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- Aaltonen, T., et al.
(författare)
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Combination of Tevatron Searches for the Standard Model Higgs Boson in the W+W- Decay Mode
- 2010
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061802-
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Tidskriftsartikel (refereegranskat)abstract
- We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L.
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- Battaleb-Looie, S., et al.
(författare)
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Fluoride in groundwater, dates and wheat : Estimated exposure dose in the population of Bushehr, Iran
- 2013
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Ingår i: Journal of Food Composition and Analysis. - : Elsevier BV. - 0889-1575 .- 1096-0481. ; 29:2, s. 94-99
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Tidskriftsartikel (refereegranskat)abstract
- The goal of this study was to estimate the daily fluoride intake for residents of Bushehr province in southern Iran by determining their exposure to fluoride through consumption of drinking water, dates and wheat. The fluoride concentration of drinking water in this region varies between 0.5 and 3.0mg/L, with an average of 1.6mg/L; and 44.4% of the drinking water exceed the guideline value of 1.5mg/L recommended by WHO. The average fluoride content of dates is 10.0mg/kg; whereas wheat roots and shoots contain an average of 30.0 and 19.0mgF-/kg, respectively. The estimated intake from drinking water is 0.12mg/kg/d for children (20kg body weight) and 0.05mg/kg/d for adults (70kg body weight). The total estimated fluoride intake (from drinking water and dates) for children is 0.17mg/kg/d. Thus, dates contribute an average 30% to the daily fluoride intake in the population. The maximum estimated fluoride intake (from dates and drinking water) for children and adults are 3.4 and 1.6 times higher, respectively, than the minimum risk level of 0.05mg/kg/d calculated by Agency for Toxic Substances and Disease Registry.
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| 10. |
- Clabbers, Max T. B., et al.
(författare)
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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystalline higher-order assemblies of the MyD88 TIR domain (MyD88TIR). These crystals are too small for conventional X-ray crystallography, but are ideally suited to structure determination by microcrystal electron diffraction (MicroED) and serial femtosecond crystallography (SFX). Here, we present MicroED and SFX structures of the MyD88TIR assembly, which reveal a two-stranded higher-order assembly arrangement of TIR domains analogous to that seen previously for MALTIR. We demonstrate via mutagenesis that the MyD88TIR assembly interfaces are critical for TLR4 signaling in vivo, and we show that MAL promotes unidirectional assembly of MyD88TIR. Collectively, our studies provide structural and mechanistic insight into TLR signal transduction and allow a direct comparison of the MicroED and SFX techniques.
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