SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Mahteme Haile) srt2:(2005-2009);lar1:(ki)"

Search: WFRF:(Mahteme Haile) > (2005-2009) > Karolinska Institutet

  • Result 1-2 of 2
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Mahteme, Haile, et al. (author)
  • Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis
  • 2008
  • In: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 34:5, s. 547-552
  • Journal article (peer-reviewed)abstract
    • AIMS: To investigate if the pattern of cytotoxic drug sensitivity in vitro in patient samples of peritoneal carcinomatosis (PC) is supportive to the current standardized approach for drug selection for perioperative intraperitoneal chemotherapy (IPC). METHODS: The cytotoxic effect of cisplatin, oxaliplatin, irinotecan, 5-fluorouracil, mitomycin-C, doxorubicin and melphalan was investigated in vitro on tumour cells from 223 patient tumour samples of different PC origins. RESULTS: Considerable differences in cytotoxic drug sensitivity between tumour types of the PC entity and within each tumour type were observed. Cisplatin showed high cross-resistance with oxaliplatin but low cross-resistance with doxorubicin and irinotecan. No cross-resistance was found between irinotecan and doxorubicin. The dose-response relationships for melphalan and irinotecan in individual samples showed great variability. CONCLUSIONS: The activity in vitro of cytotoxic drugs commonly used in IPC for PC is very heterogeneous. Efforts for individualizing drug selection for PC patients undergoing IPC seem justified.
  •  
2.
  • Mahteme, Haile, et al. (author)
  • Systemic exposure of the parent drug oxaliplatin during hyperthermic intraperitoneal perfusion
  • 2008
  • In: European Journal of Clinical Pharmacology. - : Springer Science and Business Media LLC. - 0031-6970 .- 1432-1041. ; 64:9, s. 907-911
  • Journal article (peer-reviewed)abstract
    • Objective To evaluate the perfusate and systemic kinetics of oxaliplatin during hyperthermic intraperitoneal chemotherapy (HIPEC) using a selective analytical technique. Methods HIPEC was carried out in eight patients by the open abdomen coliseum technique for 30 min at 41.5-43 degrees C with an average of 427 mg/m(2) of oxaliplatin in 5% dextrose solution. Blood and perfusate samples were collected during the perfusion. Additional blood samples were taken up to 2 h after the end of perfusion. The analysis was performed by liquid chromatography and post-column derivatization with N,N-diethyldithiocarbamate using microwave heating. Results The mean elimination half-life of oxaliplatin in the perfusate was 29.5 min (range 21.1-41.2 min) and in the peripheral circulation 24.7 min (range 21.7-27.7 min). The ratio of the areas under the time concentration curve in perfusate and blood was 12.8 +/- 2.9. Conclusion The systemic exposure of oxaliplatin measured after HIPEC using a selective analytical technique is considerably lower than previously reported results obtained by atomic absorption spectroscopy.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Glimelius, Bengt (2)
Påhlman, Lars (2)
Mahteme, Haile (2)
Larsson, Rolf (1)
Nygren, Peter (1)
von Heideman, Anne (1)
show more...
Graf, Wilhelm (1)
Grundmark, Birgitta (1)
Tholander, B (1)
Ehrsson, Hans (1)
Wallin, I (1)
show less...
University
Uppsala University (2)
Karolinska Institutet  (2)Undo refine
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2008 (2)

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view