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Sökning: WFRF:(Liu Qinghua)

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  • Sun, Yan, et al. (författare)
  • Hydrogen sulfide upregulates K-ATP channel expression in vascular smooth muscle cells of spontaneously hypertensive rats
  • 2015
  • Ingår i: Journal of Molecular Medicine. - Springer Publishing Company. - 0946-2716 .- 1432-1440. ; 93:4, s. 439-455
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The study was designed to investigate whether H2S could upregulate expression of K-ATP channels in vascular smooth muscle cells (VSMCs), and by this mechanism enhances vasorelaxation in spontaneously hypertensive rats (SHR). Blood pressure, vascular structure, and vasorelaxation were analyzed. Plasma H2S was detected using polarographic sensor. SUR2B and Kir6.1 expressions were detected in VSMCs of SHR and in A7r5 cells as well as primarily cultured ASMCs using real-time PCR, western blot, immunofluorescence, and confocal imaging. Nuclear translocation of forkhead transcription factors FOXO1 and FOXO3a in ASMCs was detected using laser confocal microscopy, and their binding activity with SUR2B and Kir6.1 promoters was examined by chromatin immunoprecipitation. SHR developed hypertension at 18 weeks. They showed downregulated vascular SUR2B and Kir6.1 expressions in association with a decreased plasma H2S level. H2S donor, however, could upregulate vascular SUR2B and Kir6.1 expressions, causing a left shift of the vasorelaxation curve to pinacidil and lowered tail artery pressure in the SHR. Also, H2S antagonized endothelin-1 (ET-1)-inhibited K-ATP expression in A7r5 cells and cultured ASMCs. Mechanistically, H2S inhibited ET-1-stimulated p-FOXO1 and p-FOXO3a expressions (inactivated forms), but increased their nuclear translocation and the ET-1-inhibited binding of FOXO1 and FOXO3a with Kir6.1 and SUR2B promoters in ASMCs. Hence, H2S promotes vasorelaxation of SHR, at least in part, through upregulating the expression of K-ATP subunits by inhibiting phosphorylation of FOXO1 and FOXO3a, and stimulating FOXO1 and FOXO3a nuclear translocation and their binding activity with SUR2B and Kir6.1 promoters. H2S increased vascular SUR2B and Kir6.1 expression of SHR, promoting vasorelaxation. H2S antagonized ET-1-inhibited K-ATP expression in A7r5 cells and cultured ASMCs. H2S inhibited ET-1-induced FOXO1 and FOXO3a phosphorylation in ASMCs. H2S promoted FOXO1 and FOXO3a nuclear translocation and binding with target gene promoters.</p>
  • Fu, Jianjie, et al. (författare)
  • High levels of heavy metals in rice (Oryza sativa L.) from a typical E-waste recycling area in southeast China and its potential risk to human health
  • 2008
  • Ingår i: Chemosphere. - 0045-6535 .- 1879-1298. ; 71:7, s. 1269-1275
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Very few studies have investigated the heavy metal contents in rice samples from a typical E-waste recycling area. In this study, 10 heavy metals (As, Ba, Cd, Co, Cr, Cu, Hg, Mn, Ni and Pb) in 13 polished rice and relevant hull samples, six relevant paddy soil samples were investigated. The geometric mean concentrations of Cd, Cu and Hg in soil samples were 1.19, 9.98 and 0.32 microg g(-1), respectively, which were 4.0, 2.0 and 1.1-folds of the maximum allowable concentration (MAC) (0.30, 50.00, 0.30 microg g(-1), respectively) for Chinese agricultural soils. The analyzed metal concentrations were significantly different between rice and relevant hull except for As, Cd and Hg (p&lt;0.05). All metal concentrations, except for Co, in rice hull were higher than those in polished rice. The geometric mean of Pb in polished rice reached 0.69 microg g(-1), which was 3.5-folds higher than the MAC (0.20 microg g(-1)) by the safety criteria for milled rice. Cd contents in 31% of the rice samples exceeded the national MAC (0.20 microg g(-1)), and the arithmetic mean also slightly exceeded national MAC. In addition, Cd and Pb contents in local rice were much higher than commercial rice samples examined in this work and previous studies. Comparing the tolerable daily intakes given by FAO/WHO with the mean estimated daily intakes; Pb daily intake through rice consumption in this area was 3.7 microg day(-1)kg(-1) body weight (bw), which already exceeded the FAO tolerable daily intake, and the Cd daily intake (0.7 microg day(-1)kg(-1) bw) through rice had already taken up 70% of the total tolerable daily intake (1 microg day(-1)kg(-1) bw). The daily intake of Hg and As through rice was much lower than the tolerable daily intakes, but bioaccumulation of Hg through the food chain and intake of As from other food stuff should also be of concern.</p>
  • Abbas, Ghazanfar, et al. (författare)
  • Study of CuNiZnGdCe-Nanocomposite Anode for Low Temperature SOFC
  • 2012
  • Ingår i: Nanoscience and Nanotechnology Letters. - 1941-4900. ; 4:4, s. 389-393
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Composite electrodes of Cu0.16Ni0.27Zn0.37Ce0.16Gd0.04 (CNZGC) oxides have been successfully synthesized by solid state reaction method as anode material for low temperature solid oxide fuel cell (LTSOFC). These electrodes are characterized by XRD followed by sintering at various time periods and temperatures. Particle size of optimized composition was calculated 40-85 nm and sintered at 800 degrees C for 4 hours. Electrical conductivity of 4.14 S/cm was obtained at a temperature of 550 degrees C by the 4-prob DC method. The activation energy was calculated 4 x 10(-2) eV at 550 degrees C. Hydrogen was used as fuel and air as oxidant at anode and cathode sides respectively. I-V/I-P curves were obtained in the temperature range of 400-550 degrees C. The maximum power density was achieved for 570 mW/cm(2) at 550 degrees C.</p>
  • Jing, Yifu, et al. (författare)
  • Synthesis and electrochemical performances of linicuzn oxides as anode and cathode catalyst for low temperature solid oxide fuel cell
  • 2012
  • Ingår i: Journal of Nanoscience and Nanotechnology. - 1533-4880 .- 1533-4899. ; 12:6, s. 5102-5105
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Low temperature solid oxide fuel cell (LTSOFC, 300-600 °C) is developed with advantages compared to conventional SOFC (800-1000 °C). The electrodes with good catalytic activity, high electronic and ionic conductivity are required to achieve high power output. In this work, a LiNiCuZn oxides as anode and cathode catalyst is prepared by slurry method. The structure and morphology of the prepared LiNiCuZn oxides are characterized by X-ray diffraction and field emission scanning electron microscopy. The LiNiCuZn oxides prepared by slurry method are nano Li 0.28Ni 0.72O, ZnO and CuO compound. The nano-crystallites are congregated to form ball-shape particles with diameter of 800-1000 nm. The LiNiCuZn oxides electrodes exhibits high ion conductivity and low polarization resistance to hydrogen oxidation reaction and oxygen reduction reaction at low temperature. The LTSOFC using the LiNiCuZn oxides electrodes demonstrates good cell performance of 1000 mW cm -2 when it operates at 470 °C. It is considered that nano-composite would be an effective way to develop catalyst for LTSOFC.</p>
  • Karamyshev, Andrey L., et al. (författare)
  • Inefficient SRP Interaction with a Nascent Chain Triggers a mRNA Quality Control Pathway
  • 2014
  • Ingår i: Cell. - 0092-8674 .- 1097-4172. ; 156:1-2, s. 146-157
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Misfolded proteins are often cytotoxic, unless cellular systems prevent their accumulation. Data presented here uncover a mechanism by which defects in secretory proteins lead to a dramatic reduction in their mRNAs and protein expression. When mutant signal sequences fail to bind to the signal recognition particle (SRP) at the ribosome exit site, the nascent chain instead contacts Argonaute2 (Ago2), and the mutant mRNAs are specifically degraded. Severity of signal sequence mutations correlated with increased proximity of Ago2 to nascent chain and mRNA degradation. Ago2 knockdown inhibited degradation of the mutant mRNA, while overexpression of Ago2 or knockdown of SRP54 promoted degradation of secretory protein mRNA. The results reveal a previously unappreciated general mechanismof translational quality control, in which specific mRNA degradation preemptively regulates aberrant protein production (RAPP).</p>
  • Li, Yingming, et al. (författare)
  • Study of PCBs and PBDEs in King George Island, Antarctica, using PUF passive air sampling
  • 2012
  • Ingår i: Atmospheric Environment. - Elsevier. - 1352-2310 .- 1873-2844. ; 51, s. 140-145
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Polyurethane foam (PUF)-disk based passive air samplers were deployed in King George Island, Antarctica, during the austral summer of 2009-2010, to investigate levels, distributions and potential sources of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in Antarctic air. The atmospheric levels of Sigma indicator PCBs and Sigma(14) PBDEs ranged from 1.66 to 6.50 pg m(-3) and from 0.67 to 2.98 pg m(-3), respectively. PCBs homologue profiles were dominated by di-PCBs, tri-PCBs and tetra-PCBs, whereas BDE-17 and BDE-28 were the predominant congeners of PBDEs, which could be explained by long-range atmospheric transport processes. However, the sampling sites close to the Antarctic research stations showed higher atmospheric concentrations of PCBs and PBDEs than the other sites, reflecting potential local sources from the Antarctic research stations. The non-Aroclor congener PCB-11 was found in all the air samples, with air concentrations of 3.60-31.4 pg m(-3) (average 15.2 pg m(-3)). Comparison between the results derived from PUF-disk passive air sampling and high-volume air sampling validates the feasibility of using the passive air samplers in Antarctic air. To our knowledge, this study is the first employment of PUF-disk based passive air samplers in Antarctic atmosphere.</p>
  • Li, ZongYi, et al. (författare)
  • Toward a stem cell gene therapy for breast cancer
  • 2009
  • Ingår i: Blood. - American Society of Hematology. - 1528-0020. ; 113:22, s. 5423-5433
  • Tidskriftsartikel (refereegranskat)abstract
    • Current approaches for treatment of late-stage breast cancer rarely result in a long-term cure. In part this is due to tumor stroma that prevents access of systemically or intratumorally applied therapeutics. We propose a stem cell gene therapy approach for controlled tumor stroma degradation that uses the pathophysiologic process of recruitment of inflammatory cells into the tumor. This approach involves genetic modification of hematopoietic stem cells (HSCs) and their subsequent transplantation into tumor-bearing mice. We show that inducible, intratumoral expression of relaxin (Rlx) either by transplanting tumor cells that contained the Rlx gene or by transplantation of mouse HSCs transduced with an Rlx-expressing lentivirus vector delays tumor growth in a mouse model of breast cancer. The antitumor effect of Rlx was mediated through degradation of tumor stroma, which provided increased access of infiltrating antitumor immune cells to their target tumor cells. Furthermore, we have shown in a human/mouse chimeric model that genetically modified HSCs expressing a transgene can access the tumor site. Our findings are relevant for cancer gene therapy and immunotherapy. (Blood. 2009; 113: 5423-5433)
  • Liu, Qinghua, et al. (författare)
  • Theoretical description of superionic conductivities in samaria doped ceria based nanocomposites
  • 2010
  • Ingår i: Applied Physics Letters. - 0003-6951 .- 1077-3118. ; 97:18, s. 183115
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Superionic conductivity becomes true based on recent developments on ceria-based nanocomposites as electrolytes with application for low temperature (300-600 degrees C) solid oxide fuel cells. We theoretically describe the superionic conductivity phenomena in samaria doped ceria nanocomposites. An improved effective-medium model was used to determine the ionic conductivity of the materials focusing on a core-shell structure of the as-prepared samaria doped ceria based composite particles. This work reveals the enhancement of ionic conductivity by interface proton and oxygen ion transportation in the composites, which agrees well with the experimental results.</p>
  • Qin, Haiying, et al. (författare)
  • Direct biofuel low-temperature solid oxide fuel cells
  • 2011
  • Ingår i: ENERGY & ENVIRONMENTAL SCIENCE. - 1754-5692. ; 4:4, s. 1273-1276
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>A low-temperature solid oxide fuel cell system was developed to use bioethanol and glycerol as fuels directly. This system achieved a maximum power density of 215 mW cm(-2) by using glycerol at 580 degrees C and produced a great impact on sustainable energy and the environment.</p>
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