SwePub - sökning: WFRF:(Longo Nancy S)

Numrering	Referens	Omslagsbild	Hitta
1.	Viau, Muriel, et al. (författare) Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L 2004 Ingår i: Infection and Immunity. - 1098-5522. ; 72:6, s. 3515-3523 Tidskriftsartikel (refereegranskat)abstract Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense.

Viau, Muriel, et al. (författare)
Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L
2004
Ingår i: Infection and Immunity. - 1098-5522. ; 72:6, s. 3515-3523
Tidskriftsartikel (refereegranskat)abstract
- Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense.

Träfflista för sökning "WFRF:(Longo Nancy S) "