack mature isoforms of tau. Our aim was to develop an improved in vitro model, generating sustainable cells with morphology and biochemistry of human, mature neurons. To obtain cells with neuronal differentiation and function, we investigated the effect of combining three-dimensional culturing of SH-SY5Y cells in extracellular matrix (ECM) gel with several factors reported to have neuro-differentiating effects. This resulted in cells with apparent neuronal morphology with long, extensively branched neurites. Further investigation revealed expression of several neurospecific markers including synapse protein Sv2 and nuclear marker NeuN, as well as the presence of synapses and axonal vesicle transport. In addition, these cells expressed mature tau isoforms, and tau protein expression was significantly increased compared to undifferentiated cells, reaching levels found in adult human brain. In conclusion, we found that pre-treatment with retinoic acid followed by ECM gel culturing in combination with brain derived neurotrophic factor, neuregulin beta(1), nerve growth factor, and vitamin D-3 treatment generated sustainable cells with unambiguous resemblance to adult neurons. These cells also expresses adult splicing forms of tau with neuronal localization, making this cellular in vitro model useful in many areas of neuroscience research, particularly the Alzheimers disease field.</p>
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5.
  • Bauch, Thilo, 1972-, et al. (författare)
  • YBCOSQUIDs with unconventional current phase relation
  • 2007
  • Ingår i: Physica C: Superconductivity and its Applications. - 0921-4534. ; 463-465:1 October 2007, s. 979-984
  • Tidskriftsartikel (refereegranskat)abstract
    • We have studied the dynamics of YBa2Cu3O7-delta,5 (YBCO) dc sperconducting quantum interference devices (SQUIDs) characterized by an unconventional Josephson current phase relation (CPR). We have focused on SQUID configurations with Josephson junctions where the lobe of the order parameter in one electrode is facing a node in the other electrode. This order parameter arrangement should enhance the appearance of a sin(2(p) term in the CPR. The response of the critical current of the dc SQUID, under the effect of an external magnetic field, has been measured in temperature, down to 20 mK. Our experimental data have been compared with numerical simulations of the SQUIDs dynamics by considering a CPR of a single junction of the form I(phi) = I-I sin(phi) - I-II sin(2 phi) where I-I, and I-II are, respectively, the first and second harmonic component. In our devices the values of the sin(2 phi) term are such that the fundamental state of the SQUID is naturally double degenerate. This is of great relevance for applications of d-wave SQUIDs in quantum information processing. (C) 2007 Elsevier B.V. All rights reserved.
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6.
  • Benselfelt, Tobias, et al. (författare)
  • Explaining the Exceptional Wet Integrity of Transparent Cellulose Nanofibril Films in the Presence of Multivalent Ions : Suitable Substrates for Biointerfaces
  • 2019
  • Ingår i: Advanced Materials Interfaces. - Wiley-VCH Verlagsgesellschaft. - 2196-7350. ; 13:6
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Cellulose nanofibrils (CNFs) assemble into water‐resilient materials in the presence of multivalent counter‐ions. The essential mechanisms behind these assemblies are ion–ion correlation and specific ion effects. A network model shows that the interfibril attraction indirectly influences the wet modulus by a fourth power relationship to the solidity of the network (<em>E</em><sub>w</sub> ∝ φ<sup>4</sup>). Ions that induce both ion–ion correlation and specific ion effects significantly reduce the swelling of the films, and due to the nonlinear relationship dramatically increase the wet modulus. Herein, this network model is used to explain the elastoplastic behavior of wet films of 2,2,6,6‐tetramethylpiperidine‐1‐oxyl radical (TEMPO)‐oxidized, carboxymethylated, and phosphorylated CNFs in the presence of different counter‐ions. The main findings are that the aspect ratio of the CNFs influences the ductility of the assemblies, that the bivalency of phosphorylate ligands probably limits the formation of interfibril complexes with divalent ions, and that a higher charge density increases the friction between fibrils by increasing the short‐range attraction from ion–ion correlation and specific ion effects. These findings can be used to rationally design CNF materials for a variety of applications where wet strength, ductility, and transparency are important, such as biomaterials or substrates for bioelectronics.</p><p></p>
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  • Bergqvist, Joakim, et al. (författare)
  • Detection and Isolation of Sindbis Virus from Mosquitoes Captured During an Outbreak in Sweden, 2013
  • 2015
  • Ingår i: Vector Borne and Zoonotic Diseases. - 1530-3667 .- 1557-7759. ; 15:2, s. 133-140
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Mosquito-borne alphaviruses have the potential to cause large outbreaks throughout the world. Here we investigated the causative agent of an unexpected Sindbis virus (SINV) outbreak during August-September, 2013, in a previously nonendemic region of Sweden. Mosquitoes were collected using carbon dioxide-baited CDC traps at locations close to human cases. The mosquitoes were initially screened as large pools by SINV-specific quantitative RT-PCR, and the SINV-positive mosquitoes were species determined by single-nucleotide polymorphism (SNP) analysis, followed by sequencing the barcoding region of the cytochrome oxidase I gene. The proportion of the collected mosquitoes was determined by a metabarcoding strategy. By using novel strategies for PCR screening and genetic typing, a new SINV strain, Lovanger, was isolated from a pool of 1600 mosquitoes composed of Culex, Culiseta, and Aedes mosquitoes as determined by metabarcoding. The SINV-positive mosquito Culiseta morsitans was identified by SNP analysis and sequencing. After whole-genome sequencing and phylogenetic analysis, the SINV Lovanger isolate was shown to be most closely similar to recent Finnish SINV isolates. In conclusion, within a few weeks, we were able to detect and isolate a novel SINV strain and identify the mosquito vector during a sudden SINV outbreak.</p>
9.
  • Burnett, J., et al. (författare)
  • PC2: Identifying noise processes in superconducting resonators
  • 2013
  • Ingår i: 2013 IEEE 14th InternationalSuperconductive Electronics Conference, ISEC 2013. - 9781467363716 ; s. Art. no. 6604284
  • Konferensbidrag (refereegranskat)abstract
    • Extensive studies of dielectric loss due to two level fluctuators (TLFs) in superconducting resonators have provided routes for low loss resonators. The research is motivated not only by the use of resonators as detectors and in quantum information processing, but more generally due to TLFs being a source of noise and decoherence in all quantum devices. In this work a frequency locked loop was used to measure frequency fluctuations at timescales in excess of 104 seconds, thereby accurately probing the TLF induced low- frequency noise of the resonator. Our measurement method lead to very high statistical confidence even for very long timescales, and here we can therefore present results explicitly identifying power dependent flicker frequency noise (S = 1/fa where a=1) persisting down to the mHz level.
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10.
  • Cinthio, Magnus, et al. (författare)
  • An automatic method for measurements of arterial intima-media thickness using ultrasonic B-mode data
  • 2012
  • Ingår i: 31st International Symposium on Acoustical Imaging,Warsaw, Poland,2011-04-10 - 2011-04-13. - Springer.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • We have previously developed algorithms that use B-mode cineloops for simultaneous measurements of arterial diameter change and longitudinal movement of the arterial wall. In this study the lumen diameter algorithm was extended to also measure arterial intima-media thickness of the far wall. To optimize the algorithm the influence of the lateral width of the region-of-interest (1 pixel, 0.1 mm, 0.5 mm, 1 mm, 2.5 mm and 5 mm) was evaluated. The algorithm estimated intima-media thickness at diastole automatically by measuring the distance between the two positions where the laterally averaged B-mode intensity envelope crosses a threshold value relative to the maximum amplitudes of the intimal and adventitial echoes, respectively. The sub-pixel resolution is achieved by solving the equation of a straight line between the two samples on either side of the threshold value. The measurements were performed on 20 healthy normotensive volunteers (age 25–57 years) on the common carotid artery 2–3 cm proximal to the bifurcation. For the 2.5-mm width, which was considered the best, the intima-media thickness was mean 646 μm (SD 66) for men and 613 μm (SD 68) for women. The systematic difference was −5 μm and the random difference was 31 μm. The CV was 4.9%. The study indicates that the reproducibility is sufficient for in vivo studies when the width of the region-of-interest is 1.0 mm or wider.
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