Sökning: WFRF:(Lundin Anna Carin)
> Gentile Massiliano >
Association between...
Association between CYP17 gene polymorphism and risk of breast cancer in young women
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- Bergman-Jungeström, Malin, 1967- (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Gentile, Massiliano (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Lundin, Anna-Carin (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Wingren, Sten, 1950- (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: International Journal of Cancer. - 0020-7136 .- 1097-0215. ; 84, s. 350-353
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Long-term exposure to oestrogens is a well-recognised risk factor for breast cancer, whereas little is known about the influence of polymorphisms of genes involved in oestrogen biosynthesis and metabolism. A candidate, containing a single bp polymorphism, T→C, (designated, A2 allele), might be the CYP17 gene, which codes for an enzyme involved in oestrogen synthesis. This polymorphism creates an additional Sp1-type promoter site (CCACC box), which has been shown to be associated with increased serum oestrogen levels. We performed a case-control study, to evaluate association of the CYP17 gene polymorphism with risk of breast cancer in young women (younger than 37 years). We found a statistically significant increased risk in carriers of at least 1 A2 allele [odds ratio (OR), 2.0; 95% confidence interval (CI), 1.1–3.5, p = 0.027], and a trend toward a gene-dose effect illustrated by a slightly higher risk for A2-homozygous subjects (OR, 2.8) than for heterozygous women (OR, 1.9). Furthermore, when we investigated the CYP17 genotype in relation to tumour characteristics, breast cancer patients with 1 or 2 A2 alleles tended to have lower oestrogen receptor levels (risk ratio, 0.70; CI, 0.41–1.2, p = 0.44). Our findings suggest that CYP17 gene polymorphism influences breast carcinogenesis in young women.
Nyckelord
- MEDICINE
- MEDICIN
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