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Airway contraction ...
Airway contraction and cytokine release in isolated rat lungs induced by wear particles from the road and tire interface and road vehicle brakes
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- Nosratabadi, Ali Reza (author)
- Linköping University,Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin
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- Gustafsson, Mats, 1966- (author)
- Swedish National Road and Transport Research Institute,Statens väg- och transportforskningsinstitut,Miljö, MILJÖ,Swedish National Road and Transport Research Institute (VTI), Linköping, Sweden,Swedish Natl Rd & Transport Res Inst VTI, Linkoping, Sweden
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- Lovén, Karin (author)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Ljunggren, Stefan (author)
- Linköping University,Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin
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- Olofsson, Ulf, 1962- (author)
- KTH Royal Institute of Technology,KTH,Maskinkonstruktion (Avd.),Royal Inst Technol KTH, Sweden
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- Abbasi, Saeed (author)
- KTH Royal Institute of Technology,KTH,Maskinkonstruktion (Avd.),Royal Inst Technol KTH, Sweden
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- Blomqvist, Göran, 1963- (author)
- Swedish National Road and Transport Research Institute,Statens väg- och transportforskningsinstitut,Miljö, MILJÖ,Swedish National Road and Transport Research Institute (VTI), Linköping, Sweden,Swedish Natl Rd & Transport Res Inst VTI, Linkoping, Sweden
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- Karlsson, Helen (author)
- Linköping University,Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin
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- Ljungman, Anders (author)
- Linköping University,Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Cassee, Flemming R. (author)
- National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands,Natl Inst Publ Hlth & Environm, Netherlands; Univ Utrecht, Netherlands
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- Gerlofs-Nijland, Miriam E. (author)
- National Institute for Public Health and the Environment, Bilthoven, The Netherlands,Natl Inst Publ Hlth & Environm, Netherlands,National Institute for Public Health and the Environment (RIVM)
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- Gudmundsson, Anders (author)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,MERGE: ModElling the Regional and Global Earth system,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,LTH profilområde: Aerosoler,LTH profilområden,LTH profilområde: Nanovetenskap och halvledarteknologi,Other operations, LTH,Faculty of Engineering, LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Centre for Environmental and Climate Science (CEC),Faculty of Science,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,Faculty of Engineering, LTH
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(creator_code:org_t)
- Taylor & Francis, 2023
- 2023
- English.
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In: Inhalation Toxicology. - : Taylor & Francis. - 0895-8378 .- 1091-7691. ; 35:13-14, s. 309-323
- Related links:
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https://doi.org/10.1...
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https://vti.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- The dominant road traffic particle sources are wear particles from the road and tire interface, and from vehicle brake pads. The aim of this work was to investigate the effect of road and brake wear particles on pulmonary function and biomarkers in isolated perfused rat lungs. Particles were sampled from the studded tire wear of three road pavements containing different rock materials in a road simulator; and from the wear of two brake pad materials using a pin-on-disk machine. Isolated rat lungs inhaled the coarse and fine fractions of the sampled particles resulting in an estimated total particle lung dose of 50 μg. The tidal volume (TV) was measured during the particle exposure and the following 50 min. Perfusate and BALF were analyzed for the cytokines TNF, CXCL1 and CCL3. The TV of lungs exposed to rock materials was significantly reduced after 25 min of exposure compared to the controls, for quartzite already after 4 min. The particles of the heavy-duty brake pads had no effect on the TV. Brake particles resulted in a significant elevation of CXCL1 in the perfusate. Brake particles showed significant elevations of all three measured cytokines, and quartzite showed a significant elevation of TNF in BALF. The study shows that the toxic effect on lungs exposed to airborne particles can be investigated using measurements of tidal volume. Furthermore, the study shows that the choice of rock material in road pavements has the potential to affect the toxicity of road wear PM10.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Tribologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Tribology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Pulmonary disorders
- road wear particles
- brake wear particles
- tidal volume
- biomarkers
- isolated perfused lung
- biomarkers
- brake wear particles
- isolated perfused lung
- Pulmonary disorders
- road wear particles
- tidal volume
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nosratabadi, Ali ...
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Gustafsson, Mats ...
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Lovén, Karin
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Ljunggren, Stefa ...
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Olofsson, Ulf, 1 ...
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Abbasi, Saeed
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Blomqvist, Göran ...
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Karlsson, Helen
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Ljungman, Anders
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Cassee, Flemming ...
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Gerlofs-Nijland, ...
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Gudmundsson, And ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Mechanical Engin ...
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and Tribology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Inhalation Toxic ...
- By the university
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VTI - The Swedish National Road and Transport Research Institute
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Royal Institute of Technology
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Linköping University
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Lund University