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A retrospective cas...
A retrospective case-control study of gastrostomy use in children undergoing hematopoietic cell transplantation
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- Mellgren, Karin, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens Univ Hosp, Dept Pediat Oncol, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Gothenburg, Sweden.
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- Nicolajsen, T. (författare)
- NU Sjukvarden, Dept Paediat, Trollhättan, Sweden.
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- Christoforaki, Tania Panagiota (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning
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- Juan, S. M. (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Paediat, Stockholm, Sweden.
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- Mårtensson, Thomas (författare)
- Uppsala universitet,Internationell barnhälsa och nutrition
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- Toporski, J. (författare)
- Skane Univ Hosp, Dept Pediat, Lund, Sweden.
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- Casswall, T. H. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Paediat, Stockholm, Sweden.
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- Gustafsson, B. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Pediatric Transplantation. - : John Wiley & Sons. - 1397-3142 .- 1399-3046. ; 27:4
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundMaintaining a good nutritional status during the hematopoietic cell transplantation (HCT) procedure is challenging in the pediatric population. MethodsIn a multicentric retrospective study, we compared the outcome of nutritional status and HCT-related parameters in 227 pediatric patients during and after HCT between 2005 and 2015. 112 patients received a gastrostomy before the start of HCT (GS group), and 115 did not receive a gastrostomy (NGS). Data collection was performed at HCT, 3, 6, and 12 months post-HCT. ResultsAt time point of HCT the Standard Deviation Score (SDS) of weight was 0.17 in the NGS group, and 0.71 in the GS group (p = .01) Patients in the NGS group lost more weight during the first 3 months after HCT than patients in the GS group. At 12 months, patients in the NGS remained at a lower weight, while patients in the GS group slightly increased their weight.There were no differences between the groups in the incidence of acute graft-versus-host-disease (GvHD), overall survival, and non-relapse mortality. However, the number of febrile episodes requiring intravenous treatment with antibiotics, was higher in the GS group as compared to the NGS group, during the first 3 months post-HCT (p < .001). ConclusionsOur results indicate that gastrostomy can be utilized in children undergoing HCT without any negative effects on mortality. Therefore, the use of a gastrostomy appears to be a safe option to maintain a good nutritional status during the HCT procedure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Hematopoietic stem cell transplantation
- gastrostomy
- nutritional
- support
- pediatric patients
- pediatric-patients
- cancer
- nutrition
- Pediatrics
- Transplantation
- Hematopoietic stem cell transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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