SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lubke Gitta) "

Sökning: WFRF:(Lubke Gitta)

  • Resultat 1-7 av 7
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Campbell, Ian, et al. (författare)
  • The relation between the age at diagnosis of problem behaviors related to aggression and distal outcomes in Swedish children.
  • 2019
  • Ingår i: European child & adolescent psychiatry. - 1435-165X. ; 28:7, s. 899-911
  • Tidskriftsartikel (refereegranskat)abstract
    • Severe childhood aggressive behaviors are known to predict negative outcomes later in life; however, little is known about the effect of when in childhood aggression problems are diagnosed. While an earlier first diagnosis of problematic aggressive behavior might be associated with increased severity and, thus, worse outcomes, it is also possible that an earlier diagnosis affords an earlier start of treatment programs or indicates that greater attention is being paid to behavioral problems, thus resulting in attenuation of the severity of childhood aggression's impact on distal outcomes. The current study analyzed data from the population-based Swedish Data Registries, which include data on all children formally diagnosed by the Swedish medical system with a wide range of aggression problems between ages 8 and 18 (N = 5816) during the years 1987-2013, along with a matched control. Time-to-event analyses investigated whether the age at time of diagnosis affects later life outcomes while controlling for relevant confounders. Results show that for both boys and girls, those with a later diagnosis had lower average incomes (regression coefficient b = - 0.055, p < 0.005) and a higher probability of having a criminal record (odds ratio 1.126, p < 0.005) than children with earlier diagnoses. The effect on suicide attempts was not significant after correcting for multiple testing (odds ratio 1.264, p = 0.016). Grade score was not significantly affected. The results warrant further research concerning the potential advantage of earlier diagnoses, especially concerning generalizability beyond the Swedish population.
  •  
2.
  • Bolhuis, Koen, et al. (författare)
  • Disentangling Heterogeneity of Childhood Disruptive Behavior Problems Into Dimensions and Subgroups
  • 2017
  • Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry. - Elsevier. - 0890-8567 .- 1527-5418. ; 56:8, s. 678-686
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>Objective</strong>: Irritable and oppositional behaviors are increasingly considered as distinct dimensions of oppositional defiant disorder. However, few studies have explored this multidimensionality across the broader spectrum of disruptive behavior problems (DBPs). This study examined the presence of dimensions and distinct subgroups of childhood DBPs, and the cross-sectional and longitudinal associations between these dimensions.</p><p><strong>Method</strong>: Using factor mixture models (FMMs), the presence of dimensions and subgroups of DBPs was assessed in the Generation R Study at ages 6 (n = 6,209) and 10 (n = 4,724) years. Replications were performed in two population-based cohorts (Netherlands Twin Registry, n = 4,402, and Swedish Twin Study of Child and Adolescent Development, n = 1,089) and a clinical sample (n = 1,933). We used cross-lagged modeling in the Generation R Study to assess cross-sectional and longitudinal associations between dimensions. DBPs were assessed using mother-reported responses to the Child Behavior Checklist.</p><p><strong>Results</strong>: Empirically obtained dimensions of DBPs were oppositional behavior (age 6 years), disobedient behavior, rule-breaking behavior (age 10 years), physical aggression, and irritability (both ages). FMMs suggested that one-class solutions had the best model fit for all dimensions in all three population-based cohorts. Similar results were obtained in the clinical sample. All three dimensions, including irritability, predicted subsequent physical aggression (range, 0.08-0.16).</p><p><strong>Conclusion</strong>: This study showed that childhood DBPs should be regarded as a multidimensional phenotype rather than comprising distinct subgroups. Incorporating multidimensionality will improve diagnostic accuracy and refine treatment. Future studies need to address the biological validity of the DBP dimensions observed in this study; herein lies an important opportunity for neuro-imaging and genetic measures.</p>
  •  
3.
  • Campbell, Ian, et al. (författare)
  • The relation between the age at diagnosis of problem behaviors related to aggression and distal outcomes in Swedish children
  • 2019
  • Ingår i: European Child and Adolescent Psychiatry. - Springer. - 1018-8827 .- 1435-165X. ; 28:7, s. 899-911
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Severe childhood aggressive behaviors are known to predict negative outcomes later in life; however, little is known about the effect of when in childhood aggression problems are diagnosed. While an earlier first diagnosis of problematic aggressive behavior might be associated with increased severity and, thus, worse outcomes, it is also possible that an earlier diagnosis affords an earlier start of treatment programs or indicates that greater attention is being paid to behavioral problems, thus resulting in attenuation of the severity of childhood aggression's impact on distal outcomes. The current study analyzed data from the population-based Swedish Data Registries, which include data on all children formally diagnosed by the Swedish medical system with a wide range of aggression problems between ages 8 and 18 (N = 5816) during the years 1987-2013, along with a matched control. Time-to-event analyses investigated whether the age at time of diagnosis affects later life outcomes while controlling for relevant confounders. Results show that for both boys and girls, those with a later diagnosis had lower average incomes (regression coefficient b = - 0.055, p &lt; 0.005) and a higher probability of having a criminal record (odds ratio 1.126, p &lt; 0.005) than children with earlier diagnoses. The effect on suicide attempts was not significant after correcting for multiple testing (odds ratio 1.264, p = 0.016). Grade score was not significantly affected. The results warrant further research concerning the potential advantage of earlier diagnoses, especially concerning generalizability beyond the Swedish population.</p>
  •  
4.
  • Justice, Anne E, et al. (författare)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 8, s. 14977-14977
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.</p>
  •  
5.
  • Justice, Anne E., et al. (författare)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • Ingår i: Nature Communications. - NATURE PUBLISHING GROUP. - 2041-1723 .- 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.</p>
  •  
6.
  • Luningham, Justin M., et al. (författare)
  • Data Integration Methods for Phenotype Harmonization in Multi-Cohort Genome-Wide Association Studies With Behavioral Outcomes
  • 2019
  • Ingår i: Frontiers in Genetics. - Frontiers Media S.A.. - 1664-8021 .- 1664-8021. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Parallel meta-analysis is a popular approach for increasing the power to detect genetic effects in genome-wide association studies across multiple cohorts. Consortia studying the genetics of behavioral phenotypes are oftentimes faced with systematic differences in phenotype measurement across cohorts, introducing heterogeneity into the meta-analysis and reducing statistical power. This study investigated integrative data analysis (IDA) as an approach for jointly modeling the phenotype across multiple datasets. We put forth a bi-factor integration model (BFIM) that provides a single common phenotype score and accounts for sources of study-specific variability in the phenotype. In order to capitalize on this modeling strategy, a phenotype reference panel was utilized as a supplemental sample with complete data on all behavioral measures. A simulation study showed that a mega-analysis of genetic variant effects in a BFIM were more powerful than meta-analysis of genetic effects on a cohort-specific sum score of items. Saving the factor scores from the BFIM and using those as the outcome in meta-analysis was also more powerful than the sum score in most simulation conditions, but a small degree of bias was introduced by this approach. The reference panel was necessary to realize these power gains. An empirical demonstration used the BFIM to harmonize aggression scores in 9-year old children across the Netherlands Twin Register and the Child and Adolescent Twin Study in Sweden, providing a template for application of the BFIM to a range of different phenotypes. A supplemental data collection in the Netherlands Twin Register served as a reference panel for phenotype modeling across both cohorts. Our results indicate that model-based harmonization for the study of complex traits is a useful step within genetic consortia.</p>
  •  
7.
  • Mårland, Caroline, et al. (författare)
  • The development of a brief screener for autism using item response theory
  • 2019
  • Ingår i: BMC Psychiatry. - 1471-244X. ; 19
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Brief screening instruments focusing on autism spectrum disorder (ASD) that can be administered in primary care are scarce; there is a need for shorter and more precise instruments. The Autism-Tics, AD/HD and other Comorbidities inventory (A-TAC) has previously been validated for ASD reporting excellent validity. This study aims to determine the psychometric properties of each item in the ASD domain (17 items) in the A-TAC using item response theory (IRT), and thereby construct and validate a short form that could be used as a screening instrument in the general population. Methods: Since 2004, parents of all 9-year-old Swedish twins have been invited to participate in a telephone interview in the Child and Adolescent Twin Study in Sweden (CATSS). The CATSS is linked to the National Patient Register (NPR), which includes data from in- and outpatient care. Data on ASD (A-TAC) collected in CATSS were compared with diagnoses from the NPR. Diagnoses that had been made both before (previous validity) and after (predictive validity) the interviews were included. The sample was divided into a developmental sample and a validation sample. An IRT model was fitted to the developmental sample and item parameters were used to select a subset of items for the short form. The performance of the proposed short form was examined in the validation sample by the use of receiver operation characteristic curves. Results: Four items which were able to discriminate among individuals with more autism traits were deemed sufficient for use in the short form. The values of the area under the receiver operating characteristic curve for a clinical diagnosis of ASD was.95 (previous validity) and.72 (predictive validity). Conclusions: The proposed short form with 4 out of the original 17 items from A-TAC, showed excellent previous validity while the predictive validity was fair. The validity of the short form was in agreement with previous validations of the full ASD domain. The short form can be a valuable screening instrument in primary care settings in order to identify individuals in need for further assessment and for use in epidemiological studies.
Skapa referenser, mejla, bekava och länka
  • Resultat 1-7 av 7
Åtkomst
fritt online (3)
Typ av publikation
tidskriftsartikel (7)
Typ av innehåll
refereegranskat (7)
Författare/redaktör
Boomsma, Dorret I. (4)
Tiemeier, Henning (3)
Lind, Lars, (2)
Franks, Paul W, (2)
Karlsson, Magnus, (2)
Yengo, Loïc, (2)
visa fler...
Lobbens, Stéphane, (2)
Bonnefond, Amélie, (2)
Froguel, Philippe, (2)
De Borst, Gert J (2)
Raitakari, Olli T (2)
Kuh, Diana (2)
Haiman, Christopher ... (2)
Trompet, Stella (2)
Amin, Najaf (2)
Teumer, Alexander (2)
Blangero, John (2)
Curran, Joanne E. (2)
De Geus, Eco J. C. (2)
Ferrucci, Luigi (2)
Ford, Ian (2)
Gudnason, Vilmundur (2)
Hartman, Catharina A ... (2)
Homuth, Georg (2)
Montgomery, Grant W. (2)
Nauck, Matthias (2)
Psaty, Bruce M. (2)
Stott, David J. (2)
Uitterlinden, Andre ... (2)
Van Duijn, Cornelia ... (2)
Martin, Nicholas G. (2)
De Craen, Anton J. M ... (2)
Launer, Lenore J. (2)
Staessen, Jan A (2)
Strachan, David P. (2)
Marz, Winfried (2)
Hernandez, Dena (2)
Wareham, Nicholas J (2)
Stancáková, Alena, (2)
Kuusisto, Johanna, (2)
Laakso, Markku, (2)
McCarthy, Mark I (2)
Ahluwalia, Tarunveer ... (2)
Linneberg, Allan, (2)
Grarup, Niels, (2)
Pedersen, Oluf, (2)
Hansen, Torben, (2)
Ahmad, Shafqat, (2)
Ridker, Paul M., (2)
Chasman, Daniel I., (2)
visa färre...
Lärosäte
Örebro universitet (3)
Göteborgs universitet (2)
Umeå universitet (1)
Lunds universitet (1)
Uppsala universitet (1)
Karolinska Institutet (1)
Språk
Engelska (7)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (7)
Samhällsvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy