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Novel activity of a...
Novel activity of acriflavine against colorectal cancer tumor cells
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- Hassan, Saadia (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Laryea, Daniel (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Mahteme, Haile (author)
- Uppsala universitet,Kolorektalkirurgi
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- Felth, Jenny (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Fryknäs, Mårten (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Fayad, Walid (author)
- Oncology and pathology - Karolinska Institutet
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- Linder, Stig (author)
- Karolinska Institutet
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- Rickardson, Linda (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Gullbo, Joachim (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Graf, Wilhelm (author)
- Uppsala universitet,Kolorektalkirurgi
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- Pålman, Lars (author)
- Uppsala universitet,Kolorektalkirurgi
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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- Larsson, Rolf (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Nygren, Peter (author)
- Uppsala universitet,Enheten för onkologi,Nygren
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(creator_code:org_t)
- 2011-10-12
- 2011
- English.
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In: Cancer Science. - : Wiley. - 1347-9032 .- 1349-7006. ; 102:12, s. 2206-2213
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Abstract
Subject headings
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- A high-throughput screen of the cytotoxic activity of 2000 molecules from a commercial library in three human colon cancer cell lines and two normal cell types identified the acridine acriflavin to be a colorectal cancer (CRC) active drug. Acriflavine was active in cell spheroids, indicating good drug penetration and activity against hypoxic cells. In a validation step based on primary cultures of patient tumor cells, acriflavine was found to be more active against CRC than ovarian cancer and chronic lymphocytic leukemia. This contrasted to the activity pattern of the CRC active standard drugs 5-fluorouracil, irinotecan and oxaliplatin. Mechanistic studies indicated acriflavine to be a dual topoisomerase I and II inhibitor. In conclusion, the strategy used seems promising for identification of new diagnosis-specific cancer drugs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Acriflavine
- colorectal cancer
- topoisomerase
- drug screening
- Clinical pharmacology
- Klinisk farmakologi
- Medicin
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Hassan, Saadia
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Laryea, Daniel
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Mahteme, Haile
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Felth, Jenny
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Fryknäs, Mårten
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Fayad, Walid
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Linder, Stig
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Rickardson, Lind ...
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Gullbo, Joachim
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Graf, Wilhelm
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Pålman, Lars
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Glimelius, Bengt
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Larsson, Rolf
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Nygren, Peter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Cancer Science
- By the university
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Uppsala University
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Karolinska Institutet