↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Lo Wing Yee) ;pers:(Giles Graham G)"

Search: WFRF:(Lo Wing Yee) > Giles Graham G

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Ahearn, Thomas U., et al. (author) Common variants in breast cancer risk loci predispose to distinct tumor subtypes 2022 In: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1 Journal article (peer-reviewed)abstract BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
2.	Wu, Lang, et al. (author) A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 2018 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:7, s. 968-978 Journal article (peer-reviewed)abstract , including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Olsson, Håkan (2); Nevanlinna, Heli (2); Blomqvist, Carl (2); Chang-Claude, Jenny (2); Kaaks, Rudolf (2); Wang, Qin (2); show more...; Wolk, Alicja (2); Haiman, Christopher ... (2); Gapstur, Susan M (2); Giles, Graham G (2); Brenner, Hermann (2); John, Esther M (2); Gago Dominguez, Manu ... (2); Arndt, Volker (2); Rennert, Gad (2); Canzian, Federico (2); Michailidou, Kyriaki (2); Milne, Roger L. (2); Bolla, Manjeet K. (2); Dennis, Joe (2); Dunning, Alison M. (2); Andrulis, Irene L. (2); Anton-Culver, Hoda (2); Aronson, Kristan J. (2); Auer, Paul L. (2); Benitez, Javier (2); Bermisheva, Marina (2); Bojesen, Stig E. (2); Brauch, Hiltrud (2); Burwinkel, Barbara (2); Chenevix-Trench, Geo ... (2); Clarke, Christine L. (2); Cox, Angela (2); Cross, Simon S. (2); Czene, Kamila (2); Daly, Mary B. (2); Devilee, Peter (2); Dwek, Miriam (2); Eccles, Diana M. (2); Fasching, Peter A. (2); Figueroa, Jonine (2); Gaudet, Mia M. (2); Goldberg, Mark S. (2); Gonzalez-Neira, Anna (2); Guenel, Pascal (2); Hall, Per (2); Hamann, Ute (2); Hollestelle, Antoine ... (2); Hoover, Robert N. (2); Hopper, John L. (2); show less...

University: Uppsala University (2); Lund University (2); Karolinska Institutet (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view