| 1. |
|
|
| 2. |
|
|
| 3. |
- Hicks, J, et al.
(författare)
-
Novel patterns of genome rearrangement and their association with survival in breast cancer
- 2006
-
Ingår i: Genome research. - : Cold Spring Harbor Laboratory. - 1088-9051. ; 16:12, s. 1465-1479
-
Tidskriftsartikel (refereegranskat)abstract
- Representational Oligonucleotide Microarray Analysis (ROMA) detects genomic amplifications and deletions with boundaries defined at a resolution of ∼50 kb. We have used this technique to examine 243 breast tumors from two separate studies for which detailed clinical data were available. The very high resolution of this technology has enabled us to identify three characteristic patterns of genomic copy number variation in diploid tumors and to measure correlations with patient survival. One of these patterns is characterized by multiple closely spaced amplicons, or “firestorms,” limited to single chromosome arms. These multiple amplifications are highly correlated with aggressive disease and poor survival even when the rest of the genome is relatively quiet. Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer. Based on this sample, we generate the working hypothesis that copy number profiling might provide information useful in making clinical decisions, especially regarding the use or not of systemic therapies (hormonal therapy, chemotherapy), in the management of operable primary breast cancer with ostensibly good prognosis, for example, small, node-negative, hormone-receptor-positive diploid cases.
|
|
| 4. |
|
|
| 5. |
- Russnes, HG, et al.
(författare)
-
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
- 2010
-
Ingår i: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 2:38, s. 38ra47-
-
Tidskriftsartikel (refereegranskat)abstract
- This study demonstrates the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that an objective score of genomic complexity can provide independent prognostic information in breast cancer.
|
|
| 6. |
|
|
| 7. |
- Biémont, E, et al.
(författare)
-
Decay of metastable states in Nd II
- 2007
-
Ingår i: The European physical journal D Atomic, molecular and optical physics. ; 41, s. 211-
-
Tidskriftsartikel (refereegranskat)
|
|
| 8. |
- Biémont, É., et al.
(författare)
-
Decay of metastable states in NdII
- 2007
-
Ingår i: European Physical Journal D. - : Springer Science and Business Media LLC. - 1434-6060 .- 1434-6079. ; 41:2, s. 211-219
-
Tidskriftsartikel (refereegranskat)abstract
- The difficulty associated with an accurate determination of transition rates for forbidden lines in lowly ionized heavy elements is illustrated in the case of Nd II. We have investigated the radiative decay of the low-lying metastable levels in Nd+ including the two levels 4f(4)(I-5) 5d K-6(11/2) and 4f(4)(I-5) 5d I-6(13/2). In these two particular cases, using di. erent theoretical approaches, we. nd that the decay is dominated by the M1 channels but that the E2 contributions are of the same order of magnitude. These levels have also been studied experimentally by lifetime measurements with the heavy ion storage ring CRYRING of Stockholm University. The difficulties encountered when performing such experiments are underlined and discussed.
|
|
| 9. |
|
|
| 10. |
- Biemont, E, et al.
(författare)
-
Importance of an M2 depopulating channel for a KrII metastable state
- 2004
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 93:6, s. 063003-
-
Tidskriftsartikel (refereegranskat)abstract
- An experimental investigation of the radiative lifetime of the metastable 4s(2)4p(4)(P-3)4d D-4(7/2) level in Kr II shows an unusual situation regarding the importance of an M2 depopulation channel. While the first order M1 and E2 channels are expected to contribute in a dominant way to the decay, the experimental result, obtained using a laser probing technique on a stored ion beam, tau=0.57+/-0.03 s, is far too short to be due to these channels according to our relativistic multiconfiguration Dirac-Fock calculation. Only if second order contributions to the decay branches (including essentially the M2 contribution) are taken into account in the calculations could the unexpected short lifetime be explained.
|
|
