Sökning: WFRF:(Magdalinou N. K.)
> (2018)
> Poole T. >
CSF neurogranin or ...
CSF neurogranin or tau distinguish typical and atypical Alzheimer disease
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Wellington, H. (författare)
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Paterson, R. W. (författare)
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Suarez-Gonzalez, A. (författare)
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visa fler...
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Poole, T. (författare)
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Frost, C. (författare)
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Sjobom, U. (författare)
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Slattery, C. F. (författare)
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Magdalinou, N. K. (författare)
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Lehmann, M. (författare)
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- Portelius, Erik, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fox, N. C. (författare)
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, J. M. (författare)
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(creator_code:org_t)
- 2018-01-11
- 2018
- Engelska.
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Ingår i: Annals of Clinical and Translational Neurology. - : Wiley. - 2328-9503. ; 5:2, s. 162-171
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https://gup.ub.gu.se... (primary) (free)
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To assess whether high levels of cerebrospinal fluid neurogranin are found in atypical as well as typical Alzheimer's disease. Methods: Immunoassays were used to measure cerebrospinal fluid neurogranin in 114 participants including healthy controls (n=27), biomarker-proven amnestic Alzheimer's disease (n=68), and the atypical visual variant of Alzheimer's (n=19) according to international criteria. CSF total-tau, A beta 42, and neurofilament light concentrations were investigated using commercially available assays. All affected individuals had T1-weighted volumetric MR images available for analysis of whole and regional brain volumes. Associations between neurogranin, brain volumes, total-tau, A beta 42, and neurofilament light were assessed. Results: Median cerebrospinal fluid neurogranin concentrations were higher in typical and atypical Alzheimer's compared to controls (P<0.001 and P=0.005). Both neurogranin and total-tau concentrations, but not neurofilament light and A beta 42, were higher in typical Alzheimer's compared to atypical patients (P=0.004 and P=0.03). There were significant differences in the left hippocampus and right and left superior parietal lobules in atypical patients, which were larger (P=0.03) and smaller (P=0.001 and P<0.001), respectively, compared to typical patients. We found no evidence of associations between neurogranin and brain volumes but a strong association with total-tau (P<0.001) and a weaker association with neurofilament light (P=0.005). Interpretation: These results show significant differences in neurogranin and total-tau between typical and atypical patients, which may relate to factors other than disease topography. The differential relationships between neurogranin, total-tau and neurofilament light in the Alzheimer's variants, provide evidence for mechanistically distinct and coupled markers of neurodegeneration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- posterior cortical atrophy
- cerebrospinal-fluid biomarkers
- neurofilament light
- cognitive impairment
- neuronal-activity
- synapse
- loss
- in-vivo
- dementia
- association
- sclerosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Wellington, H.
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Paterson, R. W.
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Suarez-Gonzalez, ...
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Poole, T.
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Frost, C.
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Sjobom, U.
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visa fler...
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Slattery, C. F.
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Magdalinou, N. K ...
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Lehmann, M.
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Portelius, Erik, ...
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Fox, N. C.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Schott, J. M.
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Göteborgs universitet