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Dense genotyping of...
Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.
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- Westerlind, Helga (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Mellander, Marie-Rose (författare)
- Karolinska Institute,Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Bresso, Francesca (författare)
- Karolinska Institute,Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Munch, Andreas (författare)
- Linköping University,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Hälsouniversitetet,Dept Clin & Expt Med, Fac Hlth Sci, Linköpings Univ, Linköping, Sweden
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- Bonfiglio, Ferdinando (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Assadi, Ghazaleh (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Rafter, Joseph (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Hübenthal, Matthias (författare)
- Christian-Albrechts-University of Kiel, Kiel, Germany,Inst Clin Mol Biol, Christian Albrechts Univ Kiel, Kiel, Germany
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- Lieb, Wolfgang (författare)
- Christian-Albrechts-University of Kiel, Kiel, Germany,Inst Epidemiol, Christian Albrechts Univ Kiel, Kiel, Germany; Biobank POPGEN, Christian Albrechts Univ Kiel, Kiel, Germany
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- Källberg, Henrik (författare)
- Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Brynedal, Boel (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Padyukov, Leonid (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Halfvarson, Jonas, 1970- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden,Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Törkvist, Leif (författare)
- Karolinska Institutet,Karolinska University Hospital, Stockholm, Sweden
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- Bjork, Jan (författare)
- Karolinska University Hospital, Stockholm, Sweden,Gastroctr, Karolinska Univ Hosp, Stockholm, Sweden
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- Andreasson, Anna (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Agreus, Lars (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Almer, Sven (författare)
- Karolinska Institutet,Karolinska Institute,arolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Miehlke, Stephan (författare)
- Internal Medicine Center Eppendorf, Hamburg, Germany,Ctr Digest Dis, Internal Med Ctr Eppendorf, Hamburg, Germany,University Medical Center Hamburg-Eppendorf
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- Madisch, Ahmed (författare)
- Siloah Hospital, Hannover, Germany,Clin Gastroenterol Endoscopy & Intervent Diabetol, Siloah Hosp, Hannover, Germany
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- Ohlsson, Bodil (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital, Lund University, Lund, Sweden
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- Löfberg, Robert (författare)
- Karolinska Institute,Karolinska Institutet, Stockholm, Sweden Sophiahemmet Hospital, Stockholm, Sweden
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- Hultcrantz, Rolf (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institutet, Stockholm, Sweden
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- Franke, Andre (författare)
- Christian-Albrechts-University of Kiel, Kiel, Germany,Inst Clin Mol Biol, Christian Albrechts Univ Kiel, Kiel, Germany
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- D'Amato, Mauro (författare)
- Karolinska Institute,Karolinska Institutet, Stockholm, Sweden BioCruces Health Research Institute and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
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(creator_code:org_t)
- 2015-11-02
- 2017
- Engelska.
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Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 66:3, s. 421-428
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated. We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role.DESIGN: Three independent cohorts of histologically confirmed CC cases (N=314) and controls (N=4299) from Sweden and Germany were included in a 2-step association analysis. Immunochip and targeted single nucleotide polymorphism (SNP) genotype data were produced, respectively, for discovery and replication purposes. Classical human leucocyte antigen (HLA) variants at 2-digit and 4-digit resolution were obtained via imputation from single marker genotypes. SNPs and HLA variants passing quality control filters were tested for association with CC with logistic regression adjusting for age, sex and country of origin.RESULTS: Forty-two markers gave rise to genome-wide significant association signals, all contained within the HLA region on chromosome 6 (best p=4.2×10(-10) for SNP rs4143332). Among the HLA variants, most pronounced risk effects were observed for 8.1 haplotype alleles including DQ2.5, which was targeted and confirmed in the replication data set (p=2.3×10(-11); OR=2.06; 95% CI (1.67 to 2.55) in the combined analysis).CONCLUSIONS: HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- COLLAGENOUS COLITIS; GENETICS; HLA GENES
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- ref (ämneskategori)
- art (ämneskategori)
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Westerlind, Helg ...
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Mellander, Marie ...
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Bresso, Francesc ...
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Munch, Andreas
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Bonfiglio, Ferdi ...
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Assadi, Ghazaleh
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visa fler...
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Rafter, Joseph
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Hübenthal, Matth ...
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Lieb, Wolfgang
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Källberg, Henrik
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Brynedal, Boel
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Padyukov, Leonid
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Halfvarson, Jona ...
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Törkvist, Leif
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Bjork, Jan
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Andreasson, Anna
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Agreus, Lars
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Almer, Sven
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Miehlke, Stephan
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Madisch, Ahmed
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Ohlsson, Bodil
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Löfberg, Robert
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Hultcrantz, Rolf
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Franke, Andre
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D'Amato, Mauro
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Linköpings universitet
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Karolinska Institutet