Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data

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Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data

Zardavas, Dimitrios (author): Breast Int Grp, Belgium,Breast International Group

te Marvelde, Luc (author): Canc Council, Australia

Milne, Roger L. (author): Canc Council, Australia; Univ Melbourne, Australia,University of Melbourne

Fumagalli, Debora (author): Breast Int Grp, Belgium,Breast International Group

Fountzilas, George (author): Aristotle Univ Thessaloniki, Greece,Aristotle University of Thessaloniki

Kotoula, Vassiliki (author): Aristotle Univ Thessaloniki, Greece,Aristotle University of Thessaloniki

Razis, Evangelia (author): Hygeia Hosp, Greece,Hygeia Hospital

Papaxoinis, George (author): Hippokrateion Hosp, Greece,Hippokration Hospital

Joensuu, Heikki (author): Helsinki Univ Hosp, Finland; Univ Helsinki, Finland,University of Helsinki,Helsinki University Central Hospital,Leiden University Medical Centre,Leiden Univ, Netherlands

Moynahan, Mary Ellen (author): Mem Sloan Kettering Canc Ctr, NY 10021 USA,Memorial Sloan-Kettering Cancer Center

Hennessy, Bryan T. (author): Beaumont Hosp, Ireland; Royal Coll Surg, Ireland,Beaumont Hospital, Dublin

Bieche, Ivan (author): Curie Inst, France,Curie Institute, Paris

Saal, Lao H. (author): Lund University,Lunds universitet,Translational Oncogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Sweden

Stål, Olle (author): Linköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US

Iacopetta, Barry (author): Univ Western Australia, Australia,University of Western Australia, Crawley

Jensen, Jeanette Dupont (author): Univ Southern Denmark, Denmark,University of Southern Denmark

OToole, Sandra (author): Garvan Inst Med Res, Australia,Garvan Institute of Medical Research

Lopez-Knowles, Elena (author): Garvan Inst Med Res, Australia; Royal Marsden NHS Trust, England; Inst Canc Res, England,Garvan Institute of Medical Research,Institute of Cancer Research London

Barbaraeschi, Mattia (author): Santa Chiara Hosp, Italy,Santa Chiara Hospital, Trento

Noguchi, Shinzaburo (author): Osaka Univ, Japan,Osaka University

Azim, Hatem A. Jr. (author): Amer Univ Beirut, Lebanon,American University of Beirut

Lerma, Enrique (author): Univ Autonoma Barcelona, Spain,Autonomous University of Barcelona

Bachelot, Thomas (author): Ctr Rech Cancerol Lyon, France,Centre de Recherche en Cancérologie de Lyon

Wang, Qing (author): Linköping University,Linköpings universitet

Perez Tenorio, Gizeh (author): Linköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten

de Velde, Cornelis J. H. Can (author): Leiden Univ, Netherlands

Rea, Daniel W. (author): Univ Birmingham, England,University of Birmingham

Sabine, Vicky (author): Univ Guelph, Canada,University of Guelph

Bartlett, John M. S. (author): Ontario Inst Canc Res, Canada,Ontario Institute for Cancer Research,University of Paris-Saclay,Gustave Roussy, France; Univ Paris Saclay, France

Sotiriou, Christos (author): Univ Libre Bruxelles, Belgium,Université Libre de Bruxelles (ULB)

Michiels, Stefan (author): Gustave Roussy, France; Univ Paris Saclay, France

Loi, Sherene (author): Univ Melbourne, Australia,University of Melbourne

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AMER SOC CLINICAL ONCOLOGY, 2018
2018
English.
In: Journal of Clinical Oncology. - : AMER SOC CLINICAL ONCOLOGY. - 0732-183X .- 1527-7755. ; 36:10, s. 981-

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; http://dx.doi.org/10...; https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

PurposePhosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data.Patients and MethodsAssociations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted for age, tumor size, nodes, grade, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, treatment, and study. Invasive disease-free survival (IDFS) was the primary end point; distant disease-free survival (DDFS) and overall survival (OS) were also assessed, overall and by breast cancer subtypes.ResultsData from 10,319 patients from 19 studies were included (median OS follow-up, 6.9 years); 1,787 patients (17%) received chemotherapy, 4,036 (39%) received endocrine monotherapy, 3,583 (35%) received both, and 913 (9%) received none or their treatment was unknown. PIK3CA mutations occurred in 32% of patients, with significant associations with ER positivity, increasing age, lower grade, and smaller size (all P amp;lt; .001). Prevalence of PIK3CA mutations was 18%, 22%, and 37% in the ER-negative/HER2-negative, HER2-positive, and ER-positive/HER2-negative subtypes, respectively. In univariable analysis, PIK3CA mutations were associated with better IDFS (HR, 0.77; 95% CI, 0.71 to 0.84; P amp;lt; .001), with evidence for a stronger effect in the first years of follow-up (0 to 5 years: HR, 0.73; 95% CI, 0.66 to 0.81; P amp;lt; .001; 5 to 10 years: HR, 0.82; 95% CI, 0.68 to 0.99; P = .037); amp;gt; 10 years: (HR, 1.15; 95% CI, 0.84 to 1.58; P = .38; P heterogeneity = .02). In multivariable analysis, PIK3CA genotype remained significant for improved IDFS (P = .043), but not for the DDFS and OS end points.ConclusionIn this large pooled analysis, PIK3CA mutations were significantly associated with a better IDFS, DDFS, and OS, but had a lesser prognostic effect after adjustment for other prognostic factors. (C) 2018 by American Society of Clinical Oncology

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Journal of Clini ...

By the university: Linköping University; Lund University

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Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data

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