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Träfflista för sökning "WFRF:(Magnusson Maria 1960 ) "

Sökning: WFRF:(Magnusson Maria 1960 )

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1.
  • Magnusson, Maria, 1960-, et al. (författare)
  • Att tillägna sig skriftspråkliga verktyg genom att leka affär
  • 2019
  • Ingår i: Forskning om undervisning och lärande. - Lärarstiftelsen. - 2000-9674. ; 7:1, s. 23-43
  • Tidskriftsartikel (refereegranskat)abstract
    • Artikeln fokuserar ett tema över tid i form av affärslek där förskollärare såväl som barn har olika roller, både i tillblivelsen och i utvecklingen. Studien ingår i ett större projekt om lekbaserad undervisning i förskolan. Empiri för den aktuella studien utgörs av videoobservationer av återkommande affärslek i en förskola. Syftet var att studera hur skriftspråkliga verktyg kommer i spel mellan barn och mellan förskollärare och barn för att stödja barns symbolförståelse. Resultaten visar: (i) vilka skriftspråkliga verktyg (begrepp, distinktioner) som förs in och aktualiseras i leken och (ii) hur dessa approprieras och ges betydelse för lekens fortsättning. Den aspekt av skrift som blir särskilt tydlig är symbolers kommunikativa funktioner. För lekens fortskridande blir det skriftspråkliga innehållet betydelsefullt liksom hur förskolläraren i lek hanterar skriftspråkliga verktyg i respons på barns agerande. Studien ger, genom sin empirinära analys, exempel på undervisning på basis av lek i förskolan.
2.
  • Andersson, Kerstin, et al. (författare)
  • Yersinia pseudotuberculosis-induced calcium signaling in neutrophils is blocked by the virulence effector YopH
  • 1999
  • Ingår i: Infection and Immunity. - 0019-9567. ; 67:5, s. 2567-2574
  • Tidskriftsartikel (refereegranskat)abstract
    • Pathogenic species of the genus Yersinia evade the bactericidal functions of phagocytes. This evasion is mediated through their virulence effectors, Yops, which act within target cells. In this study we investigated the effect of Yersinia pseudotuberculosis on Ca 2+ signaling in polymorphonuclear neutrophils. The intracellular free calcium concentration in single adherent human neutrophils was monitored during bacterial infection and, in parallel, the encounter between the bacteria and cells was observed. When a plasmid-cured strain was used for infection, adherence of a single bacterium to the cellular surface induced a β 1 integrin-dependent transient increase in the intracellular concentration of free calcium. This was, however, not seen with Yop-expressing wild-type bacteria, which adhered to the cell surface without generating any Ca 2+ signal. Importantly, the overall Ca 2+ homeostasis was not affected by the wild-type strain; the Ca 2+ signal mediated by the G-protein-coupled formyl-methionyl-leucyl- phenylalanine receptor was still functioning. Hence, the blocking effect was restricted to certain receptors and their signaling pathways. The use of different Yop mutant strains revealed that the protein tyrosine phosphatase YopH was responsible for the inhibition. This virulence determinant has previously been implicated in very rapid Yersinia-mediated effects on target cells as the key effector in the blockage of phagocytic uptake. The present finding, that Y. pseudotuberculosis, via YopH, specifically inhibits a self- induced immediate-early Ca 2+ signal in neutrophils, offers more-detailed information concerning the effectiveness of this virulence effector and implies an effect on Ca 2+-dependent, downstream signals.
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3.
  • Att möta barns sociala språkmiljö i förskolan : flerdimensionella perspektiv
  • 2019
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt)abstract
    • Barn kommer till förskolan med varierande erfarenheter av språk. Förskolan har därför en betydande roll i barns tidiga språk-, läs och skrivutveckling, inte minst i ett likvärdighetsperspektiv. Förskolan behöver organiseras så att alla barn får tillgång till stimulerande språk,- skriv- och läsfrämjande lärandemiljöer. Boken handlar om hur förskolan kan skapa sådana sociala språkmiljöer.Boken bidrar med tydliga exempel från förskollärares vardagliga arbete. Den är uppbyggd utifrån tre teman med inriktning mot språk, och bidrar med en modell som visar de lärandestrategier som kännetecknar en social språkmiljö: omsorgsstrategier, kommunikativa strategier och lekstrategier. Författarna kommer både från praktiken i förskolorna och från forskarkåren och arbetar aktivt med frågor som handlar om barns språkutveckling.Boken riktar sig till förskollärarstuderande, lärarutbildare, förskollärare och andra verksamma i förskolan samt forskare inom pedagogik och didaktik. Den lämpar sig mycket väl för kollegialt lärande i förskolan och för diskussioner i arbetslag.
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4.
  • Bokarewa, Maria, et al. (författare)
  • Arthritogenic dsRNA is present in synovial fluid from rheumatoid arthritis patients with an erosive disease course.
  • 2008
  • Ingår i: European journal of immunology. - 0014-2980. ; 38:11, s. 3237-44
  • Tidskriftsartikel (refereegranskat)abstract
    • Viruses may be part of the pathogenesis of rheumatoid arthritis (RA). Double stranded RNA (dsRNA) is a prototypic viral conformation of nucleic acid that is highly arthritogenic in mice. Therefore, we developed an ELISA to detect dsRNA in sera and synovial fluids (SF) in RA patients and in osteoarthritic controls. The developed ELISA recognizes picogram levels of viral or synthetic dsRNA but shows no reactivity against DNA, synthetic ssRNA, or total RNA prepared from mammalian cells. Before analysis by ELISA, each sample was subjected to RNA precipitation. The RA patients had significantly higher levels of dsRNA than the osteoarthritis patients in SF and in sera. In 7 of 17 RA patients, EBV was present in SF and in all but one of these this was accompanied by the presence of dsRNA. No parvovirus, cytomegalovirus, or polyomavirus was detected. The anti-viral cytokine IFN-alpha was detected in SF in 10 of 21 RA patients, but in none of the osteoarthritis patients. Notably, RA patients with erosive disease course had significantly higher levels of dsRNA in SF than non-erosive patients, but no correlation between dsRNA levels and the presence of RF or levels of C-reactive protein, IL-6, or IFN-alpha was observed.
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5.
  • Hofslundsengen, Hilde, et al. (författare)
  • Preschool literacy environment in the Nordic countries
  • 2016
  • Ingår i: Abstract book. 26th EECERA Annual Conference, Happiness, Relationships, Emotion & Deep Level Learning, Dublin, 31st-3rd September, 2016.
  • Konferensbidrag (refereegranskat)abstract
    • The aim of the current study was to detect similarities and differences in the preschool literacy environment in the Nordic countries, with a special focus on what the environment offered to multilingual children who do not speak the language. Some minor studies (Bøyum, Hofslundsengen, Haukedal & Pedersen, 2016; Dahlgren, Gustafsson, Mellgren & Olsson 2013; Mellgren, Skriver Jensen & Hansen 2010; Mårdsjö Olsson & Löfström 2008; Simonsson, 2004; Svensson 2005, 2007, 2009; Öman 1986) has indicated less literacy activities in some preschools. This study expands on the earlier work of literacy environment. The theoretical base is socio-cultural as artefacts are looked upon as vehicles of the culture in which children live. We present a survey of the literacy environment in Finland, Norway and Sweden. The data consisted of mapping in 20 preschool classrooms in each of the three countries including number of books, children's access to books, reading and writing activities and digital tools. The participating preschools gave informed consents to data collection. This study contributes to knowledge about what experiences of literacy children at the ages of 0 to 6 years get during their stay in preschool, if these experiences differ among the Nordic countries and if so, how and in what way they differ. The finding from the study adds to the limited knowledge about literacy learning in the Nordic preschool system, 171 and implies the importance of preschools literacy environment for children's development of emergent literacy skills.
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6.
  • Hofslundsengen, Hilde, et al. (författare)
  • The literacy environment of preschool classrooms in three Nordic countries : challenges in a multilingual and digital society
  • 2018
  • Ingår i: Early Child Development and Care. - Taylor & Francis. - 0300-4430. ; s. 1-14
  • Tidskriftsartikel (refereegranskat)abstract
    • This study investigates the physical literacy environment of preschools in three Nordic countries. The environments were assessed using an observation protocol in a total of 131 classrooms with children aged between one and seven in Sweden, Norway and Finland. The results showed that children’s books were common and accessible in all three countries. Half of the preschools had a writing centre, and digital devices were available in less than half of them. Multilingual children were present in 82% of the classrooms, but texts and books in the multilingual children’s first languages were rare. Taken together, the results suggest that children’s books were the main gateway to literacy in these preschools, while artefacts supporting writing skills and digital literacy were less common. The findings indicate that the physical environment in these preschools did not reflect the ongoing societal changes towards increased multimodal literacy.
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9.
  • Magnusson, Maria, 1960-, et al. (författare)
  • Early literacy in a Nordic perspective : Discernment and patterns in degree project for preschool teachers
  • 2016
  • Ingår i: Abstract book. 26th EECERA Annual Conference, Happiness, Relationships, Emotion & Deep Level Learning, Dublin, 31st-3rd September, 2016.
  • Konferensbidrag (refereegranskat)abstract
    • The aim of the pilot study is to generate knowledge about how to support preschool teacher students' abilities to communicate the results of the Degree Project related to previous research and teaching as profession. More specifically, we aim to investigate into what aspects are discerned and noticeable and come into foreground. Relation to previous work on the learning process (Marton, 2015) and teachers-students' global competencies (Tarrant, Rubin & Stoner, 2013). The theoretical base of the study is variation theory (Marton, 2015) and its theoretical concepts of variation and discernment. Video-observation is used for capturing verbal expression. The participating students gave informed consents to the video recording and how it will be used. Recordings are stored in accordance with rules and guidelines of Swedish Research Council (Vetenskapsrådet, 2011). The global/Nordic classroom seems to help students catch sight of the similarities and differences in a metaperspective, in relation to the Degree project, but also to the profession. Preliminary results show that student seem to make independent judgments and commute between the scientific and professional. Findings support further tests of the possibility to let students write their Degree project in a specific field such as Early Literacy and implement ''webinars'' in the global/Nordic classroom.
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