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  • Bakardjieva Engelbrekt, Antonina, et al. (författare)
  • The EU and Global Inbalances
  • 2015
  • Ingår i: EU fighting global imbalances. - : Edward Elgar Publishing. - 978 1 78471 672 1
  • Bokkapitel (övrigt vetenskapligt)
  • Dencker, Kerstin, 1972-, et al. (författare)
  • Characteristic of a proactive assembly system
  • 2008
  • Konferensbidrag (refereegranskat)abstract
    • Competitive assembly systems must cope with frequent demand changes, requiring drastically shortened resetting and ramp-up times. Characteristics of assembly systems capable of rapid change are e.g. Flexibility; Robustness, Agility, and ability to handle frequent changes and disturbances. This paper proposes proactivity as a vital factor of semi-automated assembly systems to increase speed of change. Proactive systems utilize the full potential of human operators and technical systems. Such systems have ability to dynamically change system automation levels, resulting in decrease of time consumed for assembly tasks. Proactivity criteria for assembly systems are reviewed based on theory and industrial case studies
  • Martensson, T., et al. (författare)
  • Clinical relevance of endoscopy with histopathological assessment in children with suspected gastrointestinal graft-versus-host disease
  • 2020
  • Ingår i: Clinical Transplantation. - : Wiley. - 0902-0063 .- 1399-0012. ; 34:7, s. e13867-
  • Tidskriftsartikel (refereegranskat)abstract
    • Endoscopy with histopathological assessment is an established practice to confirm gastrointestinal graft-versus-host disease (GI-GVHD). However, the clinical relevance of this approach in children is incompletely evaluated. In a retrospective cohort study, we investigated the frequency of treatment changes in response to histopathological findings in all children (<18 years) in Sweden who underwent endoscopy for suspected GI-GVHD (2000-2013) after receiving hematopoietic stem cell transplantation. Sixty-eight children with ninety-one endoscopic occasions were enrolled. At the time of endoscopy, anti-GI-GVHD treatment was ongoing in 71% (65/91). In 18% (12/65) with ongoing treatment, no histopathological evidence of GI-GVHD or another cause to justify anti-GI-GVHD treatment was found. In 48% (44/91), endoscopy with histopathological assessment led to changes in the treatment regimen. Re-endoscopy was more frequent among those with treatment changes, versus unchanged treatment, 39% (17/44) and 13% (6/47), respectively (P = .007). Histopathological findings generating treatment changes were as follows: GI-GVHD in 68% (30/44), normal histology in 25% (11/44), and an alternative diagnosis in 7% (3/44). In conclusion, this study supports that endoscopy with histopathological assessment should be considered in all children with suspected GI-GVHD.
  • Mårtensson, Thomas, et al. (författare)
  • Diagnostic disagreement between clinical standard histopathological- and retrospective assessment of histopathology-based gastrointestinal graft-versus-host disease in children
  • 2020
  • Ingår i: Pediatric Transplantation. - : WILEY. - 1397-3142 .- 1399-3046. ; 24:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: No previous paediatric study has evaluated the frequency of diagnostic disagreement between clinical standard histopathological assessment (CSHA) and retrospective, independent, histopathological assessment (RIHA) of gastrointestinal Graft-Versus-Host Disease (GI-GVHD).Methods: In a retrospective cohort study, based on gastrointestinal biopsies collected from allogeneic HSCT-treated children (<18 years) with symptom-based GI-GVHD, we evaluated; disagreement of histopathology-based GI-GVHD diagnosis in CSHA vs RIHA, and potential clinical consequences of differences between the assessments. The CSHA-based diagnoses were retrieved from histopathology reports. The RIHA was performed by one pathologist, blinded to the CSHA outcomes and based on the minimal criteria for histopathology-based GI-GVHD diagnosis by theNIH 2014.Results: Seventy children with 92 endoscopic occasions (including 22 re-endoscopies) were enrolled. GI-GVHD was observed in 73% (67/92) of the endoscopies in the RIHA and in 54% (50/92) in the CSHA (P = .014). The RIHA confirmed 94% (47/50) with GI-GVHD and 52% (22/42) with non-GI-GVHD diagnoses, established in the CSHA. Disagreement, that is endoscopic occasions with GI-GVHD solely detected in RIHA or detection of GI-GVHD in CSHA but not in RIHA, was observed in 20/42 (48%) and 3/50 (6%), respectively (McNemar's test, P = .0008). The risk of a subsequent re-endoscopy was higher in endoscopic occasions with GI-GVHD detected in RIHA but not in CSHA vs if non-GI-GVHD were detected in both readings (P = .005).Conclusion: Our results suggest that in children with symptom-based GI-GVHD without histopathological confirmation in CSHA, a second,NIH 2014based histopathological assessment should be considered before performing a re-endoscopy.
  • Carlsson, Georg, et al. (författare)
  • Perennial species mixtures for multifunctional production of biomass on marginal land
  • Ingår i: GCB Bioenergy. - : John Wiley and Sons. - 1757-1693 .- 1757-1707. ; 9:1, s. 191-201
  • Tidskriftsartikel (refereegranskat)abstract
    • Multifunctional agriculture provides noncommodity functions and services along with food, feed and bioenergy feedstocks, for example by preserving or promoting biodiversity, improving soil fertility, mitigating climate change and environmental degradation, and contributing to the socio-economic viability of rural areas. Producing biomass for bioenergy from low-input perennial species mixtures on marginal land has the potential to support biodiversity and soil carbon sequestration in synergy with greenhouse gas mitigation. We compared biomass production in species-rich mixtures of perennial grasses, legumes and forbs with pure-stand grasses and relatively species-poor mixtures under different nitrogen fertilization regimes. Field experiments were performed on different types of marginal land, that is agricultural field margins and land with poor soil fertility, at four sites in southernmost and western Sweden. Biomass production was measured for three years in perennial grasses grown as pure stands, in legume-grass mixtures, and legume-grass-forb mixtures across a species richness gradient. In unfertilized species-rich mixtures, average biomass yields per experimental site and year were in the range from 3 to 9 metric ton DM ha−1 yr−1. While the most productive pure-stand grasses fertilized with 60–120 kg N ha−1 yr−1 often produced higher biomass yields than unfertilized mixtures, these differences were generally smaller than the variations between years and sites. Calculations of climate impact using the harvested biomass for conversion to biogas as vehicle fuel showed that the average greenhouse gas emissions per energy unit were about 50% lower in unfertilized systems than in treatments fertilized with 100–120 kg N ha−1 yr−1. Our findings thereby show that unfertilized species-rich perennial plant mixtures on marginal land provide resource-efficient biomass production and contribute to the mitigation of climate change. Perennial species mixtures managed with low inputs thus promote synergies between productivity and biodiversity in the perspective of climate-smart and multifunctional biomass production.
  • Dahlström, Mia, et al. (författare)
  • Impact of polymer surface affinity of novel antifouling agents
  • 2004
  • Ingår i: Biotechnology and Bioengineering. - : John Wiley & Sons. - 0006-3592 .- 1097-0290. ; 86:1, s. 1-8
  • Tidskriftsartikel (refereegranskat)abstract
    • In a previous study we found two agents, the 2-agonist medetomidine ((±)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole) and the 2-agonist clonidine (2-(2,6-dichloroanilino)-2-imidazoline), that specifically and efficiently impede settlement of the barnacle Balanus improvisus, one of the most serious biofouling organisms in Swedish waters. Medetomidine, but not clonidine, is known to adsorb to solid polystyrene (PS) surfaces in the presence of salt, a feature that is of particular interest in attempts to develop an efficient antifouling surface. We show that medetomidine, but not clonidine, has a significant ability to adsorb to untreated (hydrophobic) PS in two different incubation media: filtered seawater (FSW) and deionized water (mQ). At negatively charged (hydrophilic) PS, medetomidine displays a strong interaction with the surface in both incubation media. At the hydrophilic PS, clonidine also displays a significant interaction with the surface when incubated in mQ and a weaker, but not significant, interaction when incubated in FSW. By studying the effects of time, incubation media, and pH on the adsorption of medetomidine and clonidine, we suggest that medetomidine is associated to hydrophobic PS by means of hydrophobic interactions, while the adsorption of medetomidine and clonidine to hydrophilic PS contains elements of electrostatic interaction. Using time-of-flight secondary ion mass spectroscopy (TOF-SIMS) we detected only weak signals from medetomidine on the hydrophobic PS surfaces, while strong medetomidine signals were observed on hydrophilic PS. This suggests that the adsorbed medetomidine, to a greater extent, desorbed from the hydrophobic rather than from the hydrophilic PS surfaces during exposure to vacuum. The strong surface affinity of medetomidine on both types of surfaces and the preserved antifouling activity are valuable features in designing a marine coating.
  • Dencker, Kerstin, et al. (författare)
  • Proactive assembly systems-realising the potential of human collaboration with automation
  • 2009
  • Ingår i: Annual Reviews in Control. - 1367-5788 .- 1872-9088. ; 33:2, s. 230-237
  • Tidskriftsartikel (refereegranskat)abstract
    • Manufacturing competitiveness frequently relies on company ability to rapidly reconfigure theirassembly systems. This paper introduces assembly system proactivity, a concept based on interrelated levels of automation, human competence, and information handling. Increased and structured human involvement contributes to increased system ability to proactively address predicted and unpredictedevents. Correct involvement of human operators will utilize the combined potential of human and technical capabilities, providing cost-efficient assembly system solutions. The ProAct project is developing proactive assembly system models and evaluates proactive, feature-based solutions. Focus is on realising the potential of cost-efficient and semi-automated systems with relevant human involvement, i.e. highly skilled operators who add flexibility and functionality.
  • Dick Thelander, Kimberly, et al. (författare)
  • Growth of GaP nanotree structures by sequential seeding of 1D nanowires
  • 2004
  • Ingår i: Journal of Crystal Growth. - : Elsevier. - 0022-0248. ; 272:1-4, s. 131-137
  • Tidskriftsartikel (refereegranskat)abstract
    • Complex nanostructures are becoming increasingly important for the development of nanoscale devices and functional nanomaterials. Precise control of size and morphology of these structures is critical to their fabrication and exploitation. We have developed a method for stepwise growth of tree-like nanostructures via the vapour liquid-solid (VLS) growth mode, demonstrated for III-V semiconductor materials. This method uses the initial seeding of nanowires by catalytic aerosol nanoparticles to form the trunk, followed by sequential seeding of branching structures. Here we present a detailed study of the growth of these complex structures using Gap. Diameter of each level of nanowires is directly determined by seed particle diameters, and number of branches is determined by seed particle density. Growth rate is shown to increase with temperature to a maximum corresponding to the temperature of complete decomposition of the Group-III precursor material, and subsequently decrease due to competition with bulk growth. Growth rate also depends on flow of the Group-III precursor, but not on the Group-V precursor. Finally, there is a relationship between the number of branches and their growth rate, suggesting that material diffusion plays a role in nanowire branch growth. (C) 2004 Elsevier B.V. All rights reserved.
  • Mårtensson, Annica, et al. (författare)
  • PEBP2 and c-myb sites crucial for lambda5 core enhancer activity in pre-B cells.
  • 2001
  • Ingår i: European Journal of Immunology. - 0014-2980 .- 1521-4141. ; 31:11, s. 3165-3174
  • Tidskriftsartikel (refereegranskat)abstract
    • The lambda5 gene is expressed exclusively in precursor (pre-) B cells where its gene product, as part of the pre-B cell receptor, is crucial for the proliferation of these cells. Several DNA regions regulate the activity and expression pattern of the lambda5 gene. Amongst these is an enhancer, B(lambda5), located 5' of the gene. Here we analyze the lambda5 enhancer core, b(lambda5), which in earlier experiments was demonstrated to retain 50% of the enhancer activity, and show that this activity is restricted to pre-B cells. We identify a DNA element within b(lambda5), PEBP2(lambda5), which is essential for enhancer activity: mutation within this site dramatically reduces core enhancer activity in pre-B cells. The PEBP2(lambda5) site binds bacterially produced polyoma enhancer binding proteins (PEBP) (Runx/AML/CBFA). Furthermore, PEBP2 proteins present in nuclear extracts from murine pre-B cells bind to the PEBP2(lambda5) element. PEBP2 proteins in mature B cells also bind to the PEBP2(lambda5 )element, implying that if PEBP2 proteins are responsible for the stage-specific expression, they have to be non-activating or inhibiting in mature B cells. We also demonstrate that a described partner of PEBP2, c-myb, binds to a sequence termed myb(lambda5) located just upstream of the PEBP2(lambda5) site in the core enhancer. The myb(lambda5) element is also crucial for enhancer activity, since mutating the myb site reduces core enhancer activity to the same extent as mutating the PEBP2 site. Earlier reports have shown that c-myb is expressed at high levels in pre-B cell lines whereas its expression is down-regulated in more mature B cell lines. Thus, c-myb may be involved in determining the stage-specific expression of the lambda5 gene.
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